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BMC Neurology

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Open Access 29-08-2023 | Disease of Central Nervous System | Case report

Primary lateral sclerosis plus parkinsonism: a case report

Authors: Abhaya Moturu, Wade Welch

Published in: BMC Neurology | Issue 1/2023

Abstract

Background

The standard of diagnosing primary lateral sclerosis, the Pringle criteria, requires three years of purely upper motor neuron symptom presentation before confirming diagnosis. This classic standard has been questioned on occasion due to its restrictive range of both time period and symptomatic exhibition.

Case presentation

This case report will review a 57-year-old Caucasian female who presented with pyramidal and extrapyramidal features suggestive of the exceedingly rare disease primary lateral sclerosis plus parkinsonism. We will describe the mixture of upper motor neuron signs and striking parkinsonian symptoms experienced by the patient, as well as the full diagnostic workup leading to her preliminary diagnosis. The details of this case will then be utilized to explore the diagnostic criteria of primary lateral sclerosis, as well as to work through the differential of conditions resembling Parkinson’s disease.

Conclusions

The current criteria to diagnose primary lateral sclerosis may be excluding patients with the disease and is an ongoing area of investigation. A thorough differential including other neurodegenerative conditions is necessary to consider and requires long-term follow-up.

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Title: Primary lateral sclerosis plus parkinsonism: a case report
Authors: Abhaya Moturu
Wade Welch
Publication date: 29-08-2023
Publisher: BioMed Central
Keywords: Disease of Central Nervous System
Movement Disorder
Atypical Parkinsonism
Published in: BMC Neurology / Issue 1/2023
Electronic ISSN: 1471-2377
DOI: https://doi.org/10.1186/s12883-023-03360-x

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Primary lateral sclerosis plus parkinsonism: a case report

Abstract

Background

Case presentation

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Case presentation

Conclusions

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