Skip to main content
Top
Published in: Cardiovascular Diabetology 1/2018

Open Access 01-12-2018 | Commentary

Unrecognised cardiovascular disease in type 2 diabetes: is it time to act earlier?

Authors: Guntram Schernthaner, Chaim Lotan, Elina Baltadzhieva-Trendafilova, Jonas Ceponis, Martin Clodi, Kristine Ducena, Eva Goncalvesova, Cristian Guja, Marek Honka, Andrej Janež, Nebojša Lalić, Roger Lehmann, Noémi Nyolczas, Priit Pauklin, Andrzej Rynkiewicz, Igor Sergienko, Lea Smirčić Duvnjak

Published in: Cardiovascular Diabetology | Issue 1/2018

Login to get access

Abstract

Cardiovascular disease (CVD) is the most significant prognostic factor in individuals with type 2 diabetes (T2D). However, a significant number of individuals may develop CVD that does not present with the classic angina-related or heart failure symptoms. In these cases, CVD may seem to be ‘silent’ or ‘asymptomatic’, but may be more accurately characterised as unrecognised diabetic cardiac impairment. An initial step to raise awareness of unrecognised CVD in individuals with T2D would be to reach a consensus regarding the terminology used to describe this phenomenon. By standardising the terminologies, and agreeing on the implementation of an efficient screening program, it is anticipated that patients will receive an earlier diagnosis and appropriate and timely treatment. Given the availability of anti-diabetic medications that have been shown to concomitantly reduce CV risk and mortality, it is imperative to improve early identification and initiate treatment as soon as possible in order to enable as many patients with T2D as possible to benefit.
Literature
1.
go back to reference Ditchburn CJ, Hall JA, de Belder M, Davies A, Kelly W, Bilous R. Silent myocardial ischaemia in patients with proved coronary artery disease: a comparison of diabetic and non-diabetic patients. Postgrad Med J. 2001;77:395–8.CrossRef Ditchburn CJ, Hall JA, de Belder M, Davies A, Kelly W, Bilous R. Silent myocardial ischaemia in patients with proved coronary artery disease: a comparison of diabetic and non-diabetic patients. Postgrad Med J. 2001;77:395–8.CrossRef
2.
go back to reference Makrilakis K, Liatis S. Cardiovascular Screening for the Asymptomatic Patient with Diabetes: more Cons Than Pros. J Diabetes Res. 2017;2017:8927473.CrossRef Makrilakis K, Liatis S. Cardiovascular Screening for the Asymptomatic Patient with Diabetes: more Cons Than Pros. J Diabetes Res. 2017;2017:8927473.CrossRef
3.
go back to reference Cohn PF, Fox KM, Daly C. Silent myocardial ischemia. Circulation. 2003;108(10):1263–77.CrossRef Cohn PF, Fox KM, Daly C. Silent myocardial ischemia. Circulation. 2003;108(10):1263–77.CrossRef
4.
go back to reference Davis TM, Coleman RL, Holman RR, Group U. Prognostic significance of silent myocardial infarction in newly diagnosed type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS) 79. Circulation. 2013;127:980–7.CrossRef Davis TM, Coleman RL, Holman RR, Group U. Prognostic significance of silent myocardial infarction in newly diagnosed type 2 diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS) 79. Circulation. 2013;127:980–7.CrossRef
5.
go back to reference Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L, Timmis A, Hemingway H. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015;3:105–13.CrossRef Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L, Timmis A, Hemingway H. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015;3:105–13.CrossRef
6.
go back to reference Dauriz M, Mantovani A, Bonapace S, Verlato G, Zoppini G, Bonora E, Targher G. Prognostic impact of diabetes on long-term survival outcomes in patients with heart failure: a meta-analysis. Diabetes Care. 2017;40:1597–605.CrossRef Dauriz M, Mantovani A, Bonapace S, Verlato G, Zoppini G, Bonora E, Targher G. Prognostic impact of diabetes on long-term survival outcomes in patients with heart failure: a meta-analysis. Diabetes Care. 2017;40:1597–605.CrossRef
7.
go back to reference Vinik AI, Erbas T, Casellini CM. Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease. J Diabetes Investig. 2013;4:4–18.CrossRef Vinik AI, Erbas T, Casellini CM. Diabetic cardiac autonomic neuropathy, inflammation and cardiovascular disease. J Diabetes Investig. 2013;4:4–18.CrossRef
8.
go back to reference Valensi P, Avignon A, Sultan A, Chanu B, Nguyen MT, Cosson E. Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol. 2016;15:104.CrossRef Valensi P, Avignon A, Sultan A, Chanu B, Nguyen MT, Cosson E. Atherogenic dyslipidemia and risk of silent coronary artery disease in asymptomatic patients with type 2 diabetes: a cross-sectional study. Cardiovasc Diabetol. 2016;15:104.CrossRef
9.
go back to reference American Diabetes A. Improving care and promoting health in populations: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S7–12.CrossRef American Diabetes A. Improving care and promoting health in populations: standards of medical care in diabetes-2018. Diabetes Care. 2018;41(Suppl 1):S7–12.CrossRef
10.
go back to reference Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129–200.CrossRef Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JG, Coats AJ, Falk V, Gonzalez-Juanatey JR, Harjola VP, Jankowska EA, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016;37:2129–200.CrossRef
Metadata
Title
Unrecognised cardiovascular disease in type 2 diabetes: is it time to act earlier?
Authors
Guntram Schernthaner
Chaim Lotan
Elina Baltadzhieva-Trendafilova
Jonas Ceponis
Martin Clodi
Kristine Ducena
Eva Goncalvesova
Cristian Guja
Marek Honka
Andrej Janež
Nebojša Lalić
Roger Lehmann
Noémi Nyolczas
Priit Pauklin
Andrzej Rynkiewicz
Igor Sergienko
Lea Smirčić Duvnjak
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2018
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-018-0788-7

Other articles of this Issue 1/2018

Cardiovascular Diabetology 1/2018 Go to the issue
Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin
Prof. Florian Limbourg
Prof. Anoop Chauhan
Developed by: Springer Medicine
Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine