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Respiratory Research
Published in: Respiratory Research 1/2020

Open Access 01-12-2020 | Tissue Plasminogen Activator | Letter to the Editor

Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19

Authors: Martin J. Tobin, Amal Jubran, Franco Laghi

Published in: Respiratory Research | Issue 1/2020

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Abstract

In the article “The pathophysiology of ‘happy’ hypoxemia in COVID-19,” Dhont et al. (Respir Res 21:198, 2020) discuss pathophysiological mechanisms that may be responsible for the absence of dyspnea in patients with COVID-19 who exhibit severe hypoxemia. The authors review well-known mechanisms that contribute to development of hypoxemia in patients with pneumonia, but are less clear as to why patients should be free of respiratory discomfort despite arterial oxygen levels commonly regarded as life threatening. The authors propose a number of therapeutic measures for patients with COVID-19 and happy hypoxemia; we believe readers should be alerted to problems with the authors’ interpretations and recommendations.
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Tobin MJ, Laghi F, Jubran A. Caution about early intubation and mechanical ventilation in COVID-19. Ann Intensive Care. 2020;10(1):78.CrossRef
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Tobin MJ, Laghi F, Jubran A. P-SILI is not justification for intubation of COVID-19 patients. Ann Intensive Care. 2020;10(1):105.CrossRef
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Laghi F, Tobin MJ. Indications for mechanical ventilation. In: Tobin MJ, editor. Principles and practice of mechanical ventilation. 3rd ed. New York: McGraw-Hill, Inc.; 2013. p. 101–35.
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Metadata
Title
Misconceptions of pathophysiology of happy hypoxemia and implications for management of COVID-19
Authors
Martin J. Tobin
Amal Jubran
Franco Laghi
Publication date
01-12-2020
Publisher
BioMed Central
Published in
Respiratory Research / Issue 1/2020
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/s12931-020-01520-y

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