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BMC Health Services Research
Published in: BMC Health Services Research 1/2020

01-12-2020 | Care | Study protocol

The cirrhosis care Alberta (CCAB) protocol: implementing an evidence-based best practice order set for the management of liver cirrhosis - a hybrid type I effectiveness-implementation trial

Authors: Michelle Carbonneau, Ejemai Amaize Eboreime, Ashley Hyde, Denise Campbell-Scherer, Peter Faris, Leah Gramlich, Ross T. Tsuyuki, Stephen E. Congly, Abdel Aziz Shaheen, Matthew Sadler, Marilyn Zeman, Jude Spiers, Juan G. Abraldes, Benjamin Sugars, Winnie Sia, Lee Green, Dalia Abdellatif, Jeffrey P. Schaefer, Vijeyakumar Selvarajah, Kaleb Marr, David Ryan, Yolande Westra, Neeja Bakshi, Jayant C. Varghese, Puneeta Tandon

Published in: BMC Health Services Research | Issue 1/2020

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Abstract

Background

Liver cirrhosis is a leading cause of morbidity, premature mortality and acute care utilization in patients with digestive disease. In the province of Alberta, hospital readmission rates for patients with cirrhosis are estimated at 44% at 90 days. For hospitalized patients, multiple care gaps exist, the most notable stemming from i) the lack of a structured approach to best practice care for cirrhosis complications, ii) the lack of a structured approach to broader health needs and iii) suboptimal preparation for transition of care into the community. Cirrhosis Care Alberta (CCAB) is a 4-year multi-component pragmatic trial which aims to address these gaps. The proposed intervention is initiated at the time of hospitalization through implementation of a clinical information system embedded electronic order set for delivering evidence-based best practices under real-world conditions. The overarching objective of the CCAB trial is to demonstrate effectiveness and implementation feasibility for use of the order set in routine patient care within eight hospital sites in Alberta.

Methods

A mixed methods hybrid type I effectiveness-implementation design will be used to evaluate the effectiveness of the order set intervention. The primary outcome is a reduction in 90-day cumulative length of stay. Implementation outcomes such as reach, adoption, fidelity and maintenance will also be evaluated alongside other patient and service outcomes such as readmission rates, quality of care and cost-effectiveness. This theory-based trial will be guided by Normalization Process Theory, Consolidated Framework on Implementation Research (CFIR) and the Reach-Effectiveness-Adoption-Implementation-Maintenance (RE-AIM) Framework.

Discussion

The CCAB project is unique in its breadth, both in the comprehensiveness of the multi-component order set and also for the breadth of its roll-out. Lessons learned will ultimately inform the feasibility and effectiveness of this approach in “real-world” conditions as well as adoption and adaptation of these best practices within the rest of Alberta, other provinces in Canada, and beyond.

Trial registration

Appendix
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Metadata
Title
The cirrhosis care Alberta (CCAB) protocol: implementing an evidence-based best practice order set for the management of liver cirrhosis - a hybrid type I effectiveness-implementation trial
Authors
Michelle Carbonneau
Ejemai Amaize Eboreime
Ashley Hyde
Denise Campbell-Scherer
Peter Faris
Leah Gramlich
Ross T. Tsuyuki
Stephen E. Congly
Abdel Aziz Shaheen
Matthew Sadler
Marilyn Zeman
Jude Spiers
Juan G. Abraldes
Benjamin Sugars
Winnie Sia
Lee Green
Dalia Abdellatif
Jeffrey P. Schaefer
Vijeyakumar Selvarajah
Kaleb Marr
David Ryan
Yolande Westra
Neeja Bakshi
Jayant C. Varghese
Puneeta Tandon
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Health Services Research / Issue 1/2020
Electronic ISSN: 1472-6963
DOI
https://doi.org/10.1186/s12913-020-05427-8

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