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Journal of Orthopaedic Surgery and Research
Published in: Journal of Orthopaedic Surgery and Research 1/2022

Open Access 01-12-2022 | Bone Defect | Research

The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds

Authors: Marjan Bahraminasab, Athar Talebi, Nesa Doostmohammadi, Samaneh Arab, Ali Ghanbari, Sam Zarbakhsh

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2022

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Abstract

In this paper, the in-vivo healing of critical-sized bony defects by cell-free and stem cell-seeded 3D-printed PLA scaffolds was studied in rat calvaria bone. The scaffolds were implanted in the provided defect sites and histological analysis was conducted after 8 and 12 weeks. The results showed that both cell-free and stem cell-seeded scaffolds exhibited superb healing compared with the empty defect controls, and new bone and connective tissues were formed in the healing site after 8 and 12 weeks, postoperatively. The higher filled area, bone formation and bone maturation were observed after 12 weeks, particularly for PLA + Cell scaffolds.
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Metadata
Title
The healing of bone defects by cell-free and stem cell-seeded 3D-printed PLA tissue-engineered scaffolds
Authors
Marjan Bahraminasab
Athar Talebi
Nesa Doostmohammadi
Samaneh Arab
Ali Ghanbari
Sam Zarbakhsh
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Bone Defect
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2022
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-022-03213-2

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