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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2017

Open Access 01-12-2017 | Review

Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

Authors: Basil S. Karam, Alejandro Chavez-Moreno, Wonjoon Koh, Joseph G. Akar, Fadi G. Akar

Published in: Cardiovascular Diabetology | Issue 1/2017

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Abstract

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several risk factors promote AF, among which diabetes mellitus has emerged as one of the most important. The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to adverse atrial structural and electrical remodeling that leads to the onset and maintenance of AF in the diabetic heart. We then discuss several therapeutic strategies to improve atrial excitability by targeting pathways that control oxidative stress and inflammation.
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Metadata
Title
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes
Authors
Basil S. Karam
Alejandro Chavez-Moreno
Wonjoon Koh
Joseph G. Akar
Fadi G. Akar
Publication date
01-12-2017
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2017
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-017-0604-9

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