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BMC Cancer
Published in: BMC Cancer 1/2018

Open Access 01-12-2018 | Research article

Evaluation of efficacy and safety for Brucea javanica oil emulsion in the control of the malignant pleural effusions via thoracic perfusion

Authors: Dai Fuhong, Gao Xiang, Li Haiying, Wang Jiangye, Gao Xueming, Chai Wenxiao

Published in: BMC Cancer | Issue 1/2018

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Abstract

Background

Brucea javanica oil emulsion (BJOE) is traditional Chinese medicine with implicated anti-tumor activity, which has been used for treating lung cancer in China. The aim of this investigation was to evaluate the effects and safety of intrapleural injection of BJOE in treating malignant pleural effusion (MPE).

Methods

The randomised controlled trials (RCTs) on the effects and safety of BJOE in treating MPE were searched from electronic medical database including MEDLINE, SCI, EMBASE, Cochrance Library and CNKI. A total of 14 RCTs with 1085 patients were involved in this meta-analysis.

Results

The overall response rate (ORR) of traditional chemotherapy drugs plus BJOE was higher than that of traditional chemotherapy drugs alone (p = 0.001; odds ratio = 1.39). Meanwhile, the combination of BJOE and traditional chemotherapy drugs improved the quality of life (QOL) of patients with MPE (p < 0.001; odds ratio = 1.56) compared with traditional chemotherapy drugs alone. Moreover, the participation of BJOE reduced the myelotoxicity and digestive reactions caused by traditional chemotherapy drugs (p < 0.05).

Conclusions

The efficacy and safety of traditional chemotherapy drugs plus BJOE was superior to traditional chemotherapy drugs alone via intrapleural injection in controlling MPE, which suggested that BJOE can be used to treat MPE.
Literature
1.
Dixit R, Agarwal KC, Gokhroo A, Patil CB, Meena M, Shah NS, et al. Diagnosis and management options in malignant pleural effusions. Lung India. 2017;34(2):160–6.CrossRefPubMedPubMedCentral
2.
Biaoxue R, Xiguang C, Hua L, Wenlong G, Shuanying Y. Thoracic perfusion of recombinant human endostatin (Endostar) combined with chemotherapeutic agents versus chemotherapeutic agents alone for treating malignant pleural effusions: a systematic evaluation and meta-analysis. BMC Cancer. 2016;16(1):888.CrossRefPubMedPubMedCentral
3.
Biaoxue R, Hui P, Wenlong G, Shuanying Y. Evaluation of efficacy and safety for recombinant human adenovirus-p53 in the control of the malignant pleural effusions via thoracic perfusion. Sci Rep. 2016;6:39355.CrossRefPubMedPubMedCentral
4.
Psallidas I, Kalomenidis I, Porcel JM, Robinson BW, Stathopoulos GT. Malignant pleural effusion: from bench to bedside. Eur Respir Rev. 2016;25(140):189–98.CrossRefPubMed
5.
Azzopardi M, Porcel JM, Koegelenberg CF, Lee YC, Fysh ET. Current controversies in the management of malignant pleural effusions. Semin Respir Crit Care Med. 2014;35(6):723–31.CrossRefPubMed
6.
Biaoxue R, Shuxia M, Wenlong G, Shuanying Y. Thoracic perfusion of matrine as an adjuvant treatment improves the control of the malignant pleural effusions. World J Surg Oncol. 2015;13:329.CrossRefPubMedPubMedCentral
7.
Xu W, Jiang X, Xu Z, Ye T, Shi Q. The efficacy of Brucea javanica oil emulsion injection as adjunctive therapy for advanced non-small-cell lung Cancer: a meta-analysis. Evid Based Complement Alternat Med. 2016;2016:5928562.PubMedPubMedCentral
8.
Ma S, Chen F, Ye X, Dong Y, Xue Y, Xu H, et al. Intravenous microemulsion of docetaxel containing an anti-tumor synergistic ingredient (Brucea javanica oil): formulation and pharmacokinetics. Int J Nanomedicine. 2013;8:4045–52.PubMedPubMedCentral
9.
Liu TT, Mu LQ, Dai W, Wang CB, Liu XY, Xiang DX. Preparation, characterization, and evaluation of antitumor effect of Brucea javanica oil cationic nanoemulsions. Int J Nanomedicine. 2016;11:2515–29.CrossRefPubMedPubMedCentral
10.
Yan Z, Zhang B, Huang Y, Qiu H, Chen P, Guo GF. Involvement of autophagy inhibition in Brucea javanica oil emulsion-induced colon cancer cell death. Oncol Lett. 2015;9(3):1425–31.CrossRefPubMedPubMedCentral
11.
Wang Q, Wang M, He X, Gao T, Cao H, Dou W, et al. Meta-analysis on treatment of non-small cell lung cancer with brucea javanica oil emulsion in combination with platinum-contained first-line chemotherapy. Zhongguo Zhong Yao Za Zhi. 2012;37(13):2022–9.PubMed
12.
Liu J, Huang XE, Tian GY, Cao J, Lu YY, Wu XY, et al. Phase II study on safety and efficacy of Yadanzi(R) (Javanica oil emulsion injection) combined with chemotherapy for patients with gastric cancer. Asian Pac J Cancer Prev. 2013;14(3):2009–12.CrossRefPubMed
13.
Guo Y, Wu J, Yang H, Cao C. Treatment of malignant pleural effusion with Brucea javanica oil emulsion combined with cisplatin intravesical injection (in Chinese). J Oncol. 2004;10(2):129–30.
14.
Lei H, Zhao Y, Su L. Treatment of 111 cases of malignant pleural effusion by brucea javanica oil emulsion combined with chemotherapy (in Chinese). Ningxia Med J. 2006;28(5):372–3.
15.
Wang H, Liao G, Liu P, Qu Y, Xie G, Liu S. Brucea javanica oil emulsion combined with cisplatin treatment for 70 patients with malignant pleural effusion of lung cancer (in Chinese). Chinese cancer. 2007;16(12):1035–6.
16.
Wu S, Rui L, Hong Y. Clinical observation on 68 cases of cancerous pleural effusion treated by brucea javanica oil emulsion combined with cisplatin (in Chinese). Hai Nan Med J. 2009;20(9):14–5.
17.
Fu X, Fu S, Yang G, Xue Y, Chen L, Yu S. Observation on the curative effect of continuous drainage combined with brucea javanica oil and cisplatin in the treatment of malignant pleural effusion (in Chinese). Clin J Med Offic. 2009;37(5):818–20.
18.
Chen Y. Therapeutic effect of brucea javanica oil emulsion combined with cisplatin in the treatment of malignant pleural effusion (in Chinese). Zhejiang J I T C W M. 2011;21(10):713–4.
19.
Jia L, Wang Y, Geng L. Treatment of 35 cases of malignant pleural effusion using brucea javanica oil emulsion combined with oxaliplatin (in Chinese). J Tradit Chin Med. 2011;52(22):1956–7.
20.
Liu B, Zhang L. Clinical observation of brucea javanica oil emulsion and cisplatinum on treating lung cancer malignant pleural effussion (in Chinese). China Modern Med. 2012;19(7):47–8
21.
Zhang J, Liu X. The results of 28 patients with pleural effusion of lung cancer treated with brucea javanice oil emulsion combined with bleomycin hydrochloride for injection (in Chinese). Pract J Cancer. 2012;27(5):500–2.
22.
Zhang H, Jing D, Zhao Y. Treatment of 34 cases of malignant pleural effusion with brucea javanica oil and cisplatin (in Chinese). Modern Distance Education of Chinese Med. 2013;11(5):41–2.
23.
Yang G, Song C. Clinical observation of Brucea javanica oil emulsion combined with cisplatin in the treatment of malignant pleural effusion (in Chinese). China Foreign Med Treatment. 2014;13:142–5.
24.
Yang H, Wu M. Clinical observation of cisplatin and interleukin-II combined with brucea javanica oil emulsion in the treatment of malignant pleural effusion caused by lung cancer (in Chinese). J Clin Pulmonary Med. 2014;19(10):1857–62.
25.
Yue K. Efficacy of Brucea javanica oil emulsion combined with cisplatin in the treatment of pleural effusion of lung cancer (in Chinese). J Med Theor Prac. 2016;29(9):1164–5.
26.
Wang C, Sun C. Thirty cases of lung cancer pleural effusion treated with brucea javanica oil emulsion in combination with cisplatin (in Chinese). Henan Traditional Chinese Med. 2016;36(4):665–6.
27.
Biaoxue R, Hua L, Wenlong G, Shuanying Y. Increased serum amyloid a as potential diagnostic marker for lung cancer: a meta-analysis based on nine studies. BMC Cancer. 2016;16(1):836.CrossRefPubMedPubMedCentral
28.
Jin W, Han H, Zhou S, Wang Y, Dong T, Zhao C. Therapeutic efficacy of brucea javanica oil emulsion (BJOE) combined with transcatheter hepatic arterial chemoembolization (TACE) in patients with primary liver cancer. Int J Clin Exp Med. 2015;8(10):18954–62.PubMedPubMedCentral
29.
Lou GG, Yao HP, Xie LP. Brucea javanica oil induces apoptosis in T24 bladder cancer cells via upregulation of caspase-3, caspase-9, and inhibition of NF-kappaB and COX-2 expressions. Am J Chin Med. 2010;38(3):613–24.CrossRefPubMed
30.
Qin LJ, Jia YS, Zhao XQ, Zhang T, Zhang W, Sun N. Effect of Brucea Javanica oil emulsion on the invasiveness of glioma cells and its possible mechanism. Sichuan Da Xue Xue Bao Yi Xue Ban. 2016;47(3):347–50.PubMed
31.
Yue Y, Yang Y, Shi L, Wang Z. Suppression of human hepatocellular cancer cell proliferation by Brucea javanica oil-loaded liposomes via induction of apoptosis. Arch Med Sci. 2015;11(4):856–62.CrossRefPubMedPubMedCentral
32.
Anota A, Hamidou Z, Paget-Bailly S, Chibaudel B, Bascoul-Mollevi C, Auquier P, et al. Time to health-related quality of life score deterioration as a modality of longitudinal analysis for health-related quality of life studies in oncology: do we need RECIST for quality of life to achieve standardization? Qual Life Res. 2015;24(1):5–18.CrossRefPubMed
33.
Nie YL, Liu KX, Mao XY, Li YL, Li J, Zhang MM. Effect of injection of brucea javanica oil emulsion plus chemoradiotherapy for lung cancer: a review of clinical evidence. J Evid Based Med. 2012;5(4):216–25.CrossRefPubMed
34.
Waissbluth S, Peleva E, Daniel SJ. Platinum-induced ototoxicity: a review of prevailing ototoxicity criteria. Eur Arch Otorhinolaryngol. 2017;274(3):1187–96.CrossRefPubMed
35.
Biaoxue R, Shuanying Y, Xiguang C, Wei Z, Wei L. Differential diagnostic CYFRA 21-1 level for benign and malignant pleural effusions: a meta-analysis in the Chinese population. Arch Med Sci. 2012;8(5):756–66.CrossRefPubMedPubMedCentral
Metadata
Title
Evaluation of efficacy and safety for Brucea javanica oil emulsion in the control of the malignant pleural effusions via thoracic perfusion
Authors
Dai Fuhong
Gao Xiang
Li Haiying
Wang Jiangye
Gao Xueming
Chai Wenxiao
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI
https://doi.org/10.1186/s12885-018-4328-3

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