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BMC Complementary Medicine and Therapies

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Open Access 01-12-2022 | Acupuncture | Research

Prevalence of late and long-term effects of cancer (treatment) and use of complementary and alternative medicine in Norway

Authors: Agnete E. Kristoffersen, Barbara Wider, Jorunn V. Nilsen, Mona Bjelland, Dana C. Mora, Johanna Hök Nordberg, Ann Ragnhild Broderstad, Kiwumulo Nakandi, Trine Stub

Published in: BMC Complementary Medicine and Therapies | Issue 1/2022

Abstract

Background

The increasing number of patients surviving cancer leads to more people experiencing late and long term-effects from the disease and its treatment. Fatigue, sleep disorders, early menopause, pain, and nerve damage are commonly reported. Methods helping people to recover after cancer treatment are therefore essential. The aims of this study were threefold; (1) to determine the level of cancer patients suffering from late and long-term effects of cancer diagnosis and treatment in Norway, (2) explore complementary and alternative medicine (CAM) modalities used for managing these adversities, and (3) describe self-perceived benefits and harms of the CAM interventions.

Methods

The study was conducted in cooperation with the Norwegian Cancer Society (NCS) and consisted of an online cross-sectional study among members of the NCS user panel with present or previous cancer (n = 706). The study was carried out in September/October 2021 using a modified cancer-specific version of the International Questionnaire to Measure Use of Complementary and Alternative Medicine (I-CAM-Q). A total of 315 women and 153 men agreed to participate, resulting in a response rate of 67%.

Results

Most of the participants (83%) suffered from late and long-term effects of cancer treatment; mostly fatigue (59.2%), sleep disorder (41.5%), hot flashes (39.2%), nerve damage (polyneuropathy, 38.0%), and pain (36.6%) with a mean number of 5.1 different late and long-term effects. Late and long-term effects were positively associated with younger age and college/university education. Nearly half of the participants experiencing late and long-term effects (43%) reported having used CAM to treat these complaints. Most frequently used were self-help practices (26%) such as relaxation therapy (19%), yoga (14%) and meditation (13%), but also visits to CAM providers were reported by 22%. Herbal- and other natural remedies to treat late and long-term effects were used by 13%. A high percentage of CAM users reported self-perceived improvements of their symptoms (86% for self-help practices, 90% for visits to CAM providers). Few experienced adverse effects of the CAM treatment.

Conclusion

A large proportion of cancer patients suffered from a wide range of late and long-term effects of cancer diagnosis and treatment, and they use CAM to treat these complaints to a rather high degree. Relaxation therapy, yoga, meditation, massage, and acupuncture were the most frequently used therapies regardless of complaint. The therapies used are generally considered to be both safe and beneficial for the respective complaint, indicating that the participants seem to be well informed about the choices they make.

Cancer in Norway 2021. Cancer incidence, mortality, survival and prevalence in Norway. Oslo: Cancer registry of Norway; 2022 [cited 2022 July 27]. Available from: https://www.kreftregisteret.no/globalassets/cancer-in-norway/2021/cin_report.pdf.

Key figures on cancer. Oslo: Cancer Registry of Norway; 2020 [cited 2022 June 29]. Available from: https://www.kreftregisteret.no/en/Temasider/key-figures-on-cancer/.

Chronic, late effects of cancer treatment: The consequences of a cure: Healio; 2020 [cited 2022 31. January]. Available from: https://www.healio.com/news/hematology-oncology/20200414/chronic-late-effects-of-cancer-treatment-the-consequences-of-a-cure.

Seneffekter etter kreftbehandling [late effects from cancer treatment] Oslo: Norwegian Directorate of Health; 2020. Available from: https://www.helsedirektoratet.no/rapporter/seneffekter-etter-kreftbehandling/Seneffekter%20etter%20kreftbehandling.pdf/_/attachment/inline/3d984c2a-7926-4d1a-a5f0-06d48fe7c95f:f3e498d059734ff34b013c1c206877e488e95600/Seneffekter%20etter%20kreftbehandling.pdf.

Helsedirektoratet. The Norwegian Directorate of Health: Nasjonalt handlingsprogram med retningslinjer for diagnostikk, behandling og oppfølging av kreft hos barn. Oslo: Helsedirektoratet. The Norwegian Directorate of Health; 2017.

Solem AG: "Ikke syk - Ikke frisk. (English: Neither ill - nor healthy." ). Plot, Dokumentar, Eksistens, dilemma. 2018;5(9):24–33.

Kirchhoff AC, Krull KR, Ness KK, Armstrong GT, Park ER, Stovall M, et al. Physical, mental, and neurocognitive status and employment outcomes in the childhood Cancer survivor study cohort. Cancer Epidemiol Biomark Prev. 2011;20(9):1838–49.CrossRef

Ness KK, Gurney JG, Zeltzer LK, Leisenring W, Mulrooney DA, Nathan PC, et al. The impact of limitations in physical, executive, and emotional function on health-related quality of life among adult survivors of childhood cancer: a report from the childhood Cancer survivor study. Arch Phys Med Rehabil. 2008;89(1):128–36.PubMedCrossRef

Ness KK, Hudson MM, Ginsberg JP, Nagarajan R, Kaste SC, Marina N, et al. Physical performance limitations in the childhood Cancer survivor study cohort. J Clin Oncol. 2009;27(14):2382–9.PubMedPubMedCentralCrossRef

10.

Reinertsen KV, Loge JH, Brekke M, Kiserud CE. Chronic fatigue in adult cancer survivors. Tidsskrift for Den norske legeforening. 2017;137(21). https://doi.org/10.4045/tidsskr.17.0040.

11.

Bissounauth V, Shatenstein B, Ghadirian P. Nutrition and breast cancer among sporadic cases and gene mutation carriers: an overview. Cancer Detect Prev. 2008;32:52–64.CrossRef

12.

Stein KD, Syrjala KL, Andrykowski MA. Physical and psychological long-term and late effects of cancer. Cancer. 2008;112:2577–92.PubMedCrossRef

13.

Bohn SH, Vandraas KF, Kiserud CE, Dahl AA, Thorsen L, Ewertz M, et al. Work status changes and associated factors in a nationwide sample of Norwegian long-term breast cancer survivors. J Cancer Surviv. 2022:1–10.

14.

Kiserud CE, Dahl AA, Fosså SD. Cancer survivorship in adults. In: Psycho-Oncology: Springer; 2018. p. 123–43.CrossRef

15.

Cancer in Norway 2020. Oslo: Cancer registry of Norway; 2021 [cited 2022 July 27]. Available from: https://healthtalkweb.s3.amazonaws.com/documents/Cancer_in_Norway_2020.pdf.

16.

Syse A, Tretli S, Kravdal Ø. Cancer’s impact on employment and earnings—a population-based study from Norway. J Cancer Surviv. 2008;2(3):149–58.PubMedCrossRef

17.

Dahl AA, Fosså SD, Lie HC, Loge JH, Reinertsen KV, Ruud E, et al. Employment status and work ability in long-term young adult Cancer survivors. J Adolesc Young Adult Oncol. 2019;8(3):304–11.PubMedCrossRef

18.

Johannesen TB, Langmark F, Wesenberg F, Lote K. Prevalence of Norwegian patients diagnosed with childhood cancer, their working ability and need of health insurance benefits. Acta Oncol. 2007;46(1):60–6.PubMedCrossRef

19.

Hansen F, Berntsen GR, Salamonsen A. Medical pluralism in the aftermath of cancer: health seeking actions and cancer patients’ shaping of trajectories to healing. Anthropol Med. 2020;27(3):330–46.PubMedCrossRef

20.

Saquib J, Madlensky L, Kealey S, Saquib N, Natarajan L, Newman VA, et al. Classification of CAM use and its correlates in patients with early-stage breast cancer. Integr Cancer Ther. 2011;10(2):138–47.PubMedCrossRef

21.

Act No. 64 of 27 June 2003 relating to the alternative treatment of disease, illness, etc. Oslo; 2003. Available from: https://app.uio.no/ub/ujur/oversatte-lover/data/lov-20030627-064-eng.pdf.

22.

Pinto AC, De Azambuja E. Improving quality of life after breast cancer: dealing with symptoms. Maturitas. 2011;70(4):343–8.PubMedCrossRef

23.

Bower JE. Cancer-related fatigue—mechanisms, risk factors, and treatments. Nat Rev Clin Oncol. 2014;11(10):597–609.PubMedPubMedCentralCrossRef

24.

Reinertsen KV, Engebraaten O, Loge JH, Cvancarova M, Naume B, Wist E, et al. Fatigue during and after breast cancer therapy—a prospective study. J Pain Symptom Manag. 2017;53(3):551–60.CrossRef

25.

JHv L, Abrahamsen AF, Ekeberg Ø, Kaasa S. Hodgkin's disease survivors more fatigued than the general population. J Clin Oncol. 1999;17(1):253.CrossRef

26.

Brem S, Kumar NB. Management of treatment-related symptoms in patients with breast cancer. Clin J Oncol Nurs. 2011;15(1):63–71.

27.

Ebede CC, Jang Y, Escalante CP. Cancer-related fatigue in cancer survivorship. Med Clin. 2017;101(6):1085–97.

28.

Fabi A, Bhargava R, Fatigoni S, Guglielmo M, Horneber M, Roila F, et al. Cancer-related fatigue: ESMO clinical practice guidelines for diagnosis and treatment. Ann Oncol. 2020;31(6):713–23.PubMedCrossRef

29.

Finnegan-John J, Molassiotis A, Richardson A, Ream E. A systematic review of complementary and alternative medicine interventions for the management of cancer-related fatigue. Integr Cancer Ther. 2013;12(4):276–90.PubMedCrossRef

30.

Mahon SM, Carr E. Sleep-wake disturbances: common side effect. Clin J Oncol Nurs. 2021;25(6):33.PubMedCrossRef

31.

Mai QD, Jacobs AW, Schieman S. Precarious sleep? Nonstandard work, gender, and sleep disturbance in 31 European countries. Soc Sci Med. 2019;237:112424.PubMedCrossRef

32.

Kirserud C, Dahl A, Fosså S. Seneffekter etter kreftbehandling. I E. In: Schilchting & E. Wist (red.), editor. Kreftsykdommer–en basisbok for helsepersonell; 2018. p. 148–61.

33.

Henneghan AM, Harrison T. Complementary and alternative medicine therapies as symptom management strategies for the late effects of breast cancer treatment. J Holist Nurs. 2015;33(1):84–97.PubMedCrossRef

34.

Szabo R, Marino J, Hickey M. Managing menopausal symptoms after cancer. Climacteric. 2019;22(6):572–8.PubMedCrossRef

35.

Eikeland SA, Smeland KB, Mols F, Fagerli UM, Bersvendsen HS, Kiserud CE, et al. Chemotherapy-induced peripheral neuropathy after modern treatment of Hodgkin's lymphoma; symptom burden and quality of life. Acta Oncol. 2021;60(7):911–20.PubMedCrossRef

36.

Seretny M, Currie GL, Sena ES, Ramnarine S, Grant R, MacLeod MR, et al. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. Pain®. 2014;155(12):2461–70.PubMedCrossRef

37.

Hess SL, Dahl AA, Kiserud CE. Seneffekter etter kreftbehandling [Late effects from cancer treatment]. Sykepleien. 2018:1–11.

38.

Swain SM, Arezzo JC. Neuropathy associated with microtubule inhibitors: diagnosis, incidence, and management. Clin Adv Hematol Oncol. 2008;6(6):455–67.PubMed

39.

Brami C, Bao T, Deng G. Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: a systematic review. Crit Rev Oncol Hematol. 2016;98:325–34.PubMedCrossRef

40.

Jordan B, Margulies A, Cardoso F, Cavaletti G, Haugnes H, Jahn P, et al. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO–EONS–EANO clinical practice guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020;31(10):1306–19.PubMedCrossRef

41.

Bao T, Seidman AD, Piulson L, Vertosick E, Chen X, Vickers AJ, et al. A phase IIA trial of acupuncture to reduce chemotherapy-induced peripheral neuropathy severity during neoadjuvant or adjuvant weekly paclitaxel chemotherapy in breast cancer patients. Eur J Cancer (Oxford, England : 1990). 2018;101:12–9.CrossRef

42.

GarciaMK CL, Guo Y, Zhou Y, You B, Chiang J, Orlowski RZ, et al. Electroacupuncture for thalidomide/bortezomib-induced peripheral neuropathy in multiple myeloma: a feasibility study. J Hematol Oncol. 2014;7:41.CrossRef

43.

Molassiotis A, Suen LKP, Cheng HL, Mok TSK, Lee SCY, Wang CH, et al. A randomized Assessor-blinded wait-list-controlled trial to assess the effectiveness of acupuncture in the management of chemotherapy-induced peripheral neuropathy. Integr Cancer Ther. 2019;18:1534735419836501.PubMedPubMedCentralCrossRef

44.

Han X, Wang L, Shi H, Zheng G, He J, Wu W, et al. Acupuncture combined with methylcobalamin for the treatment of chemotherapy-induced peripheral neuropathy in patients with multiple myeloma. BMC Cancer. 2017;17(1):40.PubMedPubMedCentralCrossRef

45.

Harrington CB, Hansen JA, Moskowitz M, Todd BL, Feuerstein M. It's not over when it's over: long-term symptoms in cancer survivors—a systematic review. Int J Psychiatry Med. 2010;40(2):163–81.PubMedCrossRef

46.

Breivik H, Cherny N, Collett B, De Conno F, Filbet M, Foubert A, et al. Cancer-related pain: a pan-European survey of prevalence, treatment, and patient attitudes. Ann Oncol. 2009;20(8):1420–33.PubMedCrossRef

47.

Fallon M, Giusti R, Aielli F, Hoskin P, Rolke R, Sharma M, et al. Management of cancer pain in adult patients: ESMO clinical practice guidelines. Ann Oncol. 2018;29:iv166–91.PubMedCrossRef

48.

Greco MT, Roberto A, Corli O, Deandrea S, Bandieri E, Cavuto S, et al. Quality of cancer pain management: an update of a systematic review of undertreatment of patients with cancer. J Clin Oncol. 2014;32(36):4149–54.PubMedCrossRef

49.

Maindet C, Burnod A, Minello C, George B, Allano G, Lemaire A. Strategies of complementary and integrative therapies in cancer-related pain—attaining exhaustive cancer pain management. Support Care Cancer. 2019;27(8):3119–32. https://doi.org/10.1007/s00520-019-04829-7.

50.

Bao Y, Kong X, Yang L, Liu R, Shi Z, Li W, et al. Complementary and alternative medicine for cancer pain: an overview of systematic reviews. Evid Based Complement Alternat Med. 2014;2014:170396. https://doi.org/10.1155/2014/170396.

51.

Hede K. Chemobrain is real but may need new name: Oxford University Press; 2008. p. 162–9.CrossRef

52.

Jansen CE, Miaskowski C, Dodd M, Dowling G. Chemotherapy-induced cognitive impairment in women with breast cancer: a critique of the literature. Oncol Nurs Forum. 2005;32(2):329–42. https://doi.org/10.1188/05.ONF.329-342.

53.

Gehring K, Roukema JA, Sitskoorn MM. Review of recent studies on interventions for cognitive deficits in patients with cancer. Expert Rev Anticancer Ther. 2012;12(2):255–69.PubMedCrossRef

54.

Zhang Z-J, Man S-C, Yam L-L, Yiu CY. Leung RC-Y, Qin Z-S, Chan K-WS, Lee VHF, Kwong a, Yeung W-F: Electroacupuncture trigeminal nerve stimulation plus body acupuncture for chemotherapy-induced cognitive impairment in breast cancer patients: an assessor-participant blinded, randomized controlled trial. Brain Behav Immun. 2020;88:88–96.PubMedCrossRef

55.

DiSipio T, Rye S, Newman B, Hayes S. Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. Lancet Oncol. 2013;14(6):500–15.PubMedCrossRef

56.

Hayes SC, Janda M, Ward LC, Reul-Hirche H, Steele ML, Carter J, et al. Lymphedema following gynecological cancer: results from a prospective, longitudinal cohort study on prevalence, incidence and risk factors. Gynecol Oncol. 2017;146(3):623–9.PubMedCrossRef

57.

Lindqvist E, Wedin M, Fredrikson M, Kjølhede P. Lymphedema after treatment for endometrial cancer− a review of prevalence and risk factors. Eur J Obstet Gynecol Reprod Biol. 2017;211:112–21.PubMedCrossRef

58.

Golshan M, Smith B. Prevention and management of arm lymphedema in the patient with breast cancer. J Support Oncol. 2006;4(8):381–6.PubMed

59.

Om lymfødem på grunn av kreftbehandling [About lymphedema due to cancer treatment]: Kreftlex; 2022 [cited 2022 May 6]. Available from: https://kreftlex.no/KSPROSEDYRERFASE1/OPPFOLGING/Lymfodem%20i%20arm%20ben/kreftlexFAQ?CancerType=Hud.

60.

Chao L-F, Zhang AL, Liu H-E, Cheng M-H, Lam H-B, Lo SK. The efficacy of acupoint stimulation for the management of therapy-related adverse events in patients with breast cancer: a systematic review. Breast Cancer Res Treat. 2009;118(2):255–67.PubMedCrossRef

61.

Kanakura Y, Niwa K, Kometani K, Nakazawa K, Yamaguchi Y, Ishikawa H, et al. Effectiveness of acupuncture and moxibustion treatment for lymphedema following intrapelvic lymph node dissection: a preliminary report. Am J Chin Med. 2002;30(01):37–43.PubMedCrossRef

62.

Jacobson JS, Workman SB, Kronenberg F. Research on complementary/alternative medicine for patients with breast cancer: a review of the biomedical literature. J Clin Oncol. 2000;18(3):668–83.PubMedCrossRef

63.

Ryan TJ, Narahari SR. Reporting an alliance using an integrative approach to the management of lymphedema in India. Int J Low Extrem Wounds. 2012;11(1):5–9.PubMedCrossRef

64.

Ota KS. Postmastectomy lymphedema: a call for osteopathic medical research. J Osteopath Med. 2006;106(3):110–1.

65.

Bao T, Iris Zhi W, Vertosick EA, Li QS, DeRito J, Vickers A, et al. Acupuncture for breast cancer-related lymphedema: a randomized controlled trial. Breast Cancer Res Treat. 2018;170(1):77–87.PubMedPubMedCentralCrossRef

66.

Cassileth BR, Van Zee KJ, Yeung KS, Coleton MI, Cohen S, Chan YH, et al. Acupuncture in the treatment of upper-limb lymphedema: results of a pilot study. Cancer. 2013;119(13):2455–61.PubMedCrossRef

67.

Herpertz U. Erysipelas and lymphedema. Fortschr Med. 1998;116(12):36–40.PubMed

68.

Masmoudi A, Maaloul I, Turki H, Elloumi Y, Marrekchi S, Bouassida S, et al. Erysipelas after breast cancer treatment (26 cases). Dermatol Online J. 2005;11(3):12.

69.

Soo J, Bicanic T, Heenan S, Mortimer P. Lymphatic abnormalities demonstrated by lymphoscintigraphy after lower limb cellulitis. Br J Dermatol. 2008;158(6):1350–3.PubMedCrossRef

70.

Mitchell AJ, Ferguson DW, Gill J, Paul J, Symonds P. Depression and anxiety in long-term cancer survivors compared with spouses and healthy controls: a systematic review and meta-analysis. Lancet Oncol. 2013;14(8):721–32.PubMedCrossRef

71.

Mykletun AKA, Mathiesen KS. Psykiske lidelser i Norge: Et folkehelseperspektiv. Nasjonalt Folkehelseinstitutt. In: Rapport 2009:8 (Mental disorders in Norway: A public health perspective. Norwegian Institute of Public Health. Report 2009:8); 2009.

72.

Pitman A, Suleman S, Hyde N, Hodgkiss A. Depression and anxiety in patients with cancer. BMJ. 2018;361:k1415. https://doi.org/10.1136/bmj.k1415.

73.

D'Silva S, Poscablo C, Habousha R, Kogan M, Kligler B. Mind-body medicine therapies for a range of depression severity: a systematic review. Psychosomatics. 2012;53(5):407–23.PubMedCrossRef

74.

Ando M, Morita T, Akechi T, Ito S, Tanaka M, Ifuku Y, et al. The efficacy of mindfulness-based meditation therapy on anxiety, depression, and spirituality in Japanese patients with cancer. J Palliat Med. 2009;12(12):1091–4.PubMedCrossRef

75.

Kim YH, Kim HJ, Do Ahn S, Seo YJ, Kim SH. Effects of meditation on anxiety, depression, fatigue, and quality of life of women undergoing radiation therapy for breast cancer. Complement Ther Med. 2013;21(4):379–87.PubMedCrossRef

76.

Lee M, Lee E, Ernst E. Massage therapy for breast cancer patients: a systematic review. Ann Oncol. 2011;22(6):1459–61.PubMedCrossRef

77.

Å leve med og etter kreft. En undersøkelse blant kreftpasienter og pårørende i Kreftforeningens brukerpanel. [Living with and after cancer. A survey among cancer patients and relatives in the Cancer Society's user panel] Oslo: The Norwegian Cancer Socienty; 2018 [cited 2022 April 7]. Available from: https://kreftforeningen.no/content/uploads/2019/04/Rehabiliteringsrapporten-2018_web.pdf.

78.

Quandt SA, Verhoef MJ, Arcury TA, Lewith GT, Steinsbekk A, Kristoffersen AE, et al. Development of an international questionnaire to measure use of complementary and alternative medicine (I-CAM-Q). J Altern Complement Med. 2009;15(4):331–9.PubMedPubMedCentralCrossRef

79.

Kristoffersen AE, Nilsen JV, Stub T, Nordberg JH, Wider B, Mora D, et al. Use of complementary and alternative medicine in the context of cancer; prevalence, reasons for use, disclosure, information received, risks and benefits reported by people with cancer in Norway. BMC Complement Med Ther. 2022;22(1):1–21.CrossRef

80.

Taherdoost H: Determining sample size; how to calculate survey sample size. International Journal of Economics and Management Systems 2017. ffhal-02557333f.CrossRef

81.

White A, Boon H, Alraek T, Lewith G, Liu J-P, Norheim A-J, et al. Reducing the risk of complementary and alternative medicine (CAM): challenges and priorities. Eur J Integr Med. 2014;6(4):404–8.CrossRef

82.

Cramer H, Quinker D, Schumann D, Wardle J, Dobos G, Lauche R. Adverse effects of yoga: a national cross-sectional survey. BMC Complement Altern Med. 2019;19(1):1–10.CrossRef

83.

Goldberg SB, Lam SU, Britton WB, Davidson RJ. Prevalence of meditation-related adverse effects in a population-based sample in the United States. Psychother Res. 2021;32(3):291–305. https://doi.org/10.1080/10503307.2021.1933646.

84.

Cambron JA, Dexheimer J, Coe P, Swenson R. Side-effects of massage therapy: a cross-sectional study of 100 clients. J Altern Complement Med. 2007;13(8):793–6.PubMedCrossRef

85.

Melchart D, Weidenhammer W, Streng A, Reitmayr S, Hoppe A, Ernst E, et al. Prospective investigation of adverse effects of acupuncture in 97 733 patients. Arch Intern Med. 2004;164(1):104–5.PubMedCrossRef

86.

Relaxation Techniques: What You Need To Know Maryland, USA: National Center for Complementary and Integrative Health; 2022 [cited 2022 April 13]. Available from: https://www.nccih.nih.gov/health/relaxation-techniques-what-you-need-to-know#:~:text=Relaxation%20techniques%20are%20generally%20considered,or%20fear%20of%20losing%20control.

87.

Mellblom AV, Kiserud CE, Rueegg CS, Ruud E, Loge JH, Fossa SD, et al. Self-reported late effects and long-term follow-up care among 1889 long-term Norwegian childhood, adolescent, and young adult Cancer survivors (the NOR-CAYACS study). Support Care Cancer. 2021;29(6):2947–57.PubMedCrossRef

88.

Klonoff-Cohen H, Polavarapu M. Existence of late-effects instruments for cancer survivors: a systematic review. PLoS One. 2020;15(2):e0229222.PubMedPubMedCentralCrossRef

89.

Eustachi A, Pajtler H, Linde K, Melchart D, Weidenhammer W. Patients of an interdisciplinary cancer treatment center: use of, knowledge about, and demand for CAM treatment options. Integr Cancer Ther. 2009;8(1):56–62.PubMedCrossRef

90.

Salleh SNSM, Farooqui M, Gnanasan S, Karuppannan M. Use of complementary and alternative medicines (CAM) among Malaysian cancer patients for the management of chemotherapy related side effects (CRSE). J Complement Integr Med. 2021;18(4):805–12.

91.

Keene MR, Heslop IM, Sabesan SS, Glass BD. Complementary and alternative medicine use in cancer: a systematic review. Complement Ther Clin Pract. 2019;35:33–47.PubMedCrossRef

92.

Davis SR, Lijovic M, Fradkin P, Bradbury J, La China M, Schwarz M, et al. Use of complementary and alternative therapy by women in the first 2 years after diagnosis and treatment of invasive breast cancer. Menopause. 2010;17(5):1004–9.PubMedCrossRef

93.

Nakandi KS, Mora D, Stub T, Kristoffersen AE. Conventional health care service utilization among cancer survivors that visit traditional and complementary providers in the Tromsø study: a cross-sectional study. BMC Health Serv Res. 2022;22(53). https://doi.org/10.1186/s12913-021-07445-6.

94.

Jaradat NA, Shawahna R, Eid AM, Al-Ramahi R, Asma MK, Zaid AN. Herbal remedies use by breast cancer patients in the West Bank of Palestine. J Ethnopharmacol. 2016;178:1–8.PubMedCrossRef

95.

Abuelgasim KA, Alsharhan Y, Alenzi T, Alhazzani A, Ali YZ, Jazieh AR. The use of complementary and alternative medicine by patients with cancer: a cross-sectional survey in Saudi Arabia. BMC Complement Altern Med. 2018;18(1):1–8.CrossRef

96.

Al-Naggar RA, Bobryshev YV, Abdulghani M, Rammohan S, Osman MT, Kadir SYA. Complementary/alternative medicine use among cancer patients in Malaysia. World J Med Sci. 2013;8(2):157–64.

97.

Rosenberg EI, Genao I, Chen I, Mechaber AJ, Wood JA, Faselis CJ, et al. Complementary and alternative medicine use by primary care patients with chronic pain. Pain Med. 2008;9(8):1065–72.PubMedCrossRef

98.

S3-Leitlinie Komplementärmedizin in der Behandlung von onkologischen PatientInnen Berlin, Germany 2021 [cited 2022 March 17]. Available from: https://www.leitlinienprogramm-onkologie.de/leitlinien/komplementaermedizin/.

99.

Lyman GH, Greenlee H, Bohlke K, Bao T, DeMichele AM, Deng GE, et al. Integrative therapies during and after breast cancer treatment: ASCO endorsement of the SIO clinical practice guideline. J Clin Oncol. 2018;36(25):2647–55.PubMedCrossRef

100.

CAM Cancer. Complementary and Alternative medicine for Cancer Tromsø: NAFKAM; [cited 2022 May 5]. Available from: http://cam-cancer.org/en.

101.

Reinertsen KV, Cvancarova M, Loge JH, Edvardsen H, Wist E, Fossa SD. Predictors and course of chronic fatigue in long-term breast cancer survivors. J Cancer Surviv. 2010;4(4):405–14.PubMedPubMedCentralCrossRef

102.

Seland M, Holte H, Bjoro T, Schreiner T, Bollerslev J, Loge JH, et al. Chronic fatigue is prevalent and associated with hormonal dysfunction in long-term non-Hodgkin lymphoma survivors treated with radiotherapy to the head and neck region. Leuk Lymphoma. 2015;56(12):3306–14.PubMedCrossRef

103.

Vistad I, Fossa SD, Kristensen GB, Dahl AA. Chronic fatigue and its correlates in long-term survivors of cervical cancer treated with radiotherapy. BJOG. 2007;114(9):1150–8.PubMedCrossRef

104.

Pearson NJ, Johnson LL, Nahin RL. Insomnia, trouble sleeping, and complementary and alternative medicine: analysis of the 2002 national health interview survey data. Arch Intern Med. 2006;166(16):1775–82.PubMedCrossRef

105.

Cheuk DK, Yeung WF, Chung K, Wong V. Acupuncture for insomnia. Cochrane Database Syst Rev. 2012;9:CD005472.

106.

Greenlee H, DuPont-Reyes MJ, Balneaves LG, Carlson LE, Cohen MR, Deng G, et al. Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA Cancer J Clin. 2017;67(3):194–232.PubMedPubMedCentralCrossRef

107.

Samuel SR, Gururaj R, Kumar KV, Vira P, Saxena P, Keogh JWL. Randomized control trial evidence for the benefits of massage and relaxation therapy on sleep in cancer survivors—a systematic review. J Cancer Surviv. 2021;15(5):799–810.PubMedCrossRef

108.

Davidson JR, MacLean AW, Brundage MD, Schulze K. Sleep disturbance in cancer patients. Soc Sci Med. 2002;54(9):1309–21.PubMedCrossRef

109.

Savard J, Morin CM. Insomnia in the context of cancer: a review of a neglected problem. J Clin Oncol. 2001;19(3):895–908.PubMedCrossRef

110.

Pilkington K, Ernst E. Acupuncture for hot flushes. Tromsø: NAFKAM; 2021 [cited 2022 May 5]. Available from: https://cam-cancer.org/en/acupuncture-hot-flushes.

111.

Carpenter JS, Andrykowski MA, Cordova M, Cunningham L, Studts J, McGrath P, et al. Hot flashes in postmenopausal women treated for breast carcinoma: prevalence, severity, correlates, management, and relation to quality of life. Cancer. 1998;82(9):1682–91.PubMedCrossRef

112.

Su HI, Sammel MD, Springer E, Freeman EW, DeMichele A, Mao JJ. Weight gain is associated with increased risk of hot flashes in breast cancer survivors on aromatase inhibitors. Breast Cancer Res Treat. 2010;124(1):205–11.PubMedPubMedCentralCrossRef

113.

Paice JA, Portenoy R, Lacchetti C, Campbell T, Cheville A, Citron M, et al. Management of chronic pain in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Clin Oncol. 2016;34(27):3325–45.

114.

Pilkington K. Acupuncture in cancer pain. Tromsø: NAFKAM; 2021 [cited 2022 May 5]. Available from: https://cam-cancer.org/en/acupuncture-cancer-pain.

115.

Boland EG, Ahmedzai SH. Persistent pain in cancer survivors. Curr Opin Support Palliat Care. 2017;11(3):181–90.PubMedCrossRef

116.

Paice JA. Chronic treatment-related pain in cancer survivors. Pain. 2011;152(3):S84–9.PubMedCrossRef

117.

Kristoffersen AE, Stub T, Broderstad AR, Hansen AH. Use of traditional and complementary medicine among Norwegian cancer patients in the seventh survey of the Tromso study. BMC Complement Altern Med. 2019;19(1):341.PubMedPubMedCentralCrossRef

118.

The world medical association (WMA). Declaration of Helsinki - ethical principles for medical research involving human subjects 1964. Ferney-Voltaire: The World Medical Association; 2013.

119.

Examples of activities that do not require approval from REC etikkom.no: REK Regional Committees for medical and health reseach ethics; 2012. Available from: https://helseforskning.etikkom.no/reglerogrutiner/soknadsplikt/sokerikkerek?p_dim=34999&_ikbLanguageCode=us.

120.

Lov om helseregistre og behandling av helseopplysninger (helseregisterloven) [The Health Registry Act] lovdata.no2014. Available from: https://lovdata.no/dokument/NL/lov/2014-06-20-43#KAPITTEL_2.

Title: Prevalence of late and long-term effects of cancer (treatment) and use of complementary and alternative medicine in Norway
Authors: Agnete E. Kristoffersen
Barbara Wider
Jorunn V. Nilsen
Mona Bjelland
Dana C. Mora
Johanna Hök Nordberg
Ann Ragnhild Broderstad
Kiwumulo Nakandi
Trine Stub
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Acupuncture
Massage
Published in: BMC Complementary Medicine and Therapies / Issue 1/2022
Electronic ISSN: 2662-7671
DOI: https://doi.org/10.1186/s12906-022-03790-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Prevalence of late and long-term effects of cancer (treatment) and use of complementary and alternative medicine in Norway

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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