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World Journal of Surgical Oncology

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Open Access 01-12-2021 | Pituitary Adenoma | Review

Research advances on the immune research and prospect of immunotherapy in pituitary adenomas

Authors: Ding Nie, Qiuyue Fang, Bin Li, Jianhua Cheng, Chuzhong Li, Songbai Gui, Yazhuo Zhang, Peng Zhao

Published in: World Journal of Surgical Oncology | Issue 1/2021

Abstract

Background

Pituitary adenomas are one type of intracranial tumor, which can be divided into microadenoma (≤ 1 cm), macroadenoma (> 1 cm), and giant adenoma (≥ 4 cm) according to their diametral sizes. They are benign, typically slow-progressing, whereas the biological behavior of some of them is invasive, which presents a major clinical challenge. Treatment of some pituitary adenomas is still difficult due to drug resistance or multiple relapses, usually after surgery, medication, and radiation. At present, no clear prediction and treatment biomarkers have been found in pituitary adenomas and some of them do not cause clinical symptoms, so patients are often found to be ill through physical examination, and some are even found through autopsy. With the development of research on pituitary adenomas, the immune response has become a hot spot and may serve as a novel disease marker and therapeutic target.

The distribution and function of immune cells and their secreted molecules in pituitary adenomas are extremely complex. Researchers found that infiltration of immune cells may have a positive effect on the treatment and prognosis of pituitary adenomas. In this review, we summarized the advance of tumor immunity in pituitary adenomas, revealing the immunity molecules as potential biomarkers as well as therapeutic agents for pituitary adenomas.

Conclusion

The immune studies related to pituitary adenomas may help us find relevant immune markers. At the same time, the exploration of immunotherapy also provides new options for the treatment of pituitary adenomas.

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Title: Research advances on the immune research and prospect of immunotherapy in pituitary adenomas
Authors: Ding Nie
Qiuyue Fang
Bin Li
Jianhua Cheng
Chuzhong Li
Songbai Gui
Yazhuo Zhang
Peng Zhao
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Pituitary Adenoma
Published in: World Journal of Surgical Oncology / Issue 1/2021
Electronic ISSN: 1477-7819
DOI: https://doi.org/10.1186/s12957-021-02272-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Research advances on the immune research and prospect of immunotherapy in pituitary adenomas

Abstract

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Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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