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Journal of Orthopaedic Surgery and Research

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Open Access 01-12-2021 | Growth Factors | Research article

The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model

Authors: Murat Gurger, Gokhan Once, Erhan Yilmaz, Sukru Demir, Ilknur Calik, Yakup Say, Ahmet Kavakli, Sefa Key, Mustafa Umit Gurbuz, Onur Bingollu

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2021

Abstract

Background

The aim of this study is to histologically and biomechanically investigate the effects of local PRP and ozone therapy (O₂O₃) on tendon-to-bone healing in a rabbit model of the supraspinatus tendon tear.

Methods

Four groups were formed to have seven rabbits in each group: repair, R; repair + PRP, RP; repair + ozone, RO; and repair + PRP + ozone, RPO. The supraspinatus tendon was detached by sharp dissection from the footprint and an acute tear pattern was created. Thereafter, tendon repair was performed with the transosseous technique. In the RP group, PRP, and in the RPO group, PRP + O2O3 mixture was injected to the tendon repair site. In the RO group, O₂O₃ gas mixture was injected into subacromial space three times a week for a total of 4 weeks. The study was ended at postoperative 6th week.

Results

When compared with the R group, a statistically significant increase was observed in the biomechanical strength of the RP and RPO groups. The highest increase in biomechanical strength was detected in the RPO group. The histology of the RO and RPO groups showed better collagen fiber continuity and orientation than the R and RP groups.

Conclusions

The results obtained from this study show that the ozonized PRP can be used as biological support to increase tendon-to-bone healing. However, these results need to be supported by clinical studies.

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Title: The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model
Authors: Murat Gurger
Gokhan Once
Erhan Yilmaz
Sukru Demir
Ilknur Calik
Yakup Say
Ahmet Kavakli
Sefa Key
Mustafa Umit Gurbuz
Onur Bingollu
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Growth Factors
Growth Factors
Published in: Journal of Orthopaedic Surgery and Research / Issue 1/2021
Electronic ISSN: 1749-799X
DOI: https://doi.org/10.1186/s13018-021-02320-w

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The effect of the platelet-rich plasma and ozone therapy on tendon-to-bone healing in the rabbit rotator cuff repair model

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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