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Open Access 01-12-2021 | Radiotherapy | Research article

Comparing the 7th and 8th editions of UICC/AJCC staging system for nasopharyngeal carcinoma in the IMRT era

Authors: Tao He, Ruo-Nan Yan, Hua-Ying Chen, Yuan-Yuan Zeng, Zhong-Zheng Xiang, Fang Liu, Bian-Fei Shao, Jia-Chun Ma, Xi-Ran Wang, Lei Liu

Published in: BMC Cancer | Issue 1/2021

Abstract

Background

To compare the prognostic value of 7th and 8th editions of the Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system for patients with nonmetastatic nasopharyngeal carcinoma (NPC) treated with intensity-modulated radiotherapy and simultaneous integrated boost– intensity-modulated radiation therapy (SIB-IMRT).

Methods

Patients with NPC (n = 300) who received SIB-IMRT were included. Survival by T-classification, N-classification, and stage group of each staging system was assessed.

Results

For T-classification, nonsignificant difference was observed between T1 and T3 and between T2 and T3 disease (P = 0.066 and 0.106, respectively) for overall survival (OS) in the 7th staging system, whereas all these differences were significant in the 8th staging system (all P < 0.05). The survival curves for disease-free survival (DFS) and locoregional recurrence-free survival (LRRFS) in both staging systems were similar, except for the comparison of T2 and T4 disease for LRRFS (P = 0.070 for 7th edition; P = 0.011 for 8th edition). For N-classification, significant differences were observed between N2 and N3 diseases after revision (P = 0.046 and P = 0.043 for OS and DFS, respectively). For staging system, no significant difference was observed between IVA and IVB of 7th edition.

Conclusion

The 8th AJCC staging system appeared to have superior prognosis value in the SIB-IMRT era compared with the 7th edition.

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Title: Comparing the 7th and 8th editions of UICC/AJCC staging system for nasopharyngeal carcinoma in the IMRT era
Authors: Tao He
Ruo-Nan Yan
Hua-Ying Chen
Yuan-Yuan Zeng
Zhong-Zheng Xiang
Fang Liu
Bian-Fei Shao
Jia-Chun Ma
Xi-Ran Wang
Lei Liu
Publication date: 01-12-2021
Publisher: BioMed Central
Keyword: Radiotherapy
Published in: BMC Cancer / Issue 1/2021
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-021-08036-8

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