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Critical Care
Published in: Critical Care 1/2016

Open Access 01-12-2016 | Research

What is the value of regional cerebral saturation in post-cardiac arrest patients? A prospective observational study

Authors: Cornelia Genbrugge, Ward Eertmans, Ingrid Meex, Margaretha Van Kerrebroeck, Noami Daems, An Creemers, Frank Jans, Willem Boer, Jo Dens, Cathy De Deyne

Published in: Critical Care | Issue 1/2016

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Abstract

Background

The aim of this study was to elucidate the possible role of cerebral saturation monitoring in the post-cardiac arrest setting.

Methods

Cerebral tissue saturation (SctO2) was measured in 107 successfully resuscitated out-of-hospital cardiac arrest patients for 48 hours between 2011 and 2015. All patients were treated with targeted temperature management, 24 hours at 33 °C and rewarming at 0.3 °C per hour. A threshold analysis was performed as well as a linear mixed models analysis for continuous SctO2 data to compare the relation between SctO2 and favorable (cerebral performance category (CPC) 1–2) and unfavorable outcome (CPC 3–4–5) at 180 days post-cardiac arrest in OHCA patients.

Results

Of the 107 patients, 50 (47 %) had a favorable neurological outcome at 180 days post-cardiac arrest. Mean SctO2 over 48 hours was 68 % ± 4 in patients with a favorable outcome compared to 66 % ± 5 for patients with an unfavorable outcome (p = 0.035). No reliable SctO2 threshold was able to predict favorable neurological outcome. A significant different course of SctO2 was observed, represented by a logarithmic and linear course of SctO2 in patients with favorable outcome and unfavorable outcome, respectively (p < 0.001). During the rewarming phase, significant higher SctO2 values were observed in patients with a favorable neurological outcome (p = 0.046).

Conclusions

This study represents the largest post-resuscitation cohort evaluated using NIRS technology, including a sizeable cohort of balloon-assisted patients. Although a significant difference was observed in the overall course of SctO2 between OHCA patients with a favorable and unfavorable outcome, the margin was too small to likely represent functional outcome differentiation based on SctO2 alone. As such, these results given such methodology as performed in this study suggest that NIRS is insufficient by itself to serve in outcome prognostication, but there may remain benefit when incorporated into a multi-neuromonitoring bedside assessment algorithm.
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Metadata
Title
What is the value of regional cerebral saturation in post-cardiac arrest patients? A prospective observational study
Authors
Cornelia Genbrugge
Ward Eertmans
Ingrid Meex
Margaretha Van Kerrebroeck
Noami Daems
An Creemers
Frank Jans
Willem Boer
Jo Dens
Cathy De Deyne
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2016
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-016-1509-9

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