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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2021

Open Access 01-12-2021 | Diabetic Retinopathy | Review

Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications

Authors: Bao Sun, Zhiying Luo, Jiecan Zhou

Published in: Cardiovascular Diabetology | Issue 1/2021

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Abstract

Diabetes mellitus is the major risk factor for the development of macrovascular and microvascular complications. It is increasingly recognized that glycemic variability (GV), referring to oscillations in blood glucose levels and representing either short-term or long-term GV, is involved in the pathogenesis of diabetic complications and has emerged as a possible independent risk factor for them. In this review, we summarize the metrics and measurement of GV in clinical practice, as well as comprehensively elaborate the role and related mechanisms of GV in diabetic macrovascular and microvascular complications, aiming to provide the mechanism-based therapeutic strategies for clinicians to manage diabetes mellitus.
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Metadata
Title
Comprehensive elaboration of glycemic variability in diabetic macrovascular and microvascular complications
Authors
Bao Sun
Zhiying Luo
Jiecan Zhou
Publication date
01-12-2021
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2021
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-020-01200-7

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