Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2023

Open Access 01-12-2023 | Gastric Cancer | Research

The value of lymph nodes ratios in the prognosis of resectable remnant gastric cancer through the retrospective propensity score matching analysis

Authors: Biao Yang, Tao Liu, Hangtian Cui, Zhengmao Lu, Guoen Fang, Xuchao Xue, Tianhang Luo

Published in: World Journal of Surgical Oncology | Issue 1/2023

Login to get access

Abstract

Purpose

Currently, the characteristics and prognosis of remnant gastric cancer (RGC) are not fully understood yet. The present study aimed to describe the details of clinicopathological features of resectable RGC and investigated the factors affecting survival after the curative operation.

Methods

From Jan. 2006 to Dec. 2015, a total of 118 resectable RGC patients (the RGC group) and 236 age-, sex- and TNM stages-matched resectable gastric cancer (GC) patients (the control group) were recruited retrospectively. Clinicopathological characteristics and overall survival were compared between the two groups.

Results

The overall survival rate was 46.61% for RGC patients compared to 55.08% for control groups (P < 0.01), and the mean overall survival time of RGC patients was 40.23 ± 32.27 months, compared to 55.06 ± 34.29 months in the control group (P = 0.023 after matching). The overall survival (OS) of RGC patients with stage IIb was much worse than IIa (P < 0.001) and similar to IIIa (P = 0.463) and IIIb (P = 0.014). Multivariate Cox proportional hazards model analysis revealed that TNM stage (HR: 3.899, P < 0.001) and lymph nodes ratio (LNR) (HR: 2.405, P = 0.028) were independent prognostic significance to OS.

Conclusions

The OS of RGC was much worse than GC with similar TNM stages, and LNR might consider a highly reliable indicator to evaluate the prognostic in RGC.
Literature
1.
2.
Kung CY, Fang WL, Wang RF, et al. Prognosis and clinicopathologic features in patients with gastric stump cancer after curative surgery. Curr Oncol. 2020;27(3):e259–64.CrossRefPubMedPubMedCentral
3.
Mak TK, Guan B, Peng J, et al. Prevalence and characteristics of gastric remnant cancer: A systematic review and meta-analysis. Asian J Surg. 2021;44(1):11–7.CrossRefPubMed
4.
Kidokoro T, Hayashida Y, Urabe M. Long-term surgical results of carcinoma of the gastric remnant: a statistical analysis of 613 patients from 98 institutions. World J Surg. 1985;9(6):966–71.CrossRefPubMed
5.
Japanese Gastric Cancer A. Japanese Classification of Gastric Carcinoma - 2nd English Edition. Gastric Cancer. 1998;1(1):10–24.
6.
Nozaki I, Hato S, Kobatake T, et al. Incidence of metachronous gastric cancer in the remnant stomach after synchronous multiple cancer surgery. Gastric Cancer. 2014;17(1):61–6.CrossRefPubMed
7.
Gao Z, Jiang K, Ye Y, et al. Interpretation on Chinese surgeons’ consensus opinion for the definition of gastric stump cancer (version 2018). Zhonghua Wei Chang Wai Ke Za Zhi. 2018;21(5):486–90.PubMed
8.
Hanyu T, Wakai A, Ishikawa T, et al. Carcinoma in the Remnant Stomach During Long-Term Follow-up After Distal Gastrectomy for Gastric Cancer: Analysis of Cumulative Incidence and Associated Risk Factors. World J Surg. 2018;42(3):782–7.CrossRefPubMed
9.
10.
Song XH, Liu K, Sun LF, et al. Clinicopathological characteristics and prognostic factors of remnant gastric cancer: A single-center retrospective analysis of 90 patients. Int J Surg. 2018;51:97–103.
11.
Galata C, Ronellenfitsch U, Weiss C, et al. Surgery for Gastric Remnant Cancer Results in Similar Overall Survival Rates Compared with Primary Gastric Cancer: A Propensity Score-Matched Analysis. Ann Surg Oncol. 2020;27(11):4196–203.CrossRefPubMedPubMedCentral
12.
Irino T, Hiki N, Ohashi M, et al. Characteristics of gastric stump cancer: A single hospital retrospective analysis of 262 patients. Surgery. 2016;159(6):1539–47.CrossRefPubMed
13.
Takeno S, Hashimoto T, Maki K, et al. Gastric cancer arising from the remnant stomach after distal gastrectomy: a review. World J Gastroenterol. 2014;20(38):13734–40.CrossRefPubMedPubMedCentral
14.
Ramos M, Pereira MA, de Castria TB, et al. Remnant gastric cancer: a neglected group with high potential for immunotherapy. J Cancer Res Clin Oncol. 2020;146(12):3373–83.CrossRefPubMed
15.
Bafutto AAF, Castro OAP, Fukuhara DK, et al. Lymph node distribution in patients with remnant gastric cancer. J Cancer Res Clin Oncol. 2023;149(6):2367–74.CrossRefPubMed
16.
Kavaliauskas P, Dulskas A, Kavaliauskaite R, et al. Short and long-term outcomes in a patient cohort with gastric stump cancer: A propensity score analysis. Asian J Surg. 2021;44(7):1027–8.CrossRefPubMed
17.
Tanigawa N, Nomura E, Lee SW, et al. Current state of gastric stump carcinoma in Japan: based on the results of a nationwide survey. World J Surg. 2010;34(7):1540–7.CrossRefPubMedPubMedCentral
18.
Tran TB, Hatzaras I, Worhunsky DJ, et al. Gastric remnant cancer: A distinct entity or simply another proximal gastric cancer? J Surg Oncol. 2015;112(8):877–82.CrossRefPubMed
19.
Hu X, Tian DY, Cao L, et al. Progression and prognosis of gastric stump cancer. J Surg Oncol. 2009;100(6):472–6.CrossRefPubMed
20.
An JY, Youn HG, Ha TK, et al. Clinical significance of tumor location in remnant gastric cancers developed after partial gastrectomy for primary gastric cancer. J Gastrointest Surg. 2008;12(4):689–94.CrossRefPubMed
21.
Zhang DW, Dong B, Li Z, et al. Clinicopathologic features of remnant gastric cancer over time following distal gastrectomy. World J Gastroenterol. 2015;21(19):5972–8.CrossRefPubMedPubMedCentral
22.
Namikawa T, Kitagawa H, Iwabu J, et al. Tumors arising at previous anastomotic site may have poor prognosis in patients with gastric stump cancer following gastrectomy. J Gastrointest Surg. 2010;14(12):1923–30.CrossRefPubMed
23.
Takahashi M, Takeuchi H, Tsuwano S, et al. Surgical Resection of Remnant Gastric Cancer Following Distal Gastrectomy: A Retrospective Clinicopathological Study. Ann Surg Oncol. 2016;23(2):511–21.CrossRefPubMed
24.
Nakagawa M, Choi YY, An JY, et al. Staging for Remnant Gastric Cancer: The Metastatic Lymph Node Ratio vs. the UICC 7th Edition System. Ann Surg Oncol. 2016;23(13):4322–31.
25.
Washington K. 7th edition of the AJCC cancer staging manual: stomach. Ann Surg Oncol. 2010;17(12):3077–9.CrossRefPubMed
26.
Nienhuser H, Blank S, Sisic L, et al. Gastric stump carcinoma: frequency, treatment, complications and prognosis. Chirurg. 2017;88(4):317–27.PubMed
27.
Liao G, Wen S, Xie X, et al. Laparoscopic gastrectomy for remnant gastric cancer: Risk factors associated with conversion and a systematic analysis of literature. Int J Surg. 2016;34:17–22.
28.
29.
Mezhir JJ, Gonen M, Ammori JB, et al. Treatment and outcome of patients with gastric remnant cancer after resection for peptic ulcer disease. Ann Surg Oncol. 2011;18(3):670–6.CrossRefPubMed
30.
An JY, Choi MG, Noh JH, et al. The outcome of patients with remnant primary gastric cancer compared with those having upper one-third gastric cancer. Am J Surg. 2007;194(2):143–7.CrossRefPubMed
31.
Irino T, Hiki N, Nunobe S, et al. Subtotal gastrectomy with limited lymph node dissection is a feasible treatment option for patients with early gastric stump cancer. J Gastrointest Surg. 2014;18(8):1429–33.CrossRefPubMed
32.
Ahn HS, Lee HJ, Hahn S, et al. Evaluation of the seventh American Joint Committee on Cancer/International Union Against Cancer Classification of gastric adenocarcinoma in comparison with the sixth classification. Cancer. 2010;116(24):5592–8.CrossRefPubMed
33.
Ataseven B, Grimm C, Harter P, et al. Prognostic value of lymph node ratio in patients with advanced epithelial ovarian cancer. Gynecol Oncol. 2014;135(3):435–40.CrossRefPubMed
34.
Taylor MD, Lapar DJ, Thomas CJ, et al. Lymph node ratio predicts recurrence and survival after R0 resection for non-small cell lung cancer. Ann Thorac Surg. 2013;96(4):1163–70.CrossRefPubMed
35.
Hou X, Wei JC, Xu Y, et al. The positive lymph node ratio predicts long-term survival in patients with operable thoracic esophageal squamous cell carcinoma in China. Ann Surg Oncol. 2013;20(5):1653–9.CrossRefPubMed
36.
Okusa T, Nakane Y, Boku T, et al. Quantitative analysis of nodal involvement with respect to survival rate after curative gastrectomy for carcinoma. Surg Gynecol Obstet. 1990;170(6):488–94.PubMed
Metadata
Title
The value of lymph nodes ratios in the prognosis of resectable remnant gastric cancer through the retrospective propensity score matching analysis
Authors
Biao Yang
Tao Liu
Hangtian Cui
Zhengmao Lu
Guoen Fang
Xuchao Xue
Tianhang Luo
Publication date
01-12-2023
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2023
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-023-03137-z

Other articles of this Issue 1/2023

World Journal of Surgical Oncology 1/2023 Go to the issue

Research

Determining the precise extent of sentinel basins during laparoscopic gastrectomy for early gastric cancer

Case Report

McKeown esophagectomy for a thoracic esophageal carcinoma patient who has a history of definitive chemoradiotherapy for esophageal carcinoma and total pharyngolaryngectomy for hypopharyngeal cancer

Research

Thromboelastography (TEG) parameters as potential predictors of malignancy and tumor progression in colorectal cancer

Research

Prognostic analysis of 2–5 cm diameter gastric stromal tumors with exogenous or endogenous growth

Research

Impact of endoscopic metallic stent placement and emergency surgery on detection of viable circulating tumor cells for acute malignant left-sided colonic obstruction

Research

A meta-analysis of the efficacy of Roux-en-Y anastomosis and jejunal interposition after total gastrectomy