Skip to main content
Top
Published in: BMC Anesthesiology 1/2020

Open Access 01-12-2020 | Care | Research article

Mortality in severely injured patients: nearly one of five non-survivors have been already discharged alive from ICU

Authors: Uwe Hamsen, Niklas Drotleff, Rolf Lefering, Julius Gerstmeyer, Thomas Armin Schildhauer, Christian Waydhas, TraumaRegister DGU 

Published in: BMC Anesthesiology | Issue 1/2020

Login to get access

Abstract

Background

Most trauma patients admitted to the hospital alive and die later on, decease during the initial care in the emergency department or the intensive care unit (ICU). However, a number of patients pass away after having been discharged from the ICU during the initial hospital stay. On first sight these cases could be seen as “failure to rescue” of potentially salvageable patients. A low rate of such patients might be a potential indicator of quality for trauma care on ICUs and surgical wards.

Methods

Retrospective analysis of the TraumaRegister DGU® with data from 2015 to 2017. Patients that died during the initial ICU stay were compared to those who were discharged from the initial ICU stay for at least 24 h but died later on.

Results

A total of 82,313 trauma patients were included in the TraumaRegister DGU®. In total, 6576 patients (8.0%) died during their hospital stay. Out of those, 5481 were admitted to the ICU alive and 972 patients (17.7%) were discharged from ICU and died later on. Those were older (mean age: 77 vs. 68 years), less severely injured (mean ISS: 23.1 vs. 30.0 points) and had a longer mean ICU length of stay (10 vs. 6 days). A limitation of life-sustaining therapy due to a documented living will was present in 46.1% of all patients who died during their initial ICU stay and in 59.9% of patients who died after discharge from their initial ICU stay.

Conclusions

17.7% of all non-surviving severely injured trauma patients died within the hospital after discharge from their initial ICU treatment. Their death can partially be explained by a limitation of therapy due to a living will. In conclusion, the rate of such late deaths may partially represent patients that died of potentially avoidable or treatable complications.
Literature
2.
go back to reference Regel G, Lobenhoffer P, Grotz M, Pape HC, Lehmann U, Tscherne H. Treatment results of patients with multiple trauma: an analysis of 3406 cases treated between 1972 and 1991 at a German level I trauma center. J Trauma. 1995;38(1):70–8.PubMed Regel G, Lobenhoffer P, Grotz M, Pape HC, Lehmann U, Tscherne H. Treatment results of patients with multiple trauma: an analysis of 3406 cases treated between 1972 and 1991 at a German level I trauma center. J Trauma. 1995;38(1):70–8.PubMed
3.
go back to reference Ruchholtz S, Lefering R, Paffrath T, Oestern HJ, Neugebauer E, Nast-Kolb D, et al. Reduction in mortality of severely injured patients in Germany. Dtsch Arztebl Int. 2008;105(13):225–31.PubMedPubMedCentral Ruchholtz S, Lefering R, Paffrath T, Oestern HJ, Neugebauer E, Nast-Kolb D, et al. Reduction in mortality of severely injured patients in Germany. Dtsch Arztebl Int. 2008;105(13):225–31.PubMedPubMedCentral
4.
go back to reference Bieler D, Horster A, Lefering R, Franke A, Waydhas C, Huber-Wagner S, et al. Evaluation of new quality indicators for the TraumaRegister DGU((R)) using the systematic QUALIFY methodology. Eur J Trauma Emerg Surg. 2018;46(3):449.PubMed Bieler D, Horster A, Lefering R, Franke A, Waydhas C, Huber-Wagner S, et al. Evaluation of new quality indicators for the TraumaRegister DGU((R)) using the systematic QUALIFY methodology. Eur J Trauma Emerg Surg. 2018;46(3):449.PubMed
5.
go back to reference Waydhas C, Baake M, Becker L, Buck B, Dusing H, Heindl B, et al. A consensus-based criterion standard for the requirement of a trauma team. World J Surg. 2018;42(9):2800–9.PubMed Waydhas C, Baake M, Becker L, Buck B, Dusing H, Heindl B, et al. A consensus-based criterion standard for the requirement of a trauma team. World J Surg. 2018;42(9):2800–9.PubMed
6.
go back to reference Patel SJ, Saiman L. Principles and strategies of antimicrobial stewardship in the neonatal intensive care unit. Semin Perinatol. 2012;36(6):431–6.PubMedPubMedCentral Patel SJ, Saiman L. Principles and strategies of antimicrobial stewardship in the neonatal intensive care unit. Semin Perinatol. 2012;36(6):431–6.PubMedPubMedCentral
7.
go back to reference Hamsen U, Lefering R, Fisahn C, Schildhauer TA, Waydhas C. Workload and severity of illness of patients on intensive care units with available intermediate care units: a multicentre cohort study. Minerva Anestesiol. 2018;84(8):938.PubMed Hamsen U, Lefering R, Fisahn C, Schildhauer TA, Waydhas C. Workload and severity of illness of patients on intensive care units with available intermediate care units: a multicentre cohort study. Minerva Anestesiol. 2018;84(8):938.PubMed
8.
go back to reference Rosenberg AL, Hofer TP, Hayward RA, Strachan C, Watts CM. Who bounces back? Physiologic and other predictors of intensive care unit readmission. Crit Care Med. 2001;29(3):511–8.PubMed Rosenberg AL, Hofer TP, Hayward RA, Strachan C, Watts CM. Who bounces back? Physiologic and other predictors of intensive care unit readmission. Crit Care Med. 2001;29(3):511–8.PubMed
9.
go back to reference Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, et al. Mortality after surgery in Europe: a 7 day cohort study. Lancet. 2012;380(9847):1059–65.PubMedPubMedCentral Pearse RM, Moreno RP, Bauer P, Pelosi P, Metnitz P, Spies C, et al. Mortality after surgery in Europe: a 7 day cohort study. Lancet. 2012;380(9847):1059–65.PubMedPubMedCentral
10.
go back to reference Ghaferi AA, Birkmeyer JD, Dimick JB. Variation in hospital mortality associated with inpatient surgery. N Engl J Med. 2009;361(14):1368–75.PubMed Ghaferi AA, Birkmeyer JD, Dimick JB. Variation in hospital mortality associated with inpatient surgery. N Engl J Med. 2009;361(14):1368–75.PubMed
11.
go back to reference Churpek MM, Yuen TC, Edelson DP. Risk stratification of hospitalized patients on the wards. Chest. 2013;143(6):1758–65.PubMedPubMedCentral Churpek MM, Yuen TC, Edelson DP. Risk stratification of hospitalized patients on the wards. Chest. 2013;143(6):1758–65.PubMedPubMedCentral
12.
go back to reference Maharaj R, Raffaele I, Wendon J. Rapid response systems: a systematic review and meta-analysis. Crit Care. 2015;19:254.PubMedPubMedCentral Maharaj R, Raffaele I, Wendon J. Rapid response systems: a systematic review and meta-analysis. Crit Care. 2015;19:254.PubMedPubMedCentral
13.
go back to reference Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, et al. Rapid response team and hospital mortality in hospitalized patients. Intensive Care Med. 2016;42(4):494–504.PubMed Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, et al. Rapid response team and hospital mortality in hospitalized patients. Intensive Care Med. 2016;42(4):494–504.PubMed
14.
go back to reference Silber JH, Williams SV, Krakauer H, Schwartz JS. Hospital and patient characteristics associated with death after surgery. A study of adverse occurrence and failure to rescue. Med Care. 1992;30(7):615–29.PubMed Silber JH, Williams SV, Krakauer H, Schwartz JS. Hospital and patient characteristics associated with death after surgery. A study of adverse occurrence and failure to rescue. Med Care. 1992;30(7):615–29.PubMed
15.
go back to reference Hatchimonji JS, Kaufman EJ, Sharoky CE, Ma L, Garcia Whitlock AE, Holena DN. Failure to Rescue in Surgical Patients: a review for acute care surgeons. J Trauma Acute Care Surg. 2019;87(3):699.PubMedPubMedCentral Hatchimonji JS, Kaufman EJ, Sharoky CE, Ma L, Garcia Whitlock AE, Holena DN. Failure to Rescue in Surgical Patients: a review for acute care surgeons. J Trauma Acute Care Surg. 2019;87(3):699.PubMedPubMedCentral
16.
go back to reference Barmparas G, Ley EJ, Martin MJ, Ko A, Harada M, Weigmann D, et al. Failure to rescue the elderly: a superior quality metric for trauma centers. Eur J Trauma Emerg Surg 2017;44(3):]. Barmparas G, Ley EJ, Martin MJ, Ko A, Harada M, Weigmann D, et al. Failure to rescue the elderly: a superior quality metric for trauma centers. Eur J Trauma Emerg Surg 2017;44(3):].
17.
go back to reference Stewart RM, Myers JG, Dent DL, Ermis P, Gray GA, Villarreal R, et al. Seven hundred fifty-three consecutive deaths in a level I trauma center: the argument for injury prevention. J Trauma. 2003;54(1):66–70 discussion −1.PubMed Stewart RM, Myers JG, Dent DL, Ermis P, Gray GA, Villarreal R, et al. Seven hundred fifty-three consecutive deaths in a level I trauma center: the argument for injury prevention. J Trauma. 2003;54(1):66–70 discussion −1.PubMed
18.
go back to reference Zhang Z. Univariate description and bivariate statistical inference: the first step delving into data. Ann Transl Med. 2016;4(5):91.PubMedPubMedCentral Zhang Z. Univariate description and bivariate statistical inference: the first step delving into data. Ann Transl Med. 2016;4(5):91.PubMedPubMedCentral
19.
go back to reference Azevedo LC, de Souza IA, Zygun DA, Stelfox HT, Bagshaw SM. Association between nighttime discharge from the intensive care unit and hospital mortality: a multi-center retrospective cohort study. BMC Health Serv Res. 2015;15:378.PubMedPubMedCentral Azevedo LC, de Souza IA, Zygun DA, Stelfox HT, Bagshaw SM. Association between nighttime discharge from the intensive care unit and hospital mortality: a multi-center retrospective cohort study. BMC Health Serv Res. 2015;15:378.PubMedPubMedCentral
20.
go back to reference Gillies MA, Harrison EM, Pearse RM, Garrioch S, Haddow C, Smyth L, et al. Intensive care utilization and outcomes after high-risk surgery in Scotland: a population-based cohort study. Br J Anaesth. 2017;118(1):123–31.PubMed Gillies MA, Harrison EM, Pearse RM, Garrioch S, Haddow C, Smyth L, et al. Intensive care utilization and outcomes after high-risk surgery in Scotland: a population-based cohort study. Br J Anaesth. 2017;118(1):123–31.PubMed
21.
go back to reference Hosein FS, Roberts DJ, Turin TC, Zygun D, Ghali WA, Stelfox HT. A meta-analysis to derive literature-based benchmarks for readmission and hospital mortality after patient discharge from intensive care. Crit Care. 2014;18(6):715.PubMedPubMedCentral Hosein FS, Roberts DJ, Turin TC, Zygun D, Ghali WA, Stelfox HT. A meta-analysis to derive literature-based benchmarks for readmission and hospital mortality after patient discharge from intensive care. Crit Care. 2014;18(6):715.PubMedPubMedCentral
22.
go back to reference Churpek MM, Wendlandt B, Zadravecz FJ, Adhikari R, Winslow C, Edelson DP. Association between intensive care unit transfer delay and hospital mortality: a multicenter investigation. J Hosp Med. 2016;11(11):757–62.PubMed Churpek MM, Wendlandt B, Zadravecz FJ, Adhikari R, Winslow C, Edelson DP. Association between intensive care unit transfer delay and hospital mortality: a multicenter investigation. J Hosp Med. 2016;11(11):757–62.PubMed
23.
go back to reference Kramer AA, Higgins TL, Zimmerman JE. Intensive care unit readmissions in U.S. hospitals: patient characteristics, risk factors, and outcomes. Crit Care Med. 2012;40(1):3–10.PubMed Kramer AA, Higgins TL, Zimmerman JE. Intensive care unit readmissions in U.S. hospitals: patient characteristics, risk factors, and outcomes. Crit Care Med. 2012;40(1):3–10.PubMed
24.
go back to reference Yang S, Wang Z, Liu Z, Wang J, Ma L. Association between time of discharge from ICU and hospital mortality: a systematic review and meta-analysis. Crit Care. 2016;20(1):390.PubMedPubMedCentral Yang S, Wang Z, Liu Z, Wang J, Ma L. Association between time of discharge from ICU and hospital mortality: a systematic review and meta-analysis. Crit Care. 2016;20(1):390.PubMedPubMedCentral
25.
go back to reference Laupland KB, Shahpori R, Kirkpatrick AW, Stelfox HT. Hospital mortality among adults admitted to and discharged from intensive care on weekends and evenings. J Crit Care. 2008;23(3):317–24.PubMed Laupland KB, Shahpori R, Kirkpatrick AW, Stelfox HT. Hospital mortality among adults admitted to and discharged from intensive care on weekends and evenings. J Crit Care. 2008;23(3):317–24.PubMed
26.
go back to reference Wong EG, Parker AM, Leung DG, Brigham EP, Arbaje AI. Association of severity of illness and intensive care unit readmission: a systematic review. Heart Lung. 2016;45(1):3–9 e2.PubMedPubMedCentral Wong EG, Parker AM, Leung DG, Brigham EP, Arbaje AI. Association of severity of illness and intensive care unit readmission: a systematic review. Heart Lung. 2016;45(1):3–9 e2.PubMedPubMedCentral
27.
go back to reference Rosenberg AL, Watts C. Patients readmitted to ICUs* : a systematic review of risk factors and outcomes. Chest. 2000;118(2):492–502.PubMed Rosenberg AL, Watts C. Patients readmitted to ICUs* : a systematic review of risk factors and outcomes. Chest. 2000;118(2):492–502.PubMed
28.
go back to reference Ponzoni CR, Correa TD, Filho RR, Serpa Neto A, Assuncao MSC, Pardini A, et al. Readmission to the intensive care unit: incidence, risk factors, resource use, and outcomes. A retrospective cohort study. Ann Am Thorac Soc. 2017;14(8):1312–9.PubMed Ponzoni CR, Correa TD, Filho RR, Serpa Neto A, Assuncao MSC, Pardini A, et al. Readmission to the intensive care unit: incidence, risk factors, resource use, and outcomes. A retrospective cohort study. Ann Am Thorac Soc. 2017;14(8):1312–9.PubMed
29.
go back to reference Keats AS. The ASA classification of physical status--a recapitulation. Anesthesiology. 1978;49(4):233–6.PubMed Keats AS. The ASA classification of physical status--a recapitulation. Anesthesiology. 1978;49(4):233–6.PubMed
30.
go back to reference Wong TH, Nguyen HV, Chiu MT, Chow KY, Ong ME, Lim GH, et al. The low fall as a surrogate marker of frailty predicts long-term mortality in older trauma patients. PLoS One. 2015;10(9):e0137127.PubMedPubMedCentral Wong TH, Nguyen HV, Chiu MT, Chow KY, Ong ME, Lim GH, et al. The low fall as a surrogate marker of frailty predicts long-term mortality in older trauma patients. PLoS One. 2015;10(9):e0137127.PubMedPubMedCentral
31.
go back to reference Marcin JP, Romano PS. Impact of between-hospital volume and within-hospital volume on mortality and readmission rates for trauma patients in California. Crit Care Med. 2004;32(7):1477–83.PubMed Marcin JP, Romano PS. Impact of between-hospital volume and within-hospital volume on mortality and readmission rates for trauma patients in California. Crit Care Med. 2004;32(7):1477–83.PubMed
32.
go back to reference Marx WH, Simon R, O'Neill P, Shapiro MJ, Cooper AC, Farrell LS, et al. The relationship between annual hospital volume of trauma patients and in-hospital mortality in New York state. J Trauma. 2011;71(2):339–45 discussion 45-6.PubMed Marx WH, Simon R, O'Neill P, Shapiro MJ, Cooper AC, Farrell LS, et al. The relationship between annual hospital volume of trauma patients and in-hospital mortality in New York state. J Trauma. 2011;71(2):339–45 discussion 45-6.PubMed
33.
go back to reference Nathens AB, Jurkovich GJ, Maier RV, Grossman DC, MacKenzie EJ, Moore M, et al. Relationship between trauma center volume and outcomes. JAMA. 2001;285(9):1164–71.PubMed Nathens AB, Jurkovich GJ, Maier RV, Grossman DC, MacKenzie EJ, Moore M, et al. Relationship between trauma center volume and outcomes. JAMA. 2001;285(9):1164–71.PubMed
34.
go back to reference Cooper A, Hannan EL, Bessey PQ, Farrell LS, Cayten CG, Mottley L. An examination of the volume-mortality relationship for New York State trauma centers. J Trauma. 2000;48(1):16–23 discussion −4.PubMed Cooper A, Hannan EL, Bessey PQ, Farrell LS, Cayten CG, Mottley L. An examination of the volume-mortality relationship for New York State trauma centers. J Trauma. 2000;48(1):16–23 discussion −4.PubMed
35.
go back to reference Demetriades D, Martin M, Salim A, Rhee P, Brown C, Chan L. The effect of trauma center designation and trauma volume on outcome in specific severe injuries. Ann Surg. 2005;242(4):512–7 discussion 7-9.PubMedPubMedCentral Demetriades D, Martin M, Salim A, Rhee P, Brown C, Chan L. The effect of trauma center designation and trauma volume on outcome in specific severe injuries. Ann Surg. 2005;242(4):512–7 discussion 7-9.PubMedPubMedCentral
36.
go back to reference Glance LG, Osler TM, Dick A, Mukamel D. The relation between trauma center outcome and volume in the National Trauma Databank. J Trauma. 2004;56(3):682–90.PubMed Glance LG, Osler TM, Dick A, Mukamel D. The relation between trauma center outcome and volume in the National Trauma Databank. J Trauma. 2004;56(3):682–90.PubMed
37.
go back to reference Bell TM, Boustany KC, Jenkins PC, Zarzaur BL. The relationship between trauma center volume and in-hospital outcomes. J Surg Res. 2015;196(2):350–7.PubMed Bell TM, Boustany KC, Jenkins PC, Zarzaur BL. The relationship between trauma center volume and in-hospital outcomes. J Surg Res. 2015;196(2):350–7.PubMed
38.
go back to reference Holena DN, Kaufman EJ, Delgado MK, Wiebe DJ, Carr BG, Christie JD, et al. A metric of our own: failure to rescue after trauma. J Trauma Acute Care Surg. 2017;83(4):698–704.PubMedPubMedCentral Holena DN, Kaufman EJ, Delgado MK, Wiebe DJ, Carr BG, Christie JD, et al. A metric of our own: failure to rescue after trauma. J Trauma Acute Care Surg. 2017;83(4):698–704.PubMedPubMedCentral
39.
go back to reference Moore L, Stelfox HT, Turgeon AF. Complication rates as a trauma care performance indicator: a systematic review. Crit Care. 2012;16(5):R195.PubMedPubMedCentral Moore L, Stelfox HT, Turgeon AF. Complication rates as a trauma care performance indicator: a systematic review. Crit Care. 2012;16(5):R195.PubMedPubMedCentral
40.
go back to reference Chung JJ, Earl-Royal EC, Delgado MK, Pascual JL, Reilly PM, Wiebe DJ, et al. Where we fail: location and timing of failure to Rescue in Trauma. Am Surg. 2017;83(3):250–6.PubMedPubMedCentral Chung JJ, Earl-Royal EC, Delgado MK, Pascual JL, Reilly PM, Wiebe DJ, et al. Where we fail: location and timing of failure to Rescue in Trauma. Am Surg. 2017;83(3):250–6.PubMedPubMedCentral
41.
go back to reference Sharoky CE, Martin ND, Smith BP, Pascual JL, Kaplan LJ, Reilly PM, et al. The location and timing of failure-to-rescue events across a statewide trauma system. J Surg Res. 2019;235:529–35.PubMed Sharoky CE, Martin ND, Smith BP, Pascual JL, Kaplan LJ, Reilly PM, et al. The location and timing of failure-to-rescue events across a statewide trauma system. J Surg Res. 2019;235:529–35.PubMed
42.
go back to reference Rauf R, von Matthey F, Croenlein M, Zyskowski M, van Griensven M, Biberthaler P, et al. Changes in the temporal distribution of in-hospital mortality in severely injured patients-an analysis of the TraumaRegister DGU. PLoS One. 2019;14(2):e0212095.PubMedPubMedCentral Rauf R, von Matthey F, Croenlein M, Zyskowski M, van Griensven M, Biberthaler P, et al. Changes in the temporal distribution of in-hospital mortality in severely injured patients-an analysis of the TraumaRegister DGU. PLoS One. 2019;14(2):e0212095.PubMedPubMedCentral
Metadata
Title
Mortality in severely injured patients: nearly one of five non-survivors have been already discharged alive from ICU
Authors
Uwe Hamsen
Niklas Drotleff
Rolf Lefering
Julius Gerstmeyer
Thomas Armin Schildhauer
Christian Waydhas
TraumaRegister DGU 
Publication date
01-12-2020
Publisher
BioMed Central
Keywords
Care
Living Will
Published in
BMC Anesthesiology / Issue 1/2020
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/s12871-020-01159-8

Other articles of this Issue 1/2020

BMC Anesthesiology 1/2020 Go to the issue