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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2020

Open Access 01-12-2020 | Migraine | Research article

Burden of migraine among Japanese patients: a cross-sectional National Health and Wellness Survey

Authors: Shoji Kikui, Yirong Chen, Hiroshi Todaka, Keiko Asao, Kenji Adachi, Takao Takeshima

Published in: The Journal of Headache and Pain | Issue 1/2020

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Abstract

Background

Limited studies have measured the burden of migraine in Japan. This study aimed at estimating the disease burden of migraine in Japan and identifying factors associated with the burden using the 2017 National Health and Wellness Survey.

Methods

Migraine patients were defined by ICHD-3 like criteria with ≥4 monthly headache days (MHDs), and non-migraine respondents were selected using 1:4 propensity score matching. Multivariate analyses were conducted to compare Health-related Quality of Life (HRQoL), work productivity and activity impairment (WPAI), healthcare resource utilization (HRU) and costs between the two groups, and to identify factors associated with these outcomes in migraine patients.

Results

In 30,001 respondents, 378 migraine patients were identified. Compared to matched controls (N = 1512), migraine patients had lower physical (45.17 vs. 49.89), mental (42.28 vs. 47.71) and role/social (37.91 vs. 44.19) component summary scores (p < 0.001). Migraine patients had higher absenteeism (6.4% vs. 2.2%), presenteeism (40.2% vs. 22.5%), total work productivity impairment (44.3% vs. 24.5%), total activity impairment (45.0% vs. 23.9%), indirect costs (1,492,520 JPY vs. 808,320 JPY) and more visits to healthcare providers in the past 6 months (7.23 vs. 3.96) (p < 0.001). More MHDs was associated with worse HRQoL, and higher HRU and indirect costs.

Conclusions

Japanese migraine patients experience an incremental burden. This demonstrates the unmet needs among Japanese migraine patients.
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Literature
1.
Agosti R (2018) Migraine burden of disease: from the Patient’s experience to a socio-economic view. Headache 58:17–32CrossRef
2.
3.
Deshpande PR, Rajan S, Sudeepthi BL, Abdul Nazir CP (2011) Patient-reported outcomes: a new era in clinical research. Perspect Clin Res 2:137–144CrossRef
4.
GBD 2016 Disease and Injury Incidence and Prevalence Collaborators (2017) Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 390:1211–1259CrossRef
5.
Stovner L, Hagen K, Jensen R, Katsarava Z, Lipton R, Scher A et al (2007) The global burden of headache: a documentation of headache prevalence and disability worldwide. Cephalalgia. 27:193–210CrossRef
6.
Vo P, Fang J, Bilitou A, Laflamme AK, Gupta S (2018) Patients’ perspective on the burden of migraine in Europe: a cross-sectional analysis of survey data in France, Germany, Italy, Spain, and the United Kingdom. J Headache Pain. 19:82CrossRef
7.
Hazard E, Munakata J, Bigal ME, Rupnow MFT, Lipton RB (2009) The burden of migraine in the United States: current and emerging perspectives on disease management and economic analysis. Value Health 12:55–64CrossRef
8.
Leonardi M, Raggi A (2019) A narrative review on the burden of migraine: when the burden is the impact on people’s life. J Headache Pain 20:41CrossRef
9.
Takeshima T, Wan Q, Zhang Y, Komori M, Stretton S, Rajan N et al (2019) Prevalence, burden, and clinical management of migraine in China, Japan, and South Korea: a comprehensive review of the literature. J Headache Pain. 20:111CrossRef
10.
Ueda K, Ye W, Lombard L, Kuga A, Kim Y, Cotton S et al (2019) Real-world treatment patterns and patient-reported outcomes in episodic and chronic migraine in Japan: analysis of data from the Adelphi migraine disease specific programme. J Headache Pain 20:68CrossRef
11.
Sakai F, Igarashi H (1997) Prevalence of migraine in Japan: a nationwide survey. Cephalalgia. 17:15–22CrossRef
12.
Takeshima T, Ishizaki K, Fukuhara Y, Ijiri T, Kusumi M, Wakutani Y et al (2004) Population-based door-to-door survey of migraine in Japan: the Daisen study. Headache. 44:8–19CrossRef
13.
Kitamura T, Makanaka S, Sakai F, Iwata M, Hirata K, Takeshima T (2003) Current status of clinical practice and patients’ satisfaction survey of migraine. J Japanese Soc Headache 30:53–55
14.
Sakai F (2002) Epidemiology of headache and medical economics. Adv Neurological Res 46:343–349
15.
16.
17.
Bolge SC, Doan JF, Kannan H, Baran RW (2009) Association of insomnia with quality of life, work productivity, and activity impairment. Qual Life Res 18:415–422CrossRef
18.
DiBonaventura MD, Wagner J-S, Yuan Y, L’Italien G, Langley P, Ray KW (2010) Humanistic and economic impacts of hepatitis C infection in the United States. J Med Econ 13:709–718CrossRef
19.
Goadsby PJ, Reuter U, Hallström Y, Broessner G, Bonner JH, Zhang F et al (2017) A controlled trial of Erenumab for episodic migraine. N Engl J Med 377:2123–2132CrossRef
20.
Dodick DW, Ashina M, Brandes JL, Kudrow D, Lanteri-Minet M, Osipova V et al (2018) ARISE: a phase 3 randomized trial of erenumab for episodic migraine. Cephalalgia. 38:1026–1037CrossRef
21.
Sakai F, Takeshima T, Tatsuoka Y, Hirata K, Lenz R, Wang Y et al (2019) A randomized phase 2 study of Erenumab for the prevention of episodic migraine in Japanese adults. Headache. 59:1731–1742CrossRef
22.
Charlson ME, Charlson RE, Peterson JC, Marinopoulos SS, Briggs WM, Hollenberg JP (2008) The Charlson comorbidity index is adapted to predict costs of chronic disease in primary care patients. J Clin Epidemiol 61:1234–1240CrossRef
23.
Quan H, Li B, Couris CM, Fushimi K, Graham P, Hider P et al (2011) Updating and validating the Charlson comorbidity index and score for risk adjustment in hospital discharge abstracts using data from 6 countries. Am J Epidemiol 173:676–682CrossRef
24.
25.
Fumihiko S, Yasuo F, Makoto I, Jun’ichi H, Hisaka I, Toshihiko S et al (2004) Evaluation of Reliability of the Japanese Version “Headache Impact Test (HIT-6)” | Article Information. J-GLOBAL. 臨床医薬 20:1045–1054
26.
Yang M, Rendas-Baum R, Varon SF, Kosinski M (2011) Validation of the headache impact test (HIT-6™) across episodic and chronic migraine. Cephalalgia. 31:357–367CrossRef
27.
Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K (1998) Translation, adaptation, and validation of the SF-36 health survey for use in Japan. J Clin Epidemiol 51:1037–1044CrossRef
28.
Suzukamo Y, Fukuhara S, Green J, Kosinski M, Gandek B, Ware JE (2011) Validation testing of a three-component model of short Form-36 scores. J Clin Epidemiol 64:301–308CrossRef
29.
Fukuhara S, Ware JE, Kosinski M, Wada S, Gandek B (1998) Psychometric and clinical tests of validity of the Japanese SF-36 health survey. J Clin Epidemiol 51:1045–1053CrossRef
30.
Liu GG, da Costa DBM, Yuan Y, Wagner J-S, L’Italien GJ, Langley P et al (2012) The burden of illness for patients with viral hepatitis C: evidence from a National Survey in Japan. Value Health 15:S65–S71CrossRef
31.
Reilly MC, Gooch KL, Wong RL, Kupper H, van der Heijde D (2010) Validity, reliability and responsiveness of the work productivity and activity impairment questionnaire in ankylosing spondylitis. Rheumatology (Oxford) 49:812–819CrossRef
32.
33.
34.
IBM Corp (2013) IBM SPSS Statistics for Windows, Version 22.0. IBM Corp, Armonk
35.
R Core Team. R: A language and environment for statistical computing. 2018
36.
Maruish ME (2011) User’s Manual for the SF-36v2 Health Survey. 3rd edition. Quality Metric Incorporated
37.
Buse DC, Rupnow MFT, Lipton RB (2009) Assessing and managing all aspects of migraine: migraine attacks, migraine-related functional impairment, common comorbidities, and quality of life. Mayo Clin Proc 84:422–435CrossRef
38.
Silberstein SD, Lee L, Gandhi K, Fitzgerald T, Bell J, Cohen JM (2018) Health care resource utilization and migraine disability along the migraine continuum among patients treated for migraine. Headache. 58:1579–1592CrossRef
39.
Bonafede M, Sapra S, Shah N, Tepper S, Cappell K, Desai P (2018) Direct and indirect healthcare resource utilization and costs among migraine patients in the United States. Headache. 58:700–714CrossRef
40.
41.
Stovner LJ, Zwart J-A, Hagen K, Terwindt GM, Pascual J (2006) Epidemiology of headache in Europe. Eur J Neurol 13:333–345CrossRef
42.
Stovner LJ, Andree C (2010) Prevalence of headache in Europe: a review for the Eurolight project. J Headache Pain. 11:289–299CrossRef
43.
Burch R, Rizzoli P, Loder E (2018) The prevalence and impact of migraine and severe headache in the United States: figures and trends from government health studies. Headache. 58:496–505CrossRef
44.
Meyers JL, Davis KL, Lenz RA, Sakai F, Xue F (2019) Treatment patterns and characteristics of patients with migraine in Japan: a retrospective analysis of health insurance claims data. Cephalalgia. 39:1518–1534CrossRef
45.
López Martínez M d V, Pareja Román J, Jiménez Hernández MD, Maestu Unturbe C, Ramírez-Castillejo M del C (2020) Chronic Migraine with Medication Overuse: Clinical Pattern and Evolution from a Retrospective Cohort in Seville, Spain. SN Compr Clin Med. https://​doi.​org/​10.​1007/​s42399-020-00424-8
46.
Metadata
Title
Burden of migraine among Japanese patients: a cross-sectional National Health and Wellness Survey
Authors
Shoji Kikui
Yirong Chen
Hiroshi Todaka
Keiko Asao
Kenji Adachi
Takao Takeshima
Publication date
01-12-2020
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2020
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-020-01180-9

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