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Cancer Cell International

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Open Access 01-12-2014 | Primary research

Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis

Authors: Xianjun Lao, Qiliu Peng, Yu Lu, Shan Li, Xue Qin, Zhiping Chen, Junqiang Chen

Published in: Cancer Cell International | Issue 1/2014

Abstract

Background

The null genotype of GSTM1 have been implicated in gastric cancer risk, but numerous individual studies showed mixed, or even conflicting results. Thus, a meta-analysis was performed.

Results

We identified 54 individual studies involving 9,322 cases and 15,118 controls through computer-based searches of PubMed, Embase, and Cochrane Library. It was found that the null genotype of GSTM1 was associated with an increased gastric cancer risk (OR = 1.207, 95% CI: 1.106-1.317, P < 0.001), under the random-effects model (I² : 49.9%, P_Q <0.001). From stratification analyses for ethnicity, alcohol drinking, Helicobacter pylori infection, an effect modification of gastric cancer risk was found in the subgroups of ethnicity, smoking status, Helicobacter pylori infection, whereas null result was found in the subgroups of alcohol drinking. We also undertook gene-gene interaction analysis between GSTM1 and GSTT1 genes for gastric cancer risk, and the results indicated that the dual null genotypes of GSTM1 and GSTT1 might elevate the risk of gastric cancer (OR = 1.505, 95% CI: 1.165-1.944, P = 002).

Conclusions

This meta-analysis suggests that the null genotype of GSTM1 may be a important genetic risk factor for gastric cancer development.

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Title: Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis
Authors: Xianjun Lao
Qiliu Peng
Yu Lu
Shan Li
Xue Qin
Zhiping Chen
Junqiang Chen
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Cancer Cell International / Issue 1/2014
Electronic ISSN: 1475-2867
DOI: https://doi.org/10.1186/s12935-014-0127-3

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