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Journal of Hematology & Oncology
Published in: Journal of Hematology & Oncology 1/2020

01-12-2020 | Acute Lymphoblastic Leukemia | Review

Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions

Authors: Bachar Samra, Elias Jabbour, Farhad Ravandi, Hagop Kantarjian, Nicholas J. Short

Published in: Journal of Hematology & Oncology | Issue 1/2020

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Abstract

Recent years have witnessed major advances that have improved outcome of adults with acute lymphoblastic leukemia (ALL). The emergence of the concept of measurable residual disease has fine-tuned our prognostic models and guided our treatment decisions. The treatment paradigms of ALL have been revolutionized with the advent of tyrosine kinase inhibitors targeting BCR-ABL1, monoclonal antibodies targeting CD20 (rituximab), antibody-drug conjugates targeting CD22 (inotuzumab ozogamicin), bispecific antibodies (blinatumomab), and CD19 chimeric antigen receptor T cell therapy (tisagenlecleucel). These highly effective new agents are allowing for novel approaches that reduce reliance on intensive cytotoxic chemotherapy and hematopoietic stem cell transplantation in first remission. This comprehensive review will focus on the recent advances and future directions in novel therapeutic strategies in adult ALL.
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Metadata
Title
Evolving therapy of adult acute lymphoblastic leukemia: state-of-the-art treatment and future directions
Authors
Bachar Samra
Elias Jabbour
Farhad Ravandi
Hagop Kantarjian
Nicholas J. Short
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Journal of Hematology & Oncology / Issue 1/2020
Electronic ISSN: 1756-8722
DOI
https://doi.org/10.1186/s13045-020-00905-2

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