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Gut Pathogens
Published in: Gut Pathogens 1/2018

Open Access 01-12-2018 | Review

Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities

Authors: Dachao Liang, Ross Ka-Kit Leung, Wenda Guan, William W. Au

Published in: Gut Pathogens | Issue 1/2018

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Abstract

The commensal, symbiotic, and pathogenic microbial community which resides inside our body and on our skin (the human microbiome) can perturb host energy metabolism and immunity, and thus significantly influence development of a variety of human diseases. Therefore, the field has attracted unprecedented attention in the last decade. Although a large amount of data has been generated, there are still many unanswered questions and no universal agreements on how microbiome affects human health have been agreed upon. Consequently, this review was written to provide an updated overview of the rapidly expanding field, with a focus on revealing knowledge gaps and research opportunities. Specifically, the review covered animal physiology, optimal microbiome standard, health intervention by manipulating microbiome, knowledge base building by text mining, microbiota community structure and its implications in human diseases and health monitoring by analyzing microbiome in the blood. The review should enhance interest in conducting novel microbiota investigations that will further improve health and therapy.
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Metadata
Title
Involvement of gut microbiome in human health and disease: brief overview, knowledge gaps and research opportunities
Authors
Dachao Liang
Ross Ka-Kit Leung
Wenda Guan
William W. Au
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Gut Pathogens / Issue 1/2018
Electronic ISSN: 1757-4749
DOI
https://doi.org/10.1186/s13099-018-0230-4

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