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BMC Oral Health
Published in: BMC Oral Health 1/2023

Open Access 01-12-2023 | Gingival Diseases | Research

The association between periodontal diseases and helicobacter pylori: an updated meta-analysis of observational studies

Authors: Yousef Moradi, Lobat Majidi, Sorour Khateri, Nima Azh, Reza Ghanei Gheshlagh, Nadia Saniee, Mostafa Zarei, Farhad Moradpour

Published in: BMC Oral Health | Issue 1/2023

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Abstract

Introduction

Various studies have examined the association between periodontitis and helicobacter pylori and reported conflicting results. The aimed of this systematic review and meta-analysis estimating the association between these two variables.

Methods

Electronic databases including PubMed (Medline), Scopus, Web of Sciences and Medline (Elsevier) were searched using the relevant keywords. All observational studies comparing the association between periodontitis and helicobacter pylori were considered. The Newcastle - Ottawa Quality Assessment Scale (NOS) checklist was used for assessing quality of included studies. All statistical analyses were completed using STATA (Version 16).

Results

Twenty-three studies with 8,638 patients (15 case-control with 2,366 patients and 8 cross-sectional with 6,272 patients) were included in this meta-analysis. After combining the selected studies, the odds of presence the Helicobacter pylori infection in patients with the periodontal disease was 2.47 (OR: 2.47; 95% CI: 2.01, 3.03; I2: 50.87%; P: 0.001). Also, the odds after combining case-control studies was 2.77 (OR: 2.77; % 95 CI: 2.11, 3.66; I2: 37.16%; P: 0.049) and after combining cross-sectional analytical ones, it was equal to 2.07 (OR: 2.07; 95% CI: 1.62, 2.65; I2: 43.25%; P: 0.050).

Conclusion

Based on the results of this meta-analysis, the association between Helicobacter pylori infection and the periodontal disease is evident.
Appendix
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Metadata
Title
The association between periodontal diseases and helicobacter pylori: an updated meta-analysis of observational studies
Authors
Yousef Moradi
Lobat Majidi
Sorour Khateri
Nima Azh
Reza Ghanei Gheshlagh
Nadia Saniee
Mostafa Zarei
Farhad Moradpour
Publication date
01-12-2023
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2023
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-023-03232-3

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