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The Journal of Headache and Pain
Published in: The Journal of Headache and Pain 1/2015

Open Access 01-12-2016 | Research article

Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis

Authors: Gianluca Coppola, Antonio Di Renzo, Emanuele Tinelli, Chiara Lepre, Cherubino Di Lorenzo, Giorgio Di Lorenzo, Marco Scapeccia, Vincenzo Parisi, Mariano Serrao, Claudio Colonnese, Jean Schoenen, Francesco Pierelli

Published in: The Journal of Headache and Pain | Issue 1/2015

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Abstract

Background

Resting state magnetic resonance imaging allows studying functionally interconnected brain networks. Here we were aimed to verify functional connectivity between brain networks at rest and its relationship with thalamic microstructure in migraine without aura (MO) patients between attacks.

Methods

Eighteen patients with untreated MO underwent 3 T MRI scans and were compared to a group of 19 healthy volunteers (HV). We used MRI to collect resting state data among two selected resting state networks, identified using group independent component (IC) analysis. Fractional anisotropy (FA) and mean diffusivity (MD) values of bilateral thalami were retrieved from a previous diffusion tensor imaging study on the same subjects and correlated with resting state ICs Z-scores.

Results

In comparison to HV, in MO we found significant reduced functional connectivity between the default mode network and the visuo-spatial system. Both HV and migraine patients selected ICs Z-scores correlated negatively with FA values of the thalamus bilaterally.

Conclusions

The present results are the first evidence supporting the hypothesis that an abnormal resting within networks connectivity associated with significant differences in baseline thalamic microstructure could contribute to interictal migraine pathophysiology.
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Metadata
Title
Thalamo-cortical network activity between migraine attacks: Insights from MRI-based microstructural and functional resting-state network correlation analysis
Authors
Gianluca Coppola
Antonio Di Renzo
Emanuele Tinelli
Chiara Lepre
Cherubino Di Lorenzo
Giorgio Di Lorenzo
Marco Scapeccia
Vincenzo Parisi
Mariano Serrao
Claudio Colonnese
Jean Schoenen
Francesco Pierelli
Publication date
01-12-2016
Publisher
Springer Milan
Published in
The Journal of Headache and Pain / Issue 1/2015
Print ISSN: 1129-2369
Electronic ISSN: 1129-2377
DOI
https://doi.org/10.1186/s10194-016-0693-y

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