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Published in: Malaria Journal 1/2017

Open Access 01-12-2017 | Research

Incidence, prevalence and mortality rates of malaria in Ethiopia from 1990 to 2015: analysis of the global burden of diseases 2015

Authors: Amare Deribew, Tariku Dejene, Biruck Kebede, Gizachew Assefa Tessema, Yohannes Adama Melaku, Awoke Misganaw, Teshome Gebre, Asrat Hailu, Sibhatu Biadgilign, Alemayehu Amberbir, Biruck Desalegn Yirsaw, Amanuel Alemu Abajobir, Oumer Shafi, Semaw F. Abera, Nebiyu Negussu, Belete Mengistu, Azmeraw T. Amare, Abate Mulugeta, Birhan Mengistu, Zerihun Tadesse, Mesfin Sileshi, Elizabeth Cromwell, Scott D. Glenn, Kebede Deribe, Jeffrey D. Stanaway

Published in: Malaria Journal | Issue 1/2017

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Abstract

Background

In Ethiopia there is no complete registration system to measure disease burden and risk factors accurately. In this study, the 2015 global burden of diseases, injuries and risk factors (GBD) data were used to analyse the incidence, prevalence and mortality rates of malaria in Ethiopia over the last 25 years.

Methods

GBD 2015 used verbal autopsy surveys, reports, and published scientific articles to estimate the burden of malaria in Ethiopia. Age and gender-specific causes of death for malaria were estimated using cause of death ensemble modelling.

Results

The number of new cases of malaria declined from 2.8 million [95% uncertainty interval (UI) 1.4–4.5 million] in 1990 to 621,345 (95% UI 462,230–797,442) in 2015. Malaria caused an estimated 30,323 deaths (95% UI 11,533.3–61,215.3) in 1990 and 1561 deaths (95% UI 752.8–2660.5) in 2015, a 94.8% reduction over the 25 years. Age-standardized mortality rate of malaria has declined by 96.5% between 1990 and 2015 with an annual rate of change of 13.4%. Age-standardized malaria incidence rate among all ages and gender declined by 88.7% between 1990 and 2015. The number of disability-adjusted life years lost (DALY) due to malaria decreased from 2.2 million (95% UI 0.76–4.7 million) in 1990 to 0.18 million (95% UI 0.12–0.26 million) in 2015, with a total reduction 91.7%. Similarly, age-standardized DALY rate declined by 94.8% during the same period.

Conclusions

Ethiopia has achieved a 50% reduction target of malaria of the millennium development goals. The country should strengthen its malaria control and treatment strategies to achieve the sustainable development goals.
Literature
3.
go back to reference Abeku TA, Helinski ME, Kirby MJ, Kefyalew T, Awano T, Batisso E, et al. Monitoring changes in malaria epidemiology and effectiveness of interventions in Ethiopia and Uganda: beyond Garki project baseline survey. Malar J. 2015;14:337.CrossRefPubMedPubMedCentral Abeku TA, Helinski ME, Kirby MJ, Kefyalew T, Awano T, Batisso E, et al. Monitoring changes in malaria epidemiology and effectiveness of interventions in Ethiopia and Uganda: beyond Garki project baseline survey. Malar J. 2015;14:337.CrossRefPubMedPubMedCentral
4.
go back to reference Aregawi M, Lynch M, Bekele W, Kebede H, Jima D, Taffese HS, et al. Time series analysis of trends in malaria cases and deaths at hospitals and the effect of antimalarial interventions, 2001–2011, Ethiopia. PLoS ONE. 2014;9:e106359.CrossRefPubMedPubMedCentral Aregawi M, Lynch M, Bekele W, Kebede H, Jima D, Taffese HS, et al. Time series analysis of trends in malaria cases and deaths at hospitals and the effect of antimalarial interventions, 2001–2011, Ethiopia. PLoS ONE. 2014;9:e106359.CrossRefPubMedPubMedCentral
5.
go back to reference Yimer F, Animut A, Erko B, Mamo H. Past five-year trend, current prevalence and household knowledge, attitude and practice of malaria in Abeshge, south-central Ethiopia. Malar J. 2015;14:230.CrossRefPubMedPubMedCentral Yimer F, Animut A, Erko B, Mamo H. Past five-year trend, current prevalence and household knowledge, attitude and practice of malaria in Abeshge, south-central Ethiopia. Malar J. 2015;14:230.CrossRefPubMedPubMedCentral
7.
go back to reference Adhanom T, Witten HK, Getachew A, Seboxa T. Malaria. In: Berhane Y, Hailemariam D, Kloos H, editors. The epidemiology and ecology of health and disease in Ethiopia. Addis Ababa: Shama PLC; 2006. p. 556–76. Adhanom T, Witten HK, Getachew A, Seboxa T. Malaria. In: Berhane Y, Hailemariam D, Kloos H, editors. The epidemiology and ecology of health and disease in Ethiopia. Addis Ababa: Shama PLC; 2006. p. 556–76.
8.
go back to reference Deribew A, Tessema GA, Deribe K, Melaku YA, Lakew Y, Amare AT, et al. Trends, causes, and risk factors of mortality among children under 5 in Ethiopia, 1990–2013: findings from the Global Burden of Disease Study 2013. Popul Health Metr. 2016;14:42.CrossRefPubMedPubMedCentral Deribew A, Tessema GA, Deribe K, Melaku YA, Lakew Y, Amare AT, et al. Trends, causes, and risk factors of mortality among children under 5 in Ethiopia, 1990–2013: findings from the Global Burden of Disease Study 2013. Popul Health Metr. 2016;14:42.CrossRefPubMedPubMedCentral
11.
go back to reference Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095–128.CrossRefPubMed Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380:2095–128.CrossRefPubMed
12.
go back to reference GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–71.CrossRef GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2015;385:117–71.CrossRef
13.
go back to reference Murray CJ, Ortblad KF, Guinovart C, Lim SS, Wolock TM, Roberts DA, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:1005–70.CrossRefPubMedPubMedCentral Murray CJ, Ortblad KF, Guinovart C, Lim SS, Wolock TM, Roberts DA, et al. Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:1005–70.CrossRefPubMedPubMedCentral
14.
go back to reference Wang H, Liddell CA, Coates MM, Mooney MD, Levitz CE, Schumacher AE, et al. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:957–79.CrossRefPubMedPubMedCentral Wang H, Liddell CA, Coates MM, Mooney MD, Levitz CE, Schumacher AE, et al. Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet. 2014;384:957–79.CrossRefPubMedPubMedCentral
16.
go back to reference Federal Ministry of Health. National strategic plan for malaria prevention, control and elimination in Ethiopia: 2014–2020. Addis Ababa: Addis Ababa; 2014. Federal Ministry of Health. National strategic plan for malaria prevention, control and elimination in Ethiopia: 2014–2020. Addis Ababa: Addis Ababa; 2014.
18.
go back to reference Murray CJ, Ezzati M, Flaxman AD, Lim S, Lozano R, Michaud C, et al. GBD 2010: design, definitions, and metrics. Lancet. 2012;380:2063–6.CrossRefPubMed Murray CJ, Ezzati M, Flaxman AD, Lim S, Lozano R, Michaud C, et al. GBD 2010: design, definitions, and metrics. Lancet. 2012;380:2063–6.CrossRefPubMed
19.
go back to reference GBD 2013 DALYs and HALE Collaborators, Murray CJ, Barber RM, Foreman KJ, Ozgoren AA, et al. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. Lancet. 2015;386:2145–91.CrossRefPubMedCentral GBD 2013 DALYs and HALE Collaborators, Murray CJ, Barber RM, Foreman KJ, Ozgoren AA, et al. Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition. Lancet. 2015;386:2145–91.CrossRefPubMedCentral
20.
go back to reference GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1603–58.CrossRef GBD 2015 DALYs and HALE Collaborators. Global, regional, and national disability-adjusted life-years (DALYs) for 315 diseases and injuries and healthy life expectancy (HALE), 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388:1603–58.CrossRef
22.
24.
go back to reference Yassin MA, Datiko DG, Tulloch O, Markos P, Aschalew M, Shargie EB, et al. Innovative community-based approaches doubled tuberculosis case notification and improve treatment outcome in Southern Ethiopia. PLoS ONE. 2013;8:e63174.CrossRefPubMedPubMedCentral Yassin MA, Datiko DG, Tulloch O, Markos P, Aschalew M, Shargie EB, et al. Innovative community-based approaches doubled tuberculosis case notification and improve treatment outcome in Southern Ethiopia. PLoS ONE. 2013;8:e63174.CrossRefPubMedPubMedCentral
25.
go back to reference Deribew A, Birhanu Z, Sena L, Dejene T, Reda AA, Sudhakar M, et al. The effect of household heads training about the use of treated bed nets on the burden of malaria and anaemia in under-five children: a cluster randomized trial in Ethiopia. Malar J. 2012;11:8.CrossRefPubMedPubMedCentral Deribew A, Birhanu Z, Sena L, Dejene T, Reda AA, Sudhakar M, et al. The effect of household heads training about the use of treated bed nets on the burden of malaria and anaemia in under-five children: a cluster randomized trial in Ethiopia. Malar J. 2012;11:8.CrossRefPubMedPubMedCentral
26.
go back to reference Kibret S, Wilson GG, Ryder D, Tekie H, Petros B. Malaria impact of large dams at different eco-epidemiological settings in Ethiopia. Trop Med Health. 2017;45:4.CrossRefPubMedPubMedCentral Kibret S, Wilson GG, Ryder D, Tekie H, Petros B. Malaria impact of large dams at different eco-epidemiological settings in Ethiopia. Trop Med Health. 2017;45:4.CrossRefPubMedPubMedCentral
27.
go back to reference Yewhalaw D, Legesse W, Van Bortel W, Gebre-Selassie S, Kloos H, Duchateau L, et al. Malaria and water resource development: the case of Gilgel-Gibe hydroelectric dam in Ethiopia. Malar J. 2009;8:21.CrossRefPubMedPubMedCentral Yewhalaw D, Legesse W, Van Bortel W, Gebre-Selassie S, Kloos H, Duchateau L, et al. Malaria and water resource development: the case of Gilgel-Gibe hydroelectric dam in Ethiopia. Malar J. 2009;8:21.CrossRefPubMedPubMedCentral
29.
go back to reference Yewhalaw D, Wassie F, Steurbaut W, Spanoghe P, Van Bortel W, Denis L, et al. Multiple insecticide resistance: an impediment to insecticide-based malaria vector control program. PLoS ONE. 2011;6:e16066.CrossRefPubMedPubMedCentral Yewhalaw D, Wassie F, Steurbaut W, Spanoghe P, Van Bortel W, Denis L, et al. Multiple insecticide resistance: an impediment to insecticide-based malaria vector control program. PLoS ONE. 2011;6:e16066.CrossRefPubMedPubMedCentral
30.
go back to reference Mitiku I, Assefa A. Caregivers’ perception of malaria and treatment-seeking behaviour for under five children in Mandura District, West Ethiopia: a cross-sectional study. Malar J. 2017;16:144.CrossRefPubMedPubMedCentral Mitiku I, Assefa A. Caregivers’ perception of malaria and treatment-seeking behaviour for under five children in Mandura District, West Ethiopia: a cross-sectional study. Malar J. 2017;16:144.CrossRefPubMedPubMedCentral
31.
go back to reference Reyburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O, et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. BMJ. 2004;329:1212.CrossRefPubMedPubMedCentral Reyburn H, Mbatia R, Drakeley C, Carneiro I, Mwakasungula E, Mwerinde O, et al. Overdiagnosis of malaria in patients with severe febrile illness in Tanzania: a prospective study. BMJ. 2004;329:1212.CrossRefPubMedPubMedCentral
33.
go back to reference Shah NK, Dhariwal AC, Sonal GS, Gunasekar A, Dye C, Cibulskis R. Malaria-attributed death rates in India. Lancet. 2011;377:991 (author reply 994–5).CrossRefPubMed Shah NK, Dhariwal AC, Sonal GS, Gunasekar A, Dye C, Cibulskis R. Malaria-attributed death rates in India. Lancet. 2011;377:991 (author reply 994–5).CrossRefPubMed
Metadata
Title
Incidence, prevalence and mortality rates of malaria in Ethiopia from 1990 to 2015: analysis of the global burden of diseases 2015
Authors
Amare Deribew
Tariku Dejene
Biruck Kebede
Gizachew Assefa Tessema
Yohannes Adama Melaku
Awoke Misganaw
Teshome Gebre
Asrat Hailu
Sibhatu Biadgilign
Alemayehu Amberbir
Biruck Desalegn Yirsaw
Amanuel Alemu Abajobir
Oumer Shafi
Semaw F. Abera
Nebiyu Negussu
Belete Mengistu
Azmeraw T. Amare
Abate Mulugeta
Birhan Mengistu
Zerihun Tadesse
Mesfin Sileshi
Elizabeth Cromwell
Scott D. Glenn
Kebede Deribe
Jeffrey D. Stanaway
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Malaria Journal / Issue 1/2017
Electronic ISSN: 1475-2875
DOI
https://doi.org/10.1186/s12936-017-1919-4

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