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BMC Musculoskeletal Disorders

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Open Access 01-12-2021 | Sarcopenia | Research article

Urinary pentosidine level is associated with grip strength and gait speed in community-dwelling adults: a cross-sectional study

Authors: Kenta Moriwaki, Hiromi Matsumoto, Chika Tanimura, Mari Osaki, Hideki Nagashima, Hiroshi Hagino

Published in: BMC Musculoskeletal Disorders | Issue 1/2021

Abstract

Background

Muscle and bone interactions might be associated with osteoporosis and sarcopenia. Urinary pentosidine and serum 25-hydroxyvitamin D (25(OH)D) might affect muscle and bone interactions. It is unclear whether these biomarkers are affected by age and sex or play a role in muscle and physical functions. We aimed to investigate the association between urinary pentosidine and serum 25(OH)D levels with muscle mass, muscle strength, and physical performance in community-dwelling adults.

Methods

Two-hundred and fifty-four middle-aged and elderly adults were enrolled. There was no significant difference in age between 97 men (75.0 ± 8.9 years) and 157 women (73.6 ± 8.1 years). The skeletal muscle mass index (SMI), grip strength, and gait speed were assessed. The urinary pentosidine level was measured. We evaluated the association of urinary pentosidine and serum 25(OH)D levels with age and sex (student’s t-test) and correlations between biomarker and each variable (Pearson’s correlation coefficients). Multiple regression analysis was performed with grip strength and gait speed as dependent variables and with age, height, weight, body mass index (BMI), speed of sound (SOS), SMI, glycated hemoglobin (HbA1c), estimated glomerular filtration rate (eGFR), 25(OH)D, and pentosidine as independent variables using the stepwise method.

Results

The urinary pentosidine level was negatively correlated with grip strength, gait speed, eGFR, and insulin-like growth factor-1 (IGF-1) in men and with SOS, grip strength, and gait speed in women. The serum 25(OH)D level was positively correlated with IGF-1 in women and grip strength in men. Grip strength was associated with age, height, and pentosidine in men and height and pentosidine in women. Gait speed was associated with age, BMI, and pentosidine in men and age, height, and pentosidine in women.

Conclusion

Urinary pentosidine levels are significantly associated with grip strength and gait speed and may serve as a biomarker of muscle and bone interactions.

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Title: Urinary pentosidine level is associated with grip strength and gait speed in community-dwelling adults: a cross-sectional study
Authors: Kenta Moriwaki
Hiromi Matsumoto
Chika Tanimura
Mari Osaki
Hideki Nagashima
Hiroshi Hagino
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Sarcopenia
Insulins
Osteoporosis
Osteoporosis
Insulins
Biomarkers
Published in: BMC Musculoskeletal Disorders / Issue 1/2021
Electronic ISSN: 1471-2474
DOI: https://doi.org/10.1186/s12891-021-04279-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Urinary pentosidine level is associated with grip strength and gait speed in community-dwelling adults: a cross-sectional study

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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