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Scoliosis and Spinal Disorders
Published in: Scoliosis and Spinal Disorders 1/2016

Open Access 01-12-2016 | Review

Genetics and pathogenesis of idiopathic scoliosis

Authors: A. Grauers, E. Einarsdottir, P. Gerdhem

Published in: Scoliosis and Spinal Disorders | Issue 1/2016

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Abstract

Idiopathic scoliosis (IS), the most common spinal deformity, affects otherwise healthy children and adolescents during growth. The aetiology is still unknown, although genetic factors are believed to be important. The present review corroborates the understanding of IS as a complex disease with a polygenic background. Presumably IS can be due to a spectrum of genetic risk variants, ranging from very rare or even private to very common. The most promising candidate genes are highlighted.
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Metadata
Title
Genetics and pathogenesis of idiopathic scoliosis
Authors
A. Grauers
E. Einarsdottir
P. Gerdhem
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Scoliosis and Spinal Disorders / Issue 1/2016
Electronic ISSN: 2397-1789
DOI
https://doi.org/10.1186/s13013-016-0105-8

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