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BMC Clinical Pathology
Published in: BMC Clinical Pathology 1/2017

Open Access 01-12-2017 | Research article

Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer

Authors: Ayşe Latif, Amy L. Chadwick, Sarah J. Kitson, Hannah J. Gregson, Vanitha N. Sivalingam, James Bolton, Rhona J. McVey, Stephen A. Roberts, Kay M. Marshall, Kaye J. Williams, Ian J. Stratford, Emma J. Crosbie

Published in: BMC Clinical Pathology | Issue 1/2017

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Abstract

Background

Endometrial cancer (EC) is a major health concern due to its rising incidence. Whilst early stage disease is generally cured by surgery, advanced EC has a poor prognosis with limited treatment options. Altered energy metabolism is a hallmark of malignancy. Cancer cells drive tumour growth through aerobic glycolysis and must export lactate to maintain intracellular pH. The aim of this study was to evaluate the expression of the lactate/proton monocarboxylate transporters MCT1 and MCT4 and their chaperone CD147 in EC, with the ultimate aim of directing future drug development.

Methods

MCT1, MCT4 and CD147 expression was examined using immunohistochemical analysis in 90 endometrial tumours and correlated with clinico-pathological characteristics and survival outcomes.

Results

MCT1 and MCT4 expression was observed in the cytoplasm, the plasma membrane or both locations. CD147 was detected in the plasma membrane and associated with MCT1 (p = 0.003) but not with MCT4 (p = 0.207) expression. High MCT1 expression was associated with reduced overall survival (p = 0.029) and remained statistically significant after adjustment for survival covariates (p = 0.017).

Conclusion

Our data suggest that MCT1 expression is an important marker of poor prognosis in EC. MCT1 inhibition may have potential as a treatment for advanced or recurrent EC.
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Metadata
Title
Monocarboxylate Transporter 1 (MCT1) is an independent prognostic biomarker in endometrial cancer
Authors
Ayşe Latif
Amy L. Chadwick
Sarah J. Kitson
Hannah J. Gregson
Vanitha N. Sivalingam
James Bolton
Rhona J. McVey
Stephen A. Roberts
Kay M. Marshall
Kaye J. Williams
Ian J. Stratford
Emma J. Crosbie
Publication date
01-12-2017
Publisher
BioMed Central
Published in
BMC Clinical Pathology / Issue 1/2017
Electronic ISSN: 1472-6890
DOI
https://doi.org/10.1186/s12907-017-0067-7

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