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Cancer Cell International
Published in: Cancer Cell International 1/2020

01-12-2020 | Gastric Cancer | Review

Emerging roles of RNA methylation in gastrointestinal cancers

Authors: Shanshan Xie, Wenwen Chen, Kanghua Chen, Yongxia Chang, Feng Yang, Aifu Lin, Qiang Shu, Tianhua Zhou, Xiaoyi Yan

Published in: Cancer Cell International | Issue 1/2020

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Abstract

RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of biological properties, including N6-methyladenosine (m6A), 2-O-dimethyladenosine (m6Am), N1-methyladenosine (m1A), 5-methylcytosine (m5C) and 7-methyl guanosine (m7G). Dynamic and reversible methylation on RNA is mediated by RNA modifying proteins called “writers” (methyltransferases) and “erasers” (demethylases). “Readers” (modified RNA binding proteins) recognize and bind to RNA methylation sites, which influence the splicing, stability or translation of modified RNAs. Herein, we summarize the biological functions and mechanisms of these well-known RNA methylations, especially focusing on the roles of m6A in gastrointestinal cancer development.
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Metadata
Title
Emerging roles of RNA methylation in gastrointestinal cancers
Authors
Shanshan Xie
Wenwen Chen
Kanghua Chen
Yongxia Chang
Feng Yang
Aifu Lin
Qiang Shu
Tianhua Zhou
Xiaoyi Yan
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2020
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-020-01679-w

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