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Reproductive Health
Published in: Reproductive Health 1/2023

Open Access 01-12-2023 | Premature Birth | Research

Association between season of conception, month of conception with preterm birth in China: a population-based retrospective cohort study

Authors: Yu Wu, Hanfeng Ye, Yanling Yuan, Cai Kong, Wenzhan Jing, Jue Liu, Min Liu

Published in: Reproductive Health | Issue 1/2023

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Abstract

Background

Seasonal patterns of preterm birth were identified in previous studies, but the effect of conception season on preterm birth has not been extensively studied. Based on the notion that the etiological roots of preterm birth lie in the beginning of pregnancy, we did a population-based retrospective cohort study in Southwest China to examine the effects of season of conception and month of conception on preterm birth.

Methods

We did a population-based retrospective cohort study in women (aged 18–49) who participated in the NFPHEP from 2010 to 2018, and had a singleton livebirth in southwest China. According to the time of the last menstruation reported by the participants, month of conception and season of conception were then ascertained. We used multivariate log-binomial model to adjust the potential risk factors for preterm birth and obtained adjusted risk ratio (aRR) and 95% confidence intervals (95%CI) for conception season, conception month and preterm birth.

Results

Among 194 028 participants, 15 034 women had preterm birth. Compared with pregnancies that were conceived in the summer, pregnancies that were conceived in the spring, autumn and winter had the higher risk of preterm birth (Spring: aRR = 1.10, 95% CI: 1.04–1.15; Autumn: aRR = 1.14, 95% CI: 1.09–1.20; Winter: aRR = 1.28, 95% CI: 1.22–1.34) and also had a higher risk of early preterm birth (Spring: aRR = 1.09, 95% CI: 1.01–1.18; Autumn: aRR = 1.09, 95% CI: 1.01–1.19; Winter: aRR = 1.16, 95% CI: 1.08–1.25). Pregnancies in December, and January had a higher risk of preterm birth and early preterm birth than pregnancies that were conceived in July.

Conclusions

Our study found that preterm birth was significantly related to season of conception. Preterm and early preterm birth rates were the highest among pregnancies that were conceived in winter, and the lowest among pregnancies in summer.
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Metadata
Title
Association between season of conception, month of conception with preterm birth in China: a population-based retrospective cohort study
Authors
Yu Wu
Hanfeng Ye
Yanling Yuan
Cai Kong
Wenzhan Jing
Jue Liu
Min Liu
Publication date
01-12-2023
Publisher
BioMed Central
Keyword
Premature Birth
Published in
Reproductive Health / Issue 1/2023
Electronic ISSN: 1742-4755
DOI
https://doi.org/10.1186/s12978-023-01636-6

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