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BMC Psychiatry

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01-12-2020 | Schizophrenia | Research article

Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia

Authors: Wei-Liang Wang, Yu-Qiu Zhou, Nan-Nan Chai, Guo-Hua Li, Dong-Wei Liu

Published in: BMC Psychiatry | Issue 1/2020

Abstract

Background

The underlying mechanism between hope and quality of life is as yet unknown. We aim to examine the potential mediating effect of depression and resilience and the moderated effect of sex in this well-established association.

Methods

Two hundred seven patients diagnosed with schizophrenia were administered a questionnaire battery that measured hope, depression, resilience and QOL. A multiple mediation model was used to examine the mediating effect of resilience and depression on the association between hope and QOL. A subgroup analysis was performed and a moderated mediation model was examined to find and test the moderated effect of sex on the mediation model. We used Mplus to perform moderation and mediation analyses so that the mediators and moderator could function together in the same model.

Result

Sex was the moderator on the direct path between hope and QOL. The relationship between hope and QOL was mediated by resilience and depression in both sexes. When compared with female patients, the effect of hope on QOL was completely mediated by resilience and depression in males. In female patients, the model was partially mediated, and the direct effect of hope on QOL was significantly negatively correlated with the level of hope.

Conclusion

We present a conceptual model containing the mediated effects of resilience and depression and the moderated effect of sex between hope and QOL, which we believe facilitates the understanding of these associations. This model should be useful in the formulation of strategies to improve QOL.

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Title: Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia
Authors: Wei-Liang Wang
Yu-Qiu Zhou
Nan-Nan Chai
Guo-Hua Li
Dong-Wei Liu
Publication date: 01-12-2020
Publisher: BioMed Central
Keywords: Schizophrenia
Mood Disorders
Affective Disorder
Published in: BMC Psychiatry / Issue 1/2020
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-020-2436-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Mediation and moderation analyses: exploring the complex pathways between hope and quality of life among patients with schizophrenia

Abstract

Background

Methods

Result

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Result

Conclusion

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