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BMC Neurology
Published in: BMC Neurology 1/2020

Open Access 01-12-2020 | Dementia | Study protocol

Sensor-based systems for early detection of dementia (SENDA): a study protocol for a prospective cohort sequential study

Authors: Katrin Müller, Stephanie Fröhlich, Andresa M. C. Germano, Jyothsna Kondragunta, Maria Fernanda del Carmen Agoitia Hurtado, Julian Rudisch, Daniel Schmidt, Gangolf Hirtz, Peter Stollmann, Claudia Voelcker-Rehage

Published in: BMC Neurology | Issue 1/2020

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Abstract

Background

Dementia and cognitive decline are serious social and economic burdens. An increase in the population of older people, as well as longer lifespans mean that numbers of dementia cases are exponentially rising. Neuropathological changes associated with dementia are thought to appear before the clinical manifestation of cognitive symptoms, i.e., memory impairments. Further, some older adults (OA) experience cognitive decline before it can be objectively diagnosed. For optimal care of these patients, it is necessary to detect cognitive decline and dementia at an early stage. In this vein, motor, sensory, and neurophysiological declines could be promising factors if found to be present before the onset of cognitive impairment. Hence, the objective of the SENDA study is to develop a multi-dimensional sensor-based instrument that allows early detection of cognitive decline or dementia in OA with the help of cognitive, sensory, motor, and neurophysiological parameters before its clinical manifestation.

Methods/design

In the cohort sequential study, participants are assigned to one of three study groups depending on their cognitive status: 1. cognitively healthy individuals (CHI), 2. subjectively cognitively impaired persons (SCI), or 3. (possible) mildly cognitively impaired persons (pMCI, MCI). All groups take part in the same cognitive (e.g., executive function tests), motor (e.g., gait analyses, balance tests), sensory (e.g., vibration perception threshold test, proprioception tests), and neurophysiological (e.g., electroencephalograms) measurements. Depending on the time at which participants are included into the study, all measurements are repeated up to four times in intervals of 8 months within 3 years to identify associations with cognitive changes over time.

Discussion

This study aims to detect possible motor, sensory, neurophysiological, and cognitive predictors to develop an early screening tool for dementia and its pre-stages in OA. Thus, affected persons could receive optimal health care at an earlier time point to maintain their health resources.

Trial status

The study is ongoing. The recruitment of participants will be continued until May 2020.
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Metadata
Title
Sensor-based systems for early detection of dementia (SENDA): a study protocol for a prospective cohort sequential study
Authors
Katrin Müller
Stephanie Fröhlich
Andresa M. C. Germano
Jyothsna Kondragunta
Maria Fernanda del Carmen Agoitia Hurtado
Julian Rudisch
Daniel Schmidt
Gangolf Hirtz
Peter Stollmann
Claudia Voelcker-Rehage
Publication date
01-12-2020
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2020
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/s12883-020-01666-8

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Pain reduction by inducing sensory-motor adaptation in Complex Regional Pain Syndrome (CRPS PRISMA): protocol for a double-blind randomized controlled trial

Research article

Head and neck CT angiography to assess the internal carotid artery stealing pathway

Research article

Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study

Research article

Restless abdomen: a spectrum or a phenotype variant of restless legs syndrome?