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Cancer Cell International
Published in: Cancer Cell International 1/2014

Open Access 01-12-2014 | Primary research

Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes

Authors: GanLin He, ChunYan Wang, QingEn Li, Huo Tan, FuXiong Chen, ZhenQian Huang, BaoDan Yu, LiXia Zheng, RunHui Zheng, Dan Liu

Published in: Cancer Cell International | Issue 1/2014

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Abstract

Background

There is limited information on a special subtype of Acute myeloid leukemia (AML) characterized by >20% myeloblasts and >20% abnormal promyelocytes in bone marrow and peripheral blood.

Objective

The objective of the present investigation was to explore the clinical and laboratory features of seven patients with AML-M2/M3.

Method

We retrospectively assessed cell morphology, cytochemistry, immunophenotype, cytogenetics, and clinical features of seven patients with this rare subtype of AML.

Results

All seven cases had thrombocytopenia, coagulation abnormalities, >20% myeloblasts and abnormal promyelocytes. The PML/RARα fusion gene was present in six patients and two patients presented a mixed PML/RARα and AML1/ETO genotype. Five cases achieved CR and two cases did not achieve remission and one case transform into AML-M2 after CR1.

Conclusions

The clinical and laboratory features of seven patients with AML-M2/M3 are demonstrated in the present study, providing information on the FAB sub-classification.
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Metadata
Title
Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes
Authors
GanLin He
ChunYan Wang
QingEn Li
Huo Tan
FuXiong Chen
ZhenQian Huang
BaoDan Yu
LiXia Zheng
RunHui Zheng
Dan Liu
Publication date
01-12-2014
Publisher
BioMed Central
Published in
Cancer Cell International / Issue 1/2014
Electronic ISSN: 1475-2867
DOI
https://doi.org/10.1186/s12935-014-0111-y

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