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Published in: Critical Care 1/2015

01-12-2015 | Review

Starling curves and central venous pressure

Authors: David A Berlin, Jan Bakker

Published in: Critical Care | Issue 1/2015

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Abstract

Recent studies challenge the utility of central venous pressure monitoring as a surrogate for cardiac preload. Starting with Starling’s original studies on the regulation of cardiac output, this review traces the history of the experiments that elucidated the role of central venous pressure in circulatory physiology. Central venous pressure is an important physiologic parameter, but it is not an independent variable that determines cardiac output.
Literature
1.
go back to reference Patterson SW, Starling EH. On the mechanical factors which determine the output of the ventricles. J Physiol. 1914;48:357–79.CrossRef Patterson SW, Starling EH. On the mechanical factors which determine the output of the ventricles. J Physiol. 1914;48:357–79.CrossRef
2.
go back to reference Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39:165–228.CrossRef Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012. Intensive Care Med. 2013;39:165–228.CrossRef
3.
go back to reference Funk DJ, Kumar A. If the central venous pressure is [x], call me … maybe. Crit Care Med. 2013;41:1823–4.CrossRef Funk DJ, Kumar A. If the central venous pressure is [x], call me … maybe. Crit Care Med. 2013;41:1823–4.CrossRef
4.
go back to reference Shippy CR, Appel PL, Shoemaker WC. Reliability of clinical monitoring to assess blood volume in critically ill patients. Crit Care Med. 1984;12:107–12.CrossRef Shippy CR, Appel PL, Shoemaker WC. Reliability of clinical monitoring to assess blood volume in critically ill patients. Crit Care Med. 1984;12:107–12.CrossRef
5.
go back to reference Marik PE, Baram M, Vahid B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. CHEST J. 2008;134:172–8.CrossRef Marik PE, Baram M, Vahid B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. CHEST J. 2008;134:172–8.CrossRef
6.
go back to reference Marik PE, Cavallazzi R. Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense. Crit Care Med. 2013;41:1774–81.CrossRef Marik PE, Cavallazzi R. Does the central venous pressure predict fluid responsiveness? An updated meta-analysis and a plea for some common sense. Crit Care Med. 2013;41:1774–81.CrossRef
7.
go back to reference Durairaj L, Schmidt GA. Fluid therapy in resuscitated sepsis: less is more. Chest. 2008;133:252–63.CrossRef Durairaj L, Schmidt GA. Fluid therapy in resuscitated sepsis: less is more. Chest. 2008;133:252–63.CrossRef
8.
go back to reference Henderson J. A Life of Ernest Starling. New York: published for the American Physiological Society by Oxford University Press; 2005.CrossRef Henderson J. A Life of Ernest Starling. New York: published for the American Physiological Society by Oxford University Press; 2005.CrossRef
9.
go back to reference Guyton AC, Jones CE, Coleman TG. Circulatory Physiology: Cardiac Output and its Regulation. 2nd ed. Philadelphia, PA: Saunders; 1973. Guyton AC, Jones CE, Coleman TG. Circulatory Physiology: Cardiac Output and its Regulation. 2nd ed. Philadelphia, PA: Saunders; 1973.
10.
go back to reference Starling EH. The Linacre Lecture on the Law of the Heart. London: Longmans, Green, & Company; 1918. Starling EH. The Linacre Lecture on the Law of the Heart. London: Longmans, Green, & Company; 1918.
11.
go back to reference Daly IDB. The Second Bayliss–Starling Memorial Lecture. Some aspects of their separate and combined research interests. J Physiol. 1967;191:1.CrossRef Daly IDB. The Second Bayliss–Starling Memorial Lecture. Some aspects of their separate and combined research interests. J Physiol. 1967;191:1.CrossRef
12.
go back to reference Sarnoff SJ, Berglund E. Ventricular function: I. Starling's Law of the Heart studied by means of simultaneous right and left ventricular function curves in the dog. Circulation. 1954;9:706–18.CrossRef Sarnoff SJ, Berglund E. Ventricular function: I. Starling's Law of the Heart studied by means of simultaneous right and left ventricular function curves in the dog. Circulation. 1954;9:706–18.CrossRef
13.
go back to reference Isaacs JP, Berglund E, Sarnoff SJ. Ventricular function: III. The pathologic physiology of acute cardiac tamponade studied by means of ventricular function curves. Am Heart J. 1954;48:66–76.CrossRef Isaacs JP, Berglund E, Sarnoff SJ. Ventricular function: III. The pathologic physiology of acute cardiac tamponade studied by means of ventricular function curves. Am Heart J. 1954;48:66–76.CrossRef
14.
go back to reference Sarnoff SJ. Myocardial contractility as described by ventricular function curves; observations on Starling's Law of the Heart. Physiol Rev. 1955;35:107–22.CrossRef Sarnoff SJ. Myocardial contractility as described by ventricular function curves; observations on Starling's Law of the Heart. Physiol Rev. 1955;35:107–22.CrossRef
15.
go back to reference Braunwald E. The control of ventricular function in man. Br Heart J. 1965;27:1.CrossRef Braunwald E. The control of ventricular function in man. Br Heart J. 1965;27:1.CrossRef
16.
go back to reference Rushmer RF. Applicability of Starling's Law of the Heart to intact, unanesthetized animals. Physiol Rev. 1955;35:138–42.CrossRef Rushmer RF. Applicability of Starling's Law of the Heart to intact, unanesthetized animals. Physiol Rev. 1955;35:138–42.CrossRef
17.
go back to reference Berlin DA, Bakker J. Understanding venous return. Intensive Care Med. 2014;40:1564–6.CrossRef Berlin DA, Bakker J. Understanding venous return. Intensive Care Med. 2014;40:1564–6.CrossRef
18.
go back to reference Berlin D. Hemodynamic consequences of auto-PEEP. J Intensive Care Med. 2014;29:81–6.CrossRef Berlin D. Hemodynamic consequences of auto-PEEP. J Intensive Care Med. 2014;29:81–6.CrossRef
19.
go back to reference Forrester JS, Diamond G, McHugh TJ, Swan HJC. Filling pressures in the right and left sides of the heart in acute myocardial infarction. N Engl J Med. 1971;285:190–3.CrossRef Forrester JS, Diamond G, McHugh TJ, Swan HJC. Filling pressures in the right and left sides of the heart in acute myocardial infarction. N Engl J Med. 1971;285:190–3.CrossRef
20.
go back to reference Damman K, van Deursen VM, Navis G, Voors AA, van Veldhuisen DJ, Hillege HL. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J Am Coll Cardiol. 2009;53:582–8.CrossRef Damman K, van Deursen VM, Navis G, Voors AA, van Veldhuisen DJ, Hillege HL. Increased central venous pressure is associated with impaired renal function and mortality in a broad spectrum of patients with cardiovascular disease. J Am Coll Cardiol. 2009;53:582–8.CrossRef
21.
go back to reference van Deursen VM, Damman K, Hillege HL, van Beek AP, van Veldhuisen DJ, Voors AA. Abnormal liver function in relation to hemodynamic profile in heart failure patients. J Card Fail. 2010;16:84–90.CrossRef van Deursen VM, Damman K, Hillege HL, van Beek AP, van Veldhuisen DJ, Voors AA. Abnormal liver function in relation to hemodynamic profile in heart failure patients. J Card Fail. 2010;16:84–90.CrossRef
22.
go back to reference Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol. 2009;53:589–96.CrossRef Mullens W, Abrahams Z, Francis GS, Sokos G, Taylor DO, Starling RC, et al. Importance of venous congestion for worsening of renal function in advanced decompensated heart failure. J Am Coll Cardiol. 2009;53:589–96.CrossRef
23.
go back to reference Bock JS, Gottlieb SS. Cardiorenal syndrome: new perspectives. Circulation. 2010;121:2592–600.CrossRef Bock JS, Gottlieb SS. Cardiorenal syndrome: new perspectives. Circulation. 2010;121:2592–600.CrossRef
24.
go back to reference Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011;39:259–65.CrossRef Boyd JH, Forbes J, Nakada TA, Walley KR, Russell JA. Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality. Crit Care Med. 2011;39:259–65.CrossRef
25.
go back to reference Legrand M, Dupuis C, Simon C, Gayat E, Mateo J, Lukaszewicz AC, et al. Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Crit Care. 2013;17:R278.CrossRef Legrand M, Dupuis C, Simon C, Gayat E, Mateo J, Lukaszewicz AC, et al. Association between systemic hemodynamics and septic acute kidney injury in critically ill patients: a retrospective observational study. Crit Care. 2013;17:R278.CrossRef
26.
go back to reference Vieillard-Baron A, Prin S, Chergui K, Dubourg O, Jardin F. Echo-Doppler demonstration of acute cor pulmonale at the bedside in the medical intensive care unit. Am J Respir Crit Care Med. 2002;166:1310–9.CrossRef Vieillard-Baron A, Prin S, Chergui K, Dubourg O, Jardin F. Echo-Doppler demonstration of acute cor pulmonale at the bedside in the medical intensive care unit. Am J Respir Crit Care Med. 2002;166:1310–9.CrossRef
27.
go back to reference Mebazaa A, Karpati P, Renaud E, Algotsson L. Acute right ventricular failure – from pathophysiology to new treatments. Intensive Care Med. 2004;30:185–96.CrossRef Mebazaa A, Karpati P, Renaud E, Algotsson L. Acute right ventricular failure – from pathophysiology to new treatments. Intensive Care Med. 2004;30:185–96.CrossRef
28.
go back to reference Guyton AC, Lindsey AW, Gilluly JJ. The limits of right ventricular compensation following acute increase in pulmonary circulatory resistance. Circulat Res. 1954;2:326–32.CrossRef Guyton AC, Lindsey AW, Gilluly JJ. The limits of right ventricular compensation following acute increase in pulmonary circulatory resistance. Circulat Res. 1954;2:326–32.CrossRef
29.
go back to reference Jardin F, Vieillard-Baron A. Ultrasonographic examination of the venae cavae. Intensive Care Med. 2006;32:203–6.CrossRef Jardin F, Vieillard-Baron A. Ultrasonographic examination of the venae cavae. Intensive Care Med. 2006;32:203–6.CrossRef
30.
go back to reference Guyton AC, Hall JE. Textbook of Medical Physiology. 11th ed. Philadelphia, PA: Elsevier Saunders; 2006. Guyton AC, Hall JE. Textbook of Medical Physiology. 11th ed. Philadelphia, PA: Elsevier Saunders; 2006.
Metadata
Title
Starling curves and central venous pressure
Authors
David A Berlin
Jan Bakker
Publication date
01-12-2015
Publisher
BioMed Central
Published in
Critical Care / Issue 1/2015
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/s13054-015-0776-1

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