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BMC Nephrology
Published in: BMC Nephrology 1/2016

Open Access 01-12-2016 | Study protocol

LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol

Authors: Shiromani Janki, Karel W. J. Klop, Hendrikus J. A. N. Kimenai, Jacqueline van de Wetering, Willem Weimar, Emma K. Massey, Abbas Dehghan, Dimitris Rizopoulos, Henry Völzke, Albert Hofman, Jan N. M. Ijzermans

Published in: BMC Nephrology | Issue 1/2016

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Abstract

Background

The benefits of live donor kidney transplantation must be balanced against the potential harm to the donor. Well-designed prospective studies are needed to study the long-term consequences of kidney donation.

Methods

The “LOng-term follow-up after liVE kidney donation” (LOVE) study is a single center longitudinal cohort study on long-term consequences after living kidney donation. We will study individuals who have donated a kidney from 1981 through 2010 in the Erasmus University Medical Center in Rotterdam, The Netherlands. In this time period, 1092 individuals donated a kidney and contact information is available for all individuals. Each participating donor will be matched (1:4) to non-donors derived from the population-based cohort studies of the Rotterdam Study and the Study of Health in Pomerania. Matching will be based on baseline age, gender, BMI, ethnicity, kidney function, blood pressure, pre-existing co-morbidity, smoking, the use of alcohol and highest education degree. Follow-up data is collected on kidney function, kidney-related comorbidity, mortality, quality of life and psychological outcomes in all participants.

Discussion

This study will provide evidence on the long-term consequences of live kidney donation for the donor compared to matched non-donors and evaluate the current donor eligibility criteria.

Trial registration

Dutch Trial Register NTR3795.
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Metadata
Title
LOng-term follow-up after liVE kidney donation (LOVE) study: a longitudinal comparison study protocol
Authors
Shiromani Janki
Karel W. J. Klop
Hendrikus J. A. N. Kimenai
Jacqueline van de Wetering
Willem Weimar
Emma K. Massey
Abbas Dehghan
Dimitris Rizopoulos
Henry Völzke
Albert Hofman
Jan N. M. Ijzermans
Publication date
01-12-2016
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2016
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-016-0227-5

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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