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Molecular Cancer
Published in: Molecular Cancer 1/2018

Open Access 01-12-2018 | Review

Role of the NLRP3 inflammasome in cancer

Authors: Maryam Moossavi, Negin Parsamanesh, Afsane Bahrami, Stephen L. Atkin, Amirhossein Sahebkar

Published in: Molecular Cancer | Issue 1/2018

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Abstract

Inflammasomes are large intracellular multi-protein signalling complexes that are formed in the cytosolic compartment as an inflammatory immune response to endogenous danger signals. The formation of the inflammasome enables activation of an inflammatory protease caspase-1, pyroptosis initiation with the subsequent cleaving of the pro-inflammatory cytokines interleukin (IL)-1β and proIL-18 to produce active forms. The inflammasome complex consists of a Nod-like receptor (NLR), the adapter apoptosis-associated speck-like (ASC) protein, and Caspase-1. Dysregulation of NLRP3 inflammasome activation is involved tumor pathogenesis, although its role in cancer development and progression remains controversial due to the inconsistent findings described. In this review, we summarize the current knowledge on the contribution of the NLRP3 inflammasome on potential cancer promotion and therapy.
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Metadata
Title
Role of the NLRP3 inflammasome in cancer
Authors
Maryam Moossavi
Negin Parsamanesh
Afsane Bahrami
Stephen L. Atkin
Amirhossein Sahebkar
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Molecular Cancer / Issue 1/2018
Electronic ISSN: 1476-4598
DOI
https://doi.org/10.1186/s12943-018-0900-3

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