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BMC Nephrology
Published in: BMC Nephrology 1/2015

Open Access 01-12-2015 | Research article

Genetic predisposition to acute kidney injury – a systematic review

Authors: Laura M. Vilander, Mari A. Kaunisto, Ville Pettilä

Published in: BMC Nephrology | Issue 1/2015

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Abstract

Background

The risk of an individual to develop an acute kidney injury (AKI), or its severity, cannot be reliably predicted by common clinical risk factors. Whether genetic risk factors have an explanatory role poses an interesting question, however. Thus, we conducted a systematic literature review regarding genetic predisposition to AKI or outcome of AKI patients.

Methods

We searched Ovid SP (MEDLINE) and EMBASE databases and found 4027 references to AKI. Based on titles and abstracts, we approved 37 articles for further analysis. Nine were published only as abstracts, leaving 28 original articles in the final analysis. We extracted the first author, year of publication, study design, clinical setting, number of studied patients, patients with AKI, ethnicity of patients, studied polymorphisms, endpoints, AKI definition, phenotype, significant findings, and data for quality scoring from each article. We summarized the findings and scored the quality of articles.

Results

The articles were quite heterogeneous and of moderate quality (mean 6.4 of 10).

Conclusions

Despite different gene polymorphisms with suggested associations with development or severity or outcome of AKI, definitive conclusions would require replication of associations in independent cohort studies and, preferably a hypothesis-free study design.
Appendix
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Metadata
Title
Genetic predisposition to acute kidney injury – a systematic review
Authors
Laura M. Vilander
Mari A. Kaunisto
Ville Pettilä
Publication date
01-12-2015
Publisher
BioMed Central
Published in
BMC Nephrology / Issue 1/2015
Electronic ISSN: 1471-2369
DOI
https://doi.org/10.1186/s12882-015-0190-6

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