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Diagnostic Pathology

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Open Access 01-12-2017 | Case Report

Primary mediastinal clear cell sarcoma: a case report and review of the literature

Authors: Long Jin, Yuxia Sui, Haili Zhu, Zhizhong Chen, Shuguang Liu

Published in: Diagnostic Pathology | Issue 1/2017

Abstract

Background

Clear cell sarcoma (CCS) is a rare malignant soft-tissue neoplasm that displays melanocytic markers and exhibits striking histopathological features. The tumour has a predilection for the lower extremities and rarely presents in the mediastinum.

Case presentation

We present a case of primary mediastinal CCS in a 57-year-old man. Computer tomography (CT) revealed a 12 × 12 × 7.5 cm mass in the anterior mediastinum. Microscopically, the tumour mainly consisted of epithelioid cells with oval vesicular nuclei and eosinophilic cytoplasm. Immunohistochemically, the tumour was positive for human melanoma black 45 (HMB-45) and vimentin but negative for S-100 and Melan-A. Fluorescence in situ hybridisation (FISH) showed a translocation involving the EWSR1 gene region.

Conclusion

This report will illustrate that the mediastinum is a potential site for primary CCS and FISH plays an important role in making a conclusive diagnosis.

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Title: Primary mediastinal clear cell sarcoma: a case report and review of the literature
Authors: Long Jin
Yuxia Sui
Haili Zhu
Zhizhong Chen
Shuguang Liu
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Diagnostic Pathology / Issue 1/2017
Electronic ISSN: 1746-1596
DOI: https://doi.org/10.1186/s13000-016-0594-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Primary mediastinal clear cell sarcoma: a case report and review of the literature

Abstract

Background

Case presentation

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusion

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