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BMC Oral Health
Published in: BMC Oral Health 1/2021

Open Access 01-12-2021 | Coronary Heart Disease | Research

Risk of coronary heart disease in patients with periodontitis among the middled-aged and elderly in China: a cohort study

Authors: Kaikai Gao, Zhiyuan Wu, Yue Liu, Lixin Tao, Yanxia Luo, Xinghua Yang, Jingbo Zhang, Xiuhua Guo, Songlin Wang

Published in: BMC Oral Health | Issue 1/2021

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Abstract

Background

Convincing evidence of the periodontitis as a risk factor for coronary heart disease (CHD) is lacking due to shared risk factors, and no cohort study has investigated the association between CHD and periodontitis in Chinese populations.

Methods

This study used a prospective cohort study design. The analysis included 4591 participants aged 40 years and older (3146 men and 1445 women). The association between CHD and periodontitis was estimated using relative risk (RR) calculated using modified Poisson regression. Multiple mediation analysis was used to differentiate the relative effects (RE) from different risk factors on the effect of periodontitis on CHD.

Results

In the analysis using the imputed dataset and fully adjusted model, participants with periodontitis at baseline had 37% increased risk of CHD overall compared to those without periodontitis at baseline (RR 1.37; 95% CI 0.96–1.95). Most of the association can be explained by age, sex, history of diabetes, history of hypertension, uric acid and education (RE 0.76; 95% CI 0.41–1.02).

Conclusion

Periodontitis was weakly associated with an increased risk of CHD among the middled-aged and elderly in China. Further studies are required to identify more mediators and elucidate the mechanisms of how periodontitis increases the risk of CHD.
Appendix
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Metadata
Title
Risk of coronary heart disease in patients with periodontitis among the middled-aged and elderly in China: a cohort study
Authors
Kaikai Gao
Zhiyuan Wu
Yue Liu
Lixin Tao
Yanxia Luo
Xinghua Yang
Jingbo Zhang
Xiuhua Guo
Songlin Wang
Publication date
01-12-2021
Publisher
BioMed Central
Published in
BMC Oral Health / Issue 1/2021
Electronic ISSN: 1472-6831
DOI
https://doi.org/10.1186/s12903-021-01951-z

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