Skip to main content
Top
Published in: BMC Musculoskeletal Disorders 1/2022

Open Access 01-12-2022 | Osteoarthrosis | Research article

Knee varus alters three-dimensional ankle alignment in standing- a study with upright computed tomography

Authors: Satoshi Hakukawa, Kazuya Kaneda, Satoshi Oki, Kengo Harato, Yoshitake Yamada, Yasuo Niki, Takeo Nagura, Masaya Nakamura, Masahiro Jinzaki

Published in: BMC Musculoskeletal Disorders | Issue 1/2022

Login to get access

Abstract

Background

For knee osteoarthritis (OA) treatment, it is important to correct the lower limb alignment including the foot. However, in the upright position, lower limb alignment is generally assessed from the body surface or radiographs, and it is a challenge to capture the exact characteristics of three-dimensional lower limb alignment. The purpose of the study was to measure lower limb alignment in patients with knee OA using upright computed tomography (CT) and radiography, and to identify features of knee joint deformity.

Methods

A total of 45 limbs in 25 patients with knee OA were enrolled. The subjects underwent both upright CT and radiography for the whole lower limb in the standing position. The joint angles were calculated on both images. The degree of knee OA was classified according to Kellgren-Lawrence (KL) grade by referring to radiography, which is mainly based on the degree of articular cartilage loss and severity of osteophytes, and the characteristics or correlation between knee and ankle joint in each group was investigated.

Results

In KL-I, there was an association between varus of the knee joint and internal rotation of the talocrural joint (r = 0.76, P < 0.05). In KL-II, there was an association between varus of the knee joint and eversion of the subtalar joint (r = 0.63, P < 0.05) and talocrural joint (r = − 0.65, P < 0.05). In KL-III, there was an association between varus of the knee joint and internal rotation of the subtalar joint (r = − 0.62, P < 0.05), and in KL-IV, there was an association between varus of the knee joint and internal rotation of the subtalar joint (r = − 0.58, P < 0.05).

Conclusions

The lower limb alignment of patients with knee OA in the standing position was found that as knee OA worsened, it became apparent that compensatory knee joint alignment depended on the ankle joint rather than the subtalar joint. The results may help in the rehabilitation of patients with knee OA, since the ankle joint alignment has a significant impact on the knee joint during coarse movements involving load.
Literature
1.
go back to reference Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–30.CrossRef Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, et al. The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis. 2014;73(7):1323–30.CrossRef
2.
go back to reference Driban JB, Stout AC, Duryea J, Lo GH, Harvey WF, Price LL, Ward RJ, Eaton CB, Barbe MF, Lu B, et al. Coronal tibial slope is associated with accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. BMC Musculoskelet Disord. 2016;17(1):299-305. Driban JB, Stout AC, Duryea J, Lo GH, Harvey WF, Price LL, Ward RJ, Eaton CB, Barbe MF, Lu B, et al. Coronal tibial slope is associated with accelerated knee osteoarthritis: data from the Osteoarthritis Initiative. BMC Musculoskelet Disord. 2016;17(1):299-305.
3.
go back to reference Andriacchi TP, Favre J, Erhart-Hledik JC, Chu CR. A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease. Ann Biomed Eng. 2015;43(2):376–87.CrossRef Andriacchi TP, Favre J, Erhart-Hledik JC, Chu CR. A systems view of risk factors for knee osteoarthritis reveals insights into the pathogenesis of the disease. Ann Biomed Eng. 2015;43(2):376–87.CrossRef
4.
go back to reference Norton AA, Callaghan JJ, Amendola A, Phisitkul P, Wongsak S, Liu SS, et al. Correlation of knee and Hindfoot deformities in advanced knee OA: compensatory Hindfoot alignment and where it occurs. Clin Orthop Relat Res. 2015;473(1):166–74.CrossRef Norton AA, Callaghan JJ, Amendola A, Phisitkul P, Wongsak S, Liu SS, et al. Correlation of knee and Hindfoot deformities in advanced knee OA: compensatory Hindfoot alignment and where it occurs. Clin Orthop Relat Res. 2015;473(1):166–74.CrossRef
5.
go back to reference Kimura T, Kubota M, Taguchi T, Suzuki N, Hattori A, Marumo K. Evaluation of first-ray mobility in patients with hallux Valgus using weight-bearing CT and a 3-D analysis system. J Bone Joint Surg. 2017;99(3):247–55.CrossRef Kimura T, Kubota M, Taguchi T, Suzuki N, Hattori A, Marumo K. Evaluation of first-ray mobility in patients with hallux Valgus using weight-bearing CT and a 3-D analysis system. J Bone Joint Surg. 2017;99(3):247–55.CrossRef
6.
go back to reference Burssens ABM, Buedts K, Barg A, Vluggen E, Demey P, Saltzman CL, et al. Is lower-limb alignment associated with Hindfoot deformity in the coronal plane? A Weightbearing CT analysis. Clin Orthop Relat Res. 2020;478(1):154–68.CrossRef Burssens ABM, Buedts K, Barg A, Vluggen E, Demey P, Saltzman CL, et al. Is lower-limb alignment associated with Hindfoot deformity in the coronal plane? A Weightbearing CT analysis. Clin Orthop Relat Res. 2020;478(1):154–68.CrossRef
7.
go back to reference Collan L, Kankare JA, Mattila K. The biomechanics of the first metatarsal bone in hallux valgus: a preliminary study utilizing a weight bearing extremity CT. Foot Ankle Surg. 2013;19(3):155–61.CrossRef Collan L, Kankare JA, Mattila K. The biomechanics of the first metatarsal bone in hallux valgus: a preliminary study utilizing a weight bearing extremity CT. Foot Ankle Surg. 2013;19(3):155–61.CrossRef
8.
go back to reference Carrino JA, Al Muhit A, Zbijewski W, Thawait GK, Stayman JW, Packard N, et al. Dedicated cone-beam CT system for extremity imaging. Radiology. 2014;270(3):816–24.CrossRef Carrino JA, Al Muhit A, Zbijewski W, Thawait GK, Stayman JW, Packard N, et al. Dedicated cone-beam CT system for extremity imaging. Radiology. 2014;270(3):816–24.CrossRef
9.
go back to reference Toda Y, Tsukimura N. A 2-year follow-up of a study to compare the efficacy of lateral wedged insoles with subtalar strapping and in-shoe lateral wedged insoles in patients with varus deformity osteoarthritis of the knee. Osteoarthr Cartil. 2006;14(3):231–7.CrossRef Toda Y, Tsukimura N. A 2-year follow-up of a study to compare the efficacy of lateral wedged insoles with subtalar strapping and in-shoe lateral wedged insoles in patients with varus deformity osteoarthritis of the knee. Osteoarthr Cartil. 2006;14(3):231–7.CrossRef
10.
go back to reference Toda Y, Tsukimura N, Segal N. An optimal duration of daily wear for an insole with subtalar strapping in patients with varus deformity osteoarthritis of the knee. Osteoarthr Cartil. 2005;13(4):353–60.CrossRef Toda Y, Tsukimura N, Segal N. An optimal duration of daily wear for an insole with subtalar strapping in patients with varus deformity osteoarthritis of the knee. Osteoarthr Cartil. 2005;13(4):353–60.CrossRef
11.
go back to reference Kuroyanagi Y, Nagura T, Matsumoto H, Otani T, Suda Y, Nakamura T, et al. The lateral wedged insole with subtalar strapping significantly reduces dynamic knee load in the medial compartment. Osteoarthr Cartil. 2007;15(8):932–6.CrossRef Kuroyanagi Y, Nagura T, Matsumoto H, Otani T, Suda Y, Nakamura T, et al. The lateral wedged insole with subtalar strapping significantly reduces dynamic knee load in the medial compartment. Osteoarthr Cartil. 2007;15(8):932–6.CrossRef
12.
go back to reference Ferreira V, Simões R, Gonçalves RS, Machado L, Roriz P. The optimal degree of lateral wedge insoles for reducing knee joint load: a systematic review and meta-analysis. Arch Physiother. 2019;9(1):18-29. Ferreira V, Simões R, Gonçalves RS, Machado L, Roriz P. The optimal degree of lateral wedge insoles for reducing knee joint load: a systematic review and meta-analysis. Arch Physiother. 2019;9(1):18-29.
13.
go back to reference Akasaki Y, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Horikawa T, et al. Patient-specific prediction of joint line convergence angle after high tibial osteotomy using a whole-leg radiograph standing on lateral-wedge insole. Knee Surg Sports Traumatol Arthrosc. 2020;28(10):3200–6.CrossRef Akasaki Y, Mizu-Uchi H, Hamai S, Tsushima H, Kawahara S, Horikawa T, et al. Patient-specific prediction of joint line convergence angle after high tibial osteotomy using a whole-leg radiograph standing on lateral-wedge insole. Knee Surg Sports Traumatol Arthrosc. 2020;28(10):3200–6.CrossRef
14.
go back to reference Weidow J, Tranberg R, Saari T, Kärrholm J. Hip and knee joint rotations differ between patients with medial and lateral knee osteoarthritis: gait analysis of 30 patients and 15 controls. J Orthop Res. 2006;24(9):1890–9.CrossRef Weidow J, Tranberg R, Saari T, Kärrholm J. Hip and knee joint rotations differ between patients with medial and lateral knee osteoarthritis: gait analysis of 30 patients and 15 controls. J Orthop Res. 2006;24(9):1890–9.CrossRef
15.
go back to reference Jinzaki M, Yamada Y, Nagura T, Nakahara T, Yokoyama Y, Narita K, et al. Development of upright computed tomography with area detector for whole-body scans. Investig Radiol. 2020;55(2):73–83.CrossRef Jinzaki M, Yamada Y, Nagura T, Nakahara T, Yokoyama Y, Narita K, et al. Development of upright computed tomography with area detector for whole-body scans. Investig Radiol. 2020;55(2):73–83.CrossRef
16.
go back to reference Saltybaeva N, Jafari ME, Hupfer M, Kalender WA. Estimates of effective dose for CT scans of the lower extremities. Radiology. 2014;273(1):153–9.CrossRef Saltybaeva N, Jafari ME, Hupfer M, Kalender WA. Estimates of effective dose for CT scans of the lower extremities. Radiology. 2014;273(1):153–9.CrossRef
17.
go back to reference Sato T, Koga Y, Sobue T, Omori G, Tanabe Y, Sakamoto M. Quantitative 3-dimensional analysis of preoperative and postoperative joint lines in Total knee arthroplasty. J Arthroplast. 2007;22(4):560–8.CrossRef Sato T, Koga Y, Sobue T, Omori G, Tanabe Y, Sakamoto M. Quantitative 3-dimensional analysis of preoperative and postoperative joint lines in Total knee arthroplasty. J Arthroplast. 2007;22(4):560–8.CrossRef
18.
go back to reference Wu G, Siegler S, Allard P, Kirtley C, Leardini A, Rosenbaum D, et al. ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion—part I: ankle, hip, and spine. J Biomech. 2002;35(4):543–8.CrossRef Wu G, Siegler S, Allard P, Kirtley C, Leardini A, Rosenbaum D, et al. ISB recommendation on definitions of joint coordinate system of various joints for the reporting of human joint motion—part I: ankle, hip, and spine. J Biomech. 2002;35(4):543–8.CrossRef
19.
go back to reference Gutekunst DJ, Liu L, Ju T, Prior FW, Sinacore DR. Reliability of clinically relevant 3D foot bone angles from quantitative computed tomography. J Foot Ankle Res. 2013;6(1):38.CrossRef Gutekunst DJ, Liu L, Ju T, Prior FW, Sinacore DR. Reliability of clinically relevant 3D foot bone angles from quantitative computed tomography. J Foot Ankle Res. 2013;6(1):38.CrossRef
20.
go back to reference Kellgren JH, Lawrence JS. Radiological assessment of Osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494–502.CrossRef Kellgren JH, Lawrence JS. Radiological assessment of Osteo-arthrosis. Ann Rheum Dis. 1957;16(4):494–502.CrossRef
21.
go back to reference Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159–74.CrossRef Landis JR, Koch GG. The measurement of observer agreement for categorical data. Biometrics. 1977;33(1):159–74.CrossRef
22.
go back to reference Dagneaux L, Dufrenot M, Bernasconi A, Bedard NA, De Cesar Netto C, Lintz F. Three-Dimensional Biometrics to Correlate Hindfoot and Knee Coronal Alignments Using Modern Weightbearing Imaging. Foot Ankle Int. 2020;41(11):1411-1418. Dagneaux L, Dufrenot M, Bernasconi A, Bedard NA, De Cesar Netto C, Lintz F. Three-Dimensional Biometrics to Correlate Hindfoot and Knee Coronal Alignments Using Modern Weightbearing Imaging. Foot Ankle Int. 2020;41(11):1411-1418.
23.
go back to reference Bartoníček J, Rammelt S, Naňka O. Anatomy of the subtalar joint. Foot Ankle Clin. 2018;23(3):315–40.CrossRef Bartoníček J, Rammelt S, Naňka O. Anatomy of the subtalar joint. Foot Ankle Clin. 2018;23(3):315–40.CrossRef
24.
go back to reference Cote KP, Brunet ME, Gansneder BM, Shultz SJ. Effects of pronated and supinated foot postures on static and dynamic postural stability. J Athl Train. 2005;40(1):41–6.PubMedPubMedCentral Cote KP, Brunet ME, Gansneder BM, Shultz SJ. Effects of pronated and supinated foot postures on static and dynamic postural stability. J Athl Train. 2005;40(1):41–6.PubMedPubMedCentral
25.
go back to reference Kaneda K, Harato K, Oki S, Ota T, Yamada Y, Yamada M, Matsumoto M, Nakamura M, Nagura T, Jinzaki M. Three-dimensional kinematic change of hindfoot during full weightbearing in standing: an analysis using upright computed tomography and 3D-3D surface registration. J Orthop Surg Res. 2019;14(1):355-362. Kaneda K, Harato K, Oki S, Ota T, Yamada Y, Yamada M, Matsumoto M, Nakamura M, Nagura T, Jinzaki M. Three-dimensional kinematic change of hindfoot during full weightbearing in standing: an analysis using upright computed tomography and 3D-3D surface registration. J Orthop Surg Res. 2019;14(1):355-362.
26.
go back to reference Gao F, Ma J, Sun W, Guo W, Li Z, Wang W. The influence of knee malalignment on the ankle alignment in varus and valgus gonarthrosis based on radiographic measurement. Eur J Radiol. 2016;85(1):228–32.CrossRef Gao F, Ma J, Sun W, Guo W, Li Z, Wang W. The influence of knee malalignment on the ankle alignment in varus and valgus gonarthrosis based on radiographic measurement. Eur J Radiol. 2016;85(1):228–32.CrossRef
27.
go back to reference Kawahara T, Sasho T, Katsuragi J, Ohnishi T, Haneishi H: Relationship between knee osteoarthritis and meniscal shape in observation of Japanese patients by using magnetic resonance imaging. J Orthop Surg Res. 2017;12(1):97-106. Kawahara T, Sasho T, Katsuragi J, Ohnishi T, Haneishi H: Relationship between knee osteoarthritis and meniscal shape in observation of Japanese patients by using magnetic resonance imaging. J Orthop Surg Res. 2017;12(1):97-106.
28.
go back to reference Fujii T, Sato T, Ariumi A, Omori G, Koga Y, Endo N. A comparative study of weight-bearing and non-weight-bearing 3-dimensional lower extremity alignment in knee osteoarthritis. J Orthop Sci. 2020;25(5):874–9.CrossRef Fujii T, Sato T, Ariumi A, Omori G, Koga Y, Endo N. A comparative study of weight-bearing and non-weight-bearing 3-dimensional lower extremity alignment in knee osteoarthritis. J Orthop Sci. 2020;25(5):874–9.CrossRef
29.
go back to reference Andriacchi TP, Mündermann A. The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis. Curr Opin Rheumatol. 2006;18(5):514–8.CrossRef Andriacchi TP, Mündermann A. The role of ambulatory mechanics in the initiation and progression of knee osteoarthritis. Curr Opin Rheumatol. 2006;18(5):514–8.CrossRef
30.
go back to reference Ota T, Nagura T, Yamada Y, Yamada M, Yokoyama Y, Ogihara N, et al. Effect of natural full weight-bearing during standing on the rotation of the first metatarsal bone. Clin Anat. 2019;32(5):715–21.CrossRef Ota T, Nagura T, Yamada Y, Yamada M, Yokoyama Y, Ogihara N, et al. Effect of natural full weight-bearing during standing on the rotation of the first metatarsal bone. Clin Anat. 2019;32(5):715–21.CrossRef
31.
go back to reference Nie Y, Wang H, Xu B, Zhou Z, Shen B, Pei F. The relationship between knee adduction moment and knee osteoarthritis symptoms according to static alignment and pelvic drop. Biomed Res Int. 2019;2019:1–8. Nie Y, Wang H, Xu B, Zhou Z, Shen B, Pei F. The relationship between knee adduction moment and knee osteoarthritis symptoms according to static alignment and pelvic drop. Biomed Res Int. 2019;2019:1–8.
32.
go back to reference Pisani G. Some words about lower limb torsion and rotation problems. Foot Ankle Surg. 2009;15(1):20–1.CrossRef Pisani G. Some words about lower limb torsion and rotation problems. Foot Ankle Surg. 2009;15(1):20–1.CrossRef
33.
go back to reference De Rooij M, Van Der Leeden M, Heymans MW, Holla JFM, Häkkinen A, Lems WF, et al. Prognosis of pain and physical functioning in patients with knee osteoarthritis: a systematic review and Meta-analysis. Arthritis Care Res. 2016;68(4):481–92.CrossRef De Rooij M, Van Der Leeden M, Heymans MW, Holla JFM, Häkkinen A, Lems WF, et al. Prognosis of pain and physical functioning in patients with knee osteoarthritis: a systematic review and Meta-analysis. Arthritis Care Res. 2016;68(4):481–92.CrossRef
Metadata
Title
Knee varus alters three-dimensional ankle alignment in standing- a study with upright computed tomography
Authors
Satoshi Hakukawa
Kazuya Kaneda
Satoshi Oki
Kengo Harato
Yoshitake Yamada
Yasuo Niki
Takeo Nagura
Masaya Nakamura
Masahiro Jinzaki
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2022
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-022-05235-7

Other articles of this Issue 1/2022

BMC Musculoskeletal Disorders 1/2022 Go to the issue