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World Journal of Surgical Oncology
Published in: World Journal of Surgical Oncology 1/2015

Open Access 01-12-2015 | Review

Metastatic liver disease from non-colorectal, non-neuroendocrine, non-sarcoma cancers: a systematic review

Authors: Fabio Uggeri, Paolo Alessandro Ronchi, Paolo Goffredo, Mattia Garancini, Luca Degrate, Luca Nespoli, Luca Gianotti, Fabrizio Romano

Published in: World Journal of Surgical Oncology | Issue 1/2015

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Abstract

Background

Hepatic resection of liver metastases of non-colorectal, non-neuroendocrine, and non-sarcoma (NCNNNS) primary malignancies seems to improve survival in selected patients. The aims of the current review were to describe long-term results of surgery and to evaluate prognostic factors for survival in patients who underwent resection of NCNNNS liver metastases.

Methods

We identified 30 full texts (25 single-center and 5 multicenter studies) published after year 1995 and published in English with a total of 3849 patients. For NCNNNS liver metastases, 83.4 % of these subjects were resected.

Results

No prior systematic reviews or meta-analyses on this topic were identified. All studies were case series without matching control groups. The most common primary sites were breast (23.8 %), genito-urinary (21.8 %), and gastrointestinal tract (19.8 %). The median 5- and 10-year overall survival were 32.3 % (range 19–42 %) and 24 % (indicated only in two studies, range 23–25 %), respectively, with 71 % of R0 resections.

Conclusions

There is evidence suggesting that surgery of NCNNNS metastases is safe, feasible, and effective if treatment is part of a multidisciplinary approach and if indication is based on the prognostic factors underlined in literature analysis.
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Metadata
Title
Metastatic liver disease from non-colorectal, non-neuroendocrine, non-sarcoma cancers: a systematic review
Authors
Fabio Uggeri
Paolo Alessandro Ronchi
Paolo Goffredo
Mattia Garancini
Luca Degrate
Luca Nespoli
Luca Gianotti
Fabrizio Romano
Publication date
01-12-2015
Publisher
BioMed Central
Published in
World Journal of Surgical Oncology / Issue 1/2015
Electronic ISSN: 1477-7819
DOI
https://doi.org/10.1186/s12957-015-0606-6

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