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Cardiovascular Diabetology
Published in: Cardiovascular Diabetology 1/2016

Open Access 01-12-2016 | Original investigation

The influence of body composition on renal function in patients with coronary artery disease and its prognostic significance: a retrospective cohort study

Authors: Yong Peng, Hua Wang, Fei Chen, Fang-yang Huang, Tian-li Xia, Yan-biao Liao, Hua Chai, Peng-ju Wang, Zhi-liang Zuo, Wei Liu, Chen Zhang, Yi-jian Li, Yi-yue Gui, Mao Chen, De-jia Huang

Published in: Cardiovascular Diabetology | Issue 1/2016

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Abstract

Objective

We try to analyse the effect of renal functions on death in CAD patients with different body compositions.

Methods

A retrospective analysis was conducted in 2989 consecutive patients with CAD confirmed by coronary angiography were enrolled and were grouped into two categories: basically preserved renal function (PRF) (eGFR ≥60 ml/min) and obviously reduced renal function (RRF) (eGFR <60 ml/min). The influence of renal insufficiency on mortality of CAD was detected in every tertile of body composition, including body mass index (BMI), body fat (BF) and lean mass index (LMI). The end points were all-cause mortality.

Results

The mean follow-up time was 29.1 ± 12.5 months and death events occurred in 271 cases. The percentage of patients with RRF was positively correlated with BF and inversely correlated with the LMI, but no relationship to BMI. The survival curves showed that the risk of death was significantly higher in the RRF patients in all subgroups stratified using BMI, BF, or LMI (log rank test, all p < 0.001). The COX multivariate regression analysis showed that the risk of death was significantly higher in the RRF patients with high BF (HR 1.95, CI 1.25–3.05) and low LMI (HR 1.82, CI 1.19–2.79). Meanwhile, risk of death was significantly higher in RRF patients with a high BMI (HR 2.08, CI 1.22–3.55) or low BMI (HR 1.98, CI 1.28–3.08) but this risk was not significant in patients with a medium BMI (HR 1.12, 0.65–1.94). The subgroup analysis of patients with acute coronary syndrome (ACS) showed similar results.

Conclusions

For patients with CAD, renal insufficiency was positively correlated with BF, inversely correlated with LMI, and unrelated to BMI. The effect of renal insufficiency on the risk of death of CAD was related to body composition.
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Metadata
Title
The influence of body composition on renal function in patients with coronary artery disease and its prognostic significance: a retrospective cohort study
Authors
Yong Peng
Hua Wang
Fei Chen
Fang-yang Huang
Tian-li Xia
Yan-biao Liao
Hua Chai
Peng-ju Wang
Zhi-liang Zuo
Wei Liu
Chen Zhang
Yi-jian Li
Yi-yue Gui
Mao Chen
De-jia Huang
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Cardiovascular Diabetology / Issue 1/2016
Electronic ISSN: 1475-2840
DOI
https://doi.org/10.1186/s12933-016-0420-7

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