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Journal of Neuroinflammation
Published in: Journal of Neuroinflammation 1/2022

Open Access 01-12-2022 | Chronic Inflammatory Bowel Disease | Review

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

Authors: Colin F. Craig, Rhiannon T. Filippone, Rhian Stavely, Joel C. Bornstein, Vasso Apostolopoulos, Kulmira Nurgali

Published in: Journal of Neuroinflammation | Issue 1/2022

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Abstract

Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological trigger of depressive symptoms is theorised to be inflammation within the central nervous system. It is believed that heightened intestinal inflammation and dysfunction of the enteric nervous system (ENS) contribute to impaired intestinal permeability, which facilitates the translocation of intestinal enterotoxins into the blood circulation. Consequently, these may compromise the immunological and physiological functioning of distant non-intestinal tissues such as the brain. In vivo models of colitis provide evidence of increased blood–brain barrier permeability and enhanced central nervous system (CNS) immune activity triggered by intestinal enterotoxins and blood-borne inflammatory mediators. Understanding the immunological, physiological, and structural changes associated with IBD and neuroinflammation may aid in the development of more tailored and suitable pharmaceutical treatment for IBD-associated depression.
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Metadata
Title
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease
Authors
Colin F. Craig
Rhiannon T. Filippone
Rhian Stavely
Joel C. Bornstein
Vasso Apostolopoulos
Kulmira Nurgali
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Journal of Neuroinflammation / Issue 1/2022
Electronic ISSN: 1742-2094
DOI
https://doi.org/10.1186/s12974-021-02354-1

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Dysregulated B cell differentiation towards antibody-secreting cells in neuromyelitis optica spectrum disorder

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CXCL13 expressed on inflamed cerebral blood vessels recruit IL-21 producing TFH cells to damage neurons following stroke

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Electrical stimulation of the splenic nerve bundle ameliorates dextran sulfate sodium-induced colitis in mice

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Association of inflammatory markers with cerebral small vessel disease in community-based population