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Published in: Diagnostic Pathology 1/2016

Open Access 01-12-2016 | Case Report

Adenocarcinoma of the cervix involving the fallopian tube mucosa: report of a case

Authors: Chelsey D. Deel, Richard A. Allen, Laura L. Holman, Rosemary E. Zuna

Published in: Diagnostic Pathology | Issue 1/2016

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Abstract

Background

Fallopian tube involvement by cervical carcinoma has rarely been documented, with literature reports focusing primarily on squamous cell carcinoma.

Case presentation

In this report, we present the case of a 50 year old woman who presented with an abnormal Pap test with atypical squamous and glandular cells. A loop electrosurgical excision procedure (LEEP) was performed and led to the diagnosis of stage IB1 endocervical adenocarcinoma. Subsequent radical hysterectomy, bilateral salpingo-oophorectomy, and bilateral pelvic lymph node dissection showed a well-differentiated endocervical adenocarcinoma of usual type with superficial spread to the endometrium and right fallopian tube. The patient received no adjuvant therapy and has remained without evidence of disease.

Conclusions

While the advent of more extensive fallopian tube sampling has led to increased discovery and discussion of fallopian tube involvement by metastatic carcinoma, its impact on treatment and prognosis remains to be seen.
Literature
1.
go back to reference Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int J Gynecol Cancer. 2009;19:58–64.CrossRefPubMed Salvador S, Gilks B, Köbel M, Huntsman D, Rosen B, Miller D. The fallopian tube: primary site of most pelvic high-grade serous carcinomas. Int J Gynecol Cancer. 2009;19:58–64.CrossRefPubMed
2.
go back to reference Shanesmith R, Allen RA, Moore WE, Kingma DW, Caughron SK, Gillies EM, Dunn ST. Comparison of two line blot assays for defining HPV genotypes in oral and oropharyngeal squamous cells carcinomas. Diagn Microbiol Infect Dis. 2011;70:240–5.CrossRefPubMed Shanesmith R, Allen RA, Moore WE, Kingma DW, Caughron SK, Gillies EM, Dunn ST. Comparison of two line blot assays for defining HPV genotypes in oral and oropharyngeal squamous cells carcinomas. Diagn Microbiol Infect Dis. 2011;70:240–5.CrossRefPubMed
3.
go back to reference SEER Stat Fact Sheets. Cervix Uteri Cancer. SEER: Surveillance, Epidemiology, and End Results Program [database online]. Bethesda: National Cancer Institute; 1996. SEER Stat Fact Sheets. Cervix Uteri Cancer. SEER: Surveillance, Epidemiology, and End Results Program [database online]. Bethesda: National Cancer Institute; 1996.
4.
go back to reference Wang SS, Sherman ME, Hildesheim A, et al. Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000. Cancer. 2004;100(5):1035–44.CrossRefPubMed Wang SS, Sherman ME, Hildesheim A, et al. Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976–2000. Cancer. 2004;100(5):1035–44.CrossRefPubMed
5.
go back to reference Smith HO, Tiffany MF, Qualls CR, Key CR. The rising incidence of adenocarcinoma relative to squamous cell carcinoma of the uterine cervix in the United States-A 24-year population-based study. Gynecol Oncol. 2000;78:97–105.CrossRefPubMed Smith HO, Tiffany MF, Qualls CR, Key CR. The rising incidence of adenocarcinoma relative to squamous cell carcinoma of the uterine cervix in the United States-A 24-year population-based study. Gynecol Oncol. 2000;78:97–105.CrossRefPubMed
6.
go back to reference Gungor T, Altinkaya SO, Ozat M, et al. Unusual form of superficial spreading squamous cell carcinoma of cervix involving the endometrium, bilateral tubes and ovaries: a case report with literature review. Arch Gynecol Obstet. 2011;283:323–7.CrossRefPubMed Gungor T, Altinkaya SO, Ozat M, et al. Unusual form of superficial spreading squamous cell carcinoma of cervix involving the endometrium, bilateral tubes and ovaries: a case report with literature review. Arch Gynecol Obstet. 2011;283:323–7.CrossRefPubMed
7.
go back to reference Jaiman S, Surampudi K, Gundabattula SR, Garg D. Bilateral ovarian metastatic squamous cell carcinoma arising from the uterine cervix and eluding the Mullerian mucosa. Diagn Pathol. 2014;9:109.CrossRefPubMedPubMedCentral Jaiman S, Surampudi K, Gundabattula SR, Garg D. Bilateral ovarian metastatic squamous cell carcinoma arising from the uterine cervix and eluding the Mullerian mucosa. Diagn Pathol. 2014;9:109.CrossRefPubMedPubMedCentral
8.
go back to reference Nakanishi T, Wakai K, Ishikawa H, et al. A Comparison of ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol. 2001;82:504–9.CrossRefPubMed Nakanishi T, Wakai K, Ishikawa H, et al. A Comparison of ovarian metastasis between squamous cell carcinoma and adenocarcinoma of the uterine cervix. Gynecol Oncol. 2001;82:504–9.CrossRefPubMed
9.
go back to reference Reyes C, Murali R, Park KJ. Secondary involvement of the adnexa and uterine corpus by carcinomas of the uterine cervix. A detailed morphologic description. Int J Gynecol Pathol. 2015;34(6):551–63.CrossRefPubMed Reyes C, Murali R, Park KJ. Secondary involvement of the adnexa and uterine corpus by carcinomas of the uterine cervix. A detailed morphologic description. Int J Gynecol Pathol. 2015;34(6):551–63.CrossRefPubMed
10.
go back to reference Rabban JT, Vohra P, Zaloudek CJ. Nongynecologic metastases to fallopian tube mucosa: a potential mimic of tubal high-grade serous carcinoma and benign tubal mucinous metaplasia or nonmucinous hyperplasia. Am J Surg Pathol. 2015;39(1):35–51.CrossRefPubMed Rabban JT, Vohra P, Zaloudek CJ. Nongynecologic metastases to fallopian tube mucosa: a potential mimic of tubal high-grade serous carcinoma and benign tubal mucinous metaplasia or nonmucinous hyperplasia. Am J Surg Pathol. 2015;39(1):35–51.CrossRefPubMed
11.
go back to reference Ronnett BM, Yemelyanova AV, Vang R, et al. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol. 2008;32(12):1835–53.CrossRefPubMed Ronnett BM, Yemelyanova AV, Vang R, et al. Endocervical adenocarcinomas with ovarian metastases: analysis of 29 cases with emphasis on minimally invasive cervical tumors and the ability of the metastases to simulate primary ovarian neoplasms. Am J Surg Pathol. 2008;32(12):1835–53.CrossRefPubMed
12.
go back to reference Hashi A, Yuminamochi T, Murata S, et al. Wilms tumor gene immunoreactivity in primary serous carcinomas of the fallopian tube, ovary, endometrium and peritoneum. Int J Gynecologic Pathol. 2003;22(4):374–7.CrossRef Hashi A, Yuminamochi T, Murata S, et al. Wilms tumor gene immunoreactivity in primary serous carcinomas of the fallopian tube, ovary, endometrium and peritoneum. Int J Gynecologic Pathol. 2003;22(4):374–7.CrossRef
14.
go back to reference Singh N, Gilks CB, Wilkinson N, McCluggage WG. Assessment of a new system for primary site assignment in high-grade serous carcinoma of the fallopian tube, ovary, and peritoneum. Histopathology. 2015;67(3):331–7.CrossRefPubMed Singh N, Gilks CB, Wilkinson N, McCluggage WG. Assessment of a new system for primary site assignment in high-grade serous carcinoma of the fallopian tube, ovary, and peritoneum. Histopathology. 2015;67(3):331–7.CrossRefPubMed
15.
go back to reference Protocol for the Examination of Specimens from Patients with Carcinoma of the Uterine Cervix. College of American Pathologists Cancer Protocol Templates. December 2013. Available at: http://www.cap.org/CANCERPROTOCOLS. Accessed 23 June 2015. Protocol for the Examination of Specimens from Patients with Carcinoma of the Uterine Cervix. College of American Pathologists Cancer Protocol Templates. December 2013. Available at: http://​www.​cap.​org/​CANCERPROTOCOLS. Accessed 23 June 2015.
Metadata
Title
Adenocarcinoma of the cervix involving the fallopian tube mucosa: report of a case
Authors
Chelsey D. Deel
Richard A. Allen
Laura L. Holman
Rosemary E. Zuna
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Diagnostic Pathology / Issue 1/2016
Electronic ISSN: 1746-1596
DOI
https://doi.org/10.1186/s13000-016-0529-8

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