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Journal of Cardiovascular Magnetic Resonance

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Open Access 01-12-2022 | Research

Normal sex and age-specific parameters in a multi-ethnic population: a cardiovascular magnetic resonance study of the Canadian Alliance for Healthy Hearts and Minds cohort

Authors: Judy M. Luu, Catherine Gebhard, Chinthanie Ramasundarahettige, Dipika Desai, Karleen Schulze, Francois Marcotte, Philip Awadalla, Philippe Broet, Trevor Dummer, Jason Hicks, Eric Larose, Alan Moody, Eric E. Smith, Jean-Claude Tardif, Tiago Teixeira, Koon K. Teo, Jennifer Vena, Douglas S. Lee, Sonia S. Anand, Matthias G. Friedrich, the CAHHM Study Investigators

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2022

Abstract

Background

Despite the growing utility of cardiovascular magnetic resonance (CMR) for cardiac morphology and function, sex and age-specific normal reference values derived from large, multi-ethnic data sets are lacking. Furthermore, most available studies use a simplified tracing methodology. Using a large cohort of participants without history of cardiovascular disease (CVD) or risk factors from the Canadian Alliance for Healthy Heart and Minds, we sought to establish a robust set of reference values for ventricular and atrial parameters using an anatomically correct contouring method, and to determine the influence of age and sex on ventricular parameters.

Methods and results

Participants (n = 3206, 65% females; age 55.2 ± 8.4 years for females and 55.1 ± 8.8 years for men) underwent CMR using standard methods for quantitative measurements of cardiac parameters. Normal ventricular and atrial reference values are provided: (1) for males and females, (2) stratified by four age categories, and (3) for different races/ethnicities. Values are reported as absolute, indexed to body surface area, or height. Ventricular volumes and mass were significantly larger for males than females (p < 0.001). Ventricular ejection fraction was significantly diminished in males as compared to females (p < 0.001). Indexed left ventricular (LV) end-systolic, end-diastolic volumes, mass and right ventricular (RV) parameters significantly decreased as age increased for both sexes (p < 0.001). For females, but not men, mean LV and RVEF significantly increased with age (p < 0.001).

Conclusion

Using anatomically correct contouring methodology, we provide accurate sex and age-specific normal reference values for CMR parameters derived from the largest, multi-ethnic population free of CVD to date.

Clinical trial registration

ClinicalTrials.gov, NCT02220582. Registered 20 August 2014—Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT02220582.

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Title: Normal sex and age-specific parameters in a multi-ethnic population: a cardiovascular magnetic resonance study of the Canadian Alliance for Healthy Hearts and Minds cohort
Authors: Judy M. Luu
Catherine Gebhard
Chinthanie Ramasundarahettige
Dipika Desai
Karleen Schulze
Francois Marcotte
Philip Awadalla
Philippe Broet
Trevor Dummer
Jason Hicks
Eric Larose
Alan Moody
Eric E. Smith
Jean-Claude Tardif
Tiago Teixeira
Koon K. Teo
Jennifer Vena
Douglas S. Lee
Sonia S. Anand
Matthias G. Friedrich
the CAHHM Study Investigators
Publication date: 01-12-2022
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue 1/2022
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/s12968-021-00819-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Normal sex and age-specific parameters in a multi-ethnic population: a cardiovascular magnetic resonance study of the Canadian Alliance for Healthy Hearts and Minds cohort

Abstract

Background

Methods and results

Conclusion

Clinical trial registration

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods and results

Conclusion

Clinical trial registration

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