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Cancer Cell International
Published in: Cancer Cell International 1/2022

Open Access 01-12-2022 | Bladder Carcinoma | Review

Role of microRNA-34b-5p in cancer and injury: how does it work?

Authors: Xuechun Bai, Lianwen Zheng, Ying Xu, Yan Liang, Dandan Li

Published in: Cancer Cell International | Issue 1/2022

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Abstract

MicroRNAs (miRNAs or miRs) are a class of noncoding single-stranded RNAs that can regulate gene expression by binding to the untranslated sequences at the 3 ' end of messenger RNAs. The microRNA-34 family is dysregulated in various human diseases. It is considered as a tumor-suppressive microRNA because of its synergistic effect with the well-known tumor suppressor p53. As a member of the miRNA-34 family, miR-34b-5p serves as a powerful regulator of a suite of cellular activities, including cell growth, multiplication, development, differentiation, and apoptosis. It promotes or represses disease occurrence and progression by participating in some important signaling pathways. This review aimed to provide an overview and update on the differential expression and function of miR-34b-5p in pathophysiologic processes, especially cancer and injury. Additionally, miR-34b-5p‐mediated clinical trials have indicated promising consequences for the therapies of carcinomatosis and injury. With the application of the first tumor-targeted microRNA drug based on miR-34a mimics, it can be inferred that miR-34b-5p may become a crucial factor in the therapy of various diseases. However, further studies on miR-34b-5p should shed light on its involvement in disease pathogenesis and treatment options.
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Metadata
Title
Role of microRNA-34b-5p in cancer and injury: how does it work?
Authors
Xuechun Bai
Lianwen Zheng
Ying Xu
Yan Liang
Dandan Li
Publication date
01-12-2022
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2022
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-022-02797-3

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