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Open Access 01-12-2021 | Myocardial Infarction | Review

Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Authors: Fuwen Huang, Jingting Mai, Jingwei Chen, Yinying He, Xiaojun Chen

Published in: Journal of Cardiothoracic Surgery | Issue 1/2021

Abstract

The myocardial infarction is the main cause of morbidity and mortality in cardiovascular diseases around the world. Although the timely and complete reperfusion via Percutaneous Coronary Intervention (PCI) or thrombolysis have distinctly decreased the mortality of myocardial infarction, reperfusion itself may lead to supererogatory irreversible myocardial injury and heart function disorders, namely ischemia-reperfusion (I/R) injury. Extensive studies have indicated that non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs), play important roles in the progress of myocardial I/R injury, which is closely correlative with cardiomyocytes autophagy. Moreover, autophagy plays an important role in maintaining homeostasis and protecting cells in the myocardial ischemia reperfusion and cardiomyocyte hypoxia-reoxygenation (H/R) progress. In this review, we first introduced the biogenesis and functions of ncRNAs, and subsequently summarized the roles and relevant molecular mechanisms of ncRNAs regulating autophagy in myocardial I/R injury. We hope that this review in addition to develop a better understanding of the physiological and pathological roles of ncRNAs, can also lay a foundation for the therapies of myocardial I/R injury, and even for other related cardiovascular diseases.

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Title: Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review
Authors: Fuwen Huang
Jingting Mai
Jingwei Chen
Yinying He
Xiaojun Chen
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Myocardial Infarction
Published in: Journal of Cardiothoracic Surgery / Issue 1/2021
Electronic ISSN: 1749-8090
DOI: https://doi.org/10.1186/s13019-021-01524-9

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Non-coding RNAs modulate autophagy in myocardial ischemia-reperfusion injury: a systematic review

Abstract

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