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Published in: BMC Neurology 1/2022

Open Access 01-12-2022 | Stroke | Study protocol

Effectiveness of action observation therapy based on virtual reality technology in the motor rehabilitation of paretic stroke patients: a randomized clinical trial

Authors: Antonino Errante, Donatella Saviola, Matteo Cantoni, Katia Iannuzzelli, Settimio Ziccarelli, Fabrizio Togni, Marcello Simonini, Carolina Malchiodi, Debora Bertoni, Maria Grazia Inzaghi, Francesca Bozzetti, Roberto Menozzi, Annamaria Quarenghi, Paola Quarenghi, Daniele Bosone, Leonardo Fogassi, Gian Piero Salvi, Antonio De Tanti

Published in: BMC Neurology | Issue 1/2022

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Abstract

Background

The rehabilitation of paretic stroke patients uses a wide range of intervention programs to improve the function of impaired upper limb. A new rehabilitative approach, called action observation therapy (AOT) is based on the discovery of mirror neurons and has been used to improve the motor functions of adult stroke patients and children with cerebral palsy. Recently, virtual reality (VR) has provided the potential to increase the frequency and effectiveness of rehabilitation treatment by offering challenging and motivating tasks. 

Methods

The purpose of the present project is to design a randomized controlled six-month follow-up trial (RCT) to evaluate whether action observation (AO) added to standard VR (AO + VR) is effective in improving upper limb function in patients with stroke, compared with a control treatment consisting of observation of naturalistic scenes (CO) without any action content, followed by VR training (CO + VR).

Discussion

AO + VR treatment may provide an addition to the rehabilitative interventions currently available for recovery after stroke and could be utilized within standard sensorimotor training or in individualized tele-rehabilitation.

Trial registration

The trial has been prospectively registered on ClinicalTrials.gov. NCT05163210. 17 December 2021. 
Appendix
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Metadata
Title
Effectiveness of action observation therapy based on virtual reality technology in the motor rehabilitation of paretic stroke patients: a randomized clinical trial
Authors
Antonino Errante
Donatella Saviola
Matteo Cantoni
Katia Iannuzzelli
Settimio Ziccarelli
Fabrizio Togni
Marcello Simonini
Carolina Malchiodi
Debora Bertoni
Maria Grazia Inzaghi
Francesca Bozzetti
Roberto Menozzi
Annamaria Quarenghi
Paola Quarenghi
Daniele Bosone
Leonardo Fogassi
Gian Piero Salvi
Antonio De Tanti
Publication date
01-12-2022
Publisher
BioMed Central
Keyword
Stroke
Published in
BMC Neurology / Issue 1/2022
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-022-02640-2

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