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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2024

Open Access 01-12-2024 | Influenza | Research

Platelet distribution width as an useful indicator of influenza severity in children

Authors: Seyin Zou, Siti Hasmah Mohtar, Roshani Othman, Rodiah Mohd Hassan, Kun Liang, Da Lei, Bangming Xu

Published in: BMC Infectious Diseases | Issue 1/2024

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Abstract

Purpose

The present study aims to investigate the potential of platelet distribution width as an useful parameter to assess the severity of influenza in children.

Methods

Baseline characteristics and laboratory results were collected and analyzed. Receiver operating characteristic (ROC) curve analysis was used to joint detection of inflammatory markers for influenza positive children, and the scatter-dot plots were used to compare the differences between severe and non-severe group.

Results

Influenza B positive children had more bronchitis and pneumonia (P < 0.05), influenza A infected children had more other serious symptoms (P = 0.007). Neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio (NLR), and platelet parameters performed differently among < 4 years and ≥ 4 years children with influenza. Combined detection of platelet parameters and other indicators could better separate healthy children from influenza infected children than single indicator detection. The levels of platelet distribution width of children with severe influenza (A and B) infection was significantly dropped, compared with non-severe group (P < 0.05).

Conclusions

Platelet distribution width could be a very useful and economic indicator in distinction and severity assessment for children with influenza.
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Metadata
Title
Platelet distribution width as an useful indicator of influenza severity in children
Authors
Seyin Zou
Siti Hasmah Mohtar
Roshani Othman
Rodiah Mohd Hassan
Kun Liang
Da Lei
Bangming Xu
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2024
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-023-08890-w

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