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BMC Oral Health

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Open Access 01-12-2016 | Research article

Perceptions of medical doctors on bisphosphonate-related osteonecrosis of the jaw

Authors: Jin-Woo Kim, Su-Ra Jeong, Sun-Jong Kim, YeonSoo Kim

Published in: BMC Oral Health | Issue 1/2016

Abstract

Background

This study aimed to investigate medical doctors’ awareness of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and the status of dental referrals.

Methods

Self-administered questionnaires were distributed to medical doctors practicing internal medicine, family medicine, and orthopedics at the 6 tertiary medical centers located in Seoul, Korea. The survey consisted of 22 questions regarding the general characteristics, bisphosphonate therapy, awareness of BRONJ, and implementation of dental referrals.

Results

Among 192 medical doctors, 21.9 % had not heard of the disease. Only 8.9 % correctly answered all 5 questions testing BRONJ knowledge. Dental referrals made by medical doctors were implemented in less than 30 % of the total patients. Oncology specialists most often recognized the necessity of dental referrals followed in decreasing order by endocrinology, rheumatology, family medicine, and orthopedic specialists.

Conclusion

Given medical doctors’ low BRONJ perception and implementation level of dental referrals, enhancing information dissemination on BRONJ and development of a highly accessible educational program recognizing the need for dental referrals are urgent.

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Allen MR, Burr DB. Bisphosphonate effects on bone turnover, microdamage, and mechanical properties: what we think we know and what we know that we don’t know. Bone. 2011;49:56–65.CrossRefPubMed

Chan AS. Ten years of alendronate treatment for osteoporosis in postmenopausal women. N Engl J Med. 2004;351:190–2.CrossRefPubMed

Russell RG, Watts NB, Ebetino FH, Rogers MJ. Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy. Osteoporos Int. 2008;19:733–59.CrossRefPubMed

Marx RE. Pamidronate (Aredia) and zoledronate (Zometa) induced avascular necrosis of the jaws: a growing epidemic. J Oral Maxillofac Surg. 2003;61:1115–7.CrossRefPubMed

Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteonecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004;62:527–34.CrossRefPubMed

Armamento-Villareal R, Napoli N, Panwar V, Novack D. Suppressed bone turnover during alendronate therapy for high-turnover osteoporosis. N Engl J Med. 2006;355:2048–50.CrossRefPubMed

Ruggiero SL, Dodson TB, Fantasia J, Goodday R, Aghaloo T, Mehrotra B, O’Ryan F. American Association of Oral and Maxillofacial Surgeons position paper on medication-related osteonecrosis of the jaw--2014 update. J Oral Maxillofac Surg. 2014;72:1938–56.CrossRefPubMed

Cremers S, Farooki A. Biochemical markers of bone turnover in osteonecrosis of the jaw in patients with osteoporosis and advanced cancer involving the bone. Ann N Y Acad Sci. 2011;1218:80–7.CrossRefPubMed

Ruggiero SL, Dodson TB, Assael LA, Landesberg R, Marx RE, Mehrotra B. American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws--2009 update. J Oral Maxillofac Surg. 2009;67:2–12.CrossRefPubMed

10.

Lee JK, Kim K-W, Choi J-Y, Moon S-Y, Kim S-G, Kim C-H, Kim H-M, Kwon Y-D, Kim Y-D, Lee D-K, et al. Bisphosphonates-related osteonecrosis of the jaw in Korea: a preliminary report. J Korean Assoc Oral Maxillofac Surg. 2013;39:9–13.CrossRefPubMedPubMedCentral

11.

Khosla S, Burr D, Cauley J, Dempster DW, Ebeling PR, Felsenberg D, Gagel RF, Gilsanz V, Guise T, Koka S, et al. Bisphosphonate-associated osteonecrosis of the jaw: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007;22:1479–91.CrossRefPubMed

12.

Yong-Duck P, Young-Ran K, Deog-Yoon K, Yoon-Sok C, Jeung-Keun L, Yeo-Gab K, Yong-Dae K. Awareness of Korean dentists on bisphosphonate related osteonecrosis of the jaws: preliminary report. J Korean Assoc Oral Maxillofac Surg. 2009;35:153–7.

13.

Gyeon-Yeon Kang. A survey on the cognizance and perceptions of BRONJ among the dental hygienists in Seoul. Master thesis, Ewha Womans University, Graduate School of Clinical Dentistry; 2014.

14.

Khan AA, Morrison A, Hanley DA, Felsenberg D, McCauley LK, O’Ryan F, Reid IR, Ruggiero SL, Taguchi A, Tetradis S, et al. Diagnosis and management of osteonecrosis of the jaw: a systematic review and international consensus. J Bone Miner Res. 2015;30:3–23.CrossRefPubMed

15.

Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods. 2007;39:175–91.CrossRefPubMed

16.

Reid IR, Cornish J. Epidemiology and pathogenesis of osteonecrosis of the jaw. Nat Rev Rheumatol. 2012;8:90–6.

17.

Lam DK, Sandor GK, Holmes HI, Evans AW, Clokie CM. A review of bisphosphonate-associated osteonecrosis of the jaws and its management. J Can Dent Assoc. 2007;73:417–22.PubMed

Title: Perceptions of medical doctors on bisphosphonate-related osteonecrosis of the jaw
Authors: Jin-Woo Kim
Su-Ra Jeong
Sun-Jong Kim
YeonSoo Kim
Publication date: 01-12-2016
Publisher: BioMed Central
Published in: BMC Oral Health / Issue 1/2016
Electronic ISSN: 1472-6831
DOI: https://doi.org/10.1186/s12903-016-0290-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Perceptions of medical doctors on bisphosphonate-related osteonecrosis of the jaw

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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