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Respiratory Research
Published in: Respiratory Research 4/2001

Open Access 01-08-2001 | Review

Viruses, dendritic cells and the lung

Authors: R Stokes Peebles Jr, Barney S Graham, MD, PhD

Published in: Respiratory Research | Issue 4/2001

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Abstract

The interaction between viruses and dendritic cells (DCs) is varied and complex. DCs are key elements in the development of a host response to pathogens such as viruses, but viruses have developed survival tactics to either evade or diminish the immune system that functions to kill and eliminate these micro-organisms. In the present review we summarize current concepts regarding the function of DCs in the immune system, our understanding of how viruses alter DC function to attenuate both the virus-specific and global immune response, and how we may be able to exploit DC function to prevent or treat viral infections.
Literature
1.
Banchereau J, Briere F, Caux C, Davoust J, Lebecque S, Liu YJ, Pulendran B, Palucka K: Immunobiology of dendritic cells. Annu Rev Immunol. 2000, 18: 767-811. 10.1146/annurev.immunol.18.1.767.PubMedCrossRef
2.
Drake DR, Moser JM, Hadley A, Altman JD, Maliszewski C, Butz E, Lukacher AE: Polyomavirus-infected dendritic cells induce antiviral CD8(+) T lymphocytes. J Virol. 2000, 74: 4093-4101. 10.1128/JVI.74.9.4093-4101.2000.PubMedPubMedCentralCrossRef
3.
Drake DR, Shawver ML, Hadley A, Butz E, Maliszewski C, Lukacher AE: Induction of polyomavirus-specific CD8(+) T lymphocytes by distinct dendritic cell subpopulations. J Virol. 2001, 75: 544-547. 10.1128/JVI.75.1.544-547.2001.PubMedPubMedCentralCrossRef
4.
Ridge JP, Di Rosa F, Matzinger P: A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell. Nature. 1998, 393: 474-478. 10.1038/30989.PubMedCrossRef
5.
Borrow P, Evans CF, Oldstone MB: Virus-induced immunosup-pression: immune system-mediated destruction of virus-infected dendritic cells results in generalized immune suppression. J Virol. 1995, 69: 1059-1070.PubMedPubMedCentral
6.
Larsson M, Messmer D, Somersan S, Fonteneau JF, Donahoe SM, Lee M, Dunbar PR, Cerundolo V, Julkunen I, Nixon DF, Bhardwaj N: Requirement of mature dendritic cells for efficient activation of influenza A-specific memory CD8+ T cells. J Immunol. 2000, 165: 1182-1190.PubMedCrossRef
7.
King C, Mueller HR, Malo CM, Murali-Krishna K, Ahmed R, King E, Sarvetnick N: Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+T-cell responses. Nat Med. 2001, 7: 206-214. 10.1038/84659.PubMedCrossRef
8.
Aung S, Tang YW, Graham BS: Interleukin-4 diminishes CD8(+) respiratory syncytial virus-specific cytotoxic T-lymphocyte activity in vivo. J Virol. 1999, 73: 8944-8949.PubMedPubMedCentral
9.
Aung S, Graham BS: IL-4 diminishes perforin-mediated and increases Fas ligand-mediated cytotoxicity in vivo. J Immunol. 2000, 164: 3487-3493.PubMedCrossRef
10.
Banchereau J, Steinman RM: Dendritic cells and the control of immunity. Nature. 1998, 392: 245-252. 10.1038/32588.PubMedCrossRef
11.
Cella M, Salio M, Sakakibara Y, Langen H, Julkunen I, Lanzavecchia A: Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J Exp Med. 1999, 189: 821-829. 10.1084/jem.189.5.821.PubMedPubMedCentralCrossRef
12.
Schnorr JJ, Xanthakos S, Keikavoussi P, Kampgen E, ter Meulen V, Schneider-Schaulies S: Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression. Proc Natl Acad Sci USA. 1997, 94: 5326-5331. 10.1073/pnas.94.10.5326.PubMedPubMedCentralCrossRef
13.
Winzler C, Rovere P, Rescigno M, Granucci F, Penna G, Adorini L, Zimmermann VS, Davoust J, Ricciardi-Castagnoli P: Maturation stages of mouse dendritic cells in growth factor-dependent long-term cultures. J Exp Med. 1997, 185: 317-328. 10.1084/jem.185.2.317.PubMedPubMedCentralCrossRef
14.
Engelmayer J, Larsson M, Subklewe M, Chahroudi A, Cox WI, Steinman RM, Bhardwaj N: Vaccinia virus inhibits the maturation of human dendritic cells: a novel mechanism of immune evasion. J Immunol. 1999, 163: 6762-6768.PubMed
15.
Moss B: Poxviridae: the viruses and their replication. In: Fields Virology. Edited by Fields BN, Knipe DM, Howley PM. Philadelphia: Lippincott-Raven. 1996, 2637-2672.
16.
Luft T, Pang KC, Thomas E, Hertzog P, Hart DN, Trapani J, Cebon J: Type I IFNs enhance the terminal differentiation of dendritic cells. J Immunol. 1998, 161: 1947-1953.PubMed
17.
Reddy A, Sapp M, Feldman M, Subklewe M, Bhardwaj N: A monocyte conditioned medium is more effective than defined cytokines in mediating the terminal maturation of human dendritic cells. Blood. 1997, 90: 3640-3646.PubMed
18.
Sallusto F, Cella M, Danieli C, Lanzavecchia A: Dendritic cells use macropinocytosis and the mannose receptor to concentrate macromolecules in the major histocompatibility complex class II compartment: downregulation by cytokines and bacterial products. J Exp Med. 1995, 182: 389-400.PubMedCrossRef
19.
Karp CL, Wysocka M, Wahl LM, Ahearn JM, Cuomo PJ, Sherry B, Trinchieri G, Griffin DE: Mechanism of suppression of cell-mediated immunity by measles virus. Science. 1996, 273: 228-231.PubMedCrossRef
20.
Marie JC, Kehren J, Trescol-Biemont M, Evlashev A, Valentin H, Walzer T, Tedone R, Loveland B, Nicolas J, Rabourdin-Combe C, Horvat B: Mechanism of measles virus-induced suppression of inflammatory immune responses. Immunity. 2001, 14: 69-79.PubMedCrossRef
21.
Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G: Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med. 1996, 184: 747-752.PubMedCrossRef
22.
Koch F, Stanzl U, Jennewein P, Janke K, Heufler C, Kampgen E, Romani N, Schuler G: High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med. 1996, 184: 741-746.PubMedCrossRef
23.
Servet-Delprat C, Vidalain PO, Bausinger H, Manie S, Le Deist F, Azocar O, Hanau D, Fischer A, Rabourdin-Combe C: Measles virus induces abnormal differentiation of CD40 ligand-activated human dendritic cells. J Immunol. 2000, 164: 1753-1760.PubMedCrossRef
24.
Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature. 1996, 383: 787-793. 10.1038/383787a0.PubMedCrossRef
25.
Vidalain PO, Azocar O, Lamouille B, Astier A, Rabourdin-Combe C, Servet-Delprat C: Measles virus induces functional TRAIL production by human dendritic cells. J Virol. 2000, 74: 556-559.PubMedPubMedCentralCrossRef
26.
Jeremias I, Herr I, Boehler T, Debatin KM: TRAIL/Apo-2-ligand-induced apoptosis in human T cells. Eur J Immunol. 1998, 28: 143-152. 10.1002/(SICI)1521-4141(199801)28:01<143::AID-IMMU143>3.3.CO;2-V.PubMedCrossRef
27.
Kruse M, Rosorius O, Kratzer F, Stelz G, Kuhnt C, Schuler G, Hauber J, Steinkasserer A: Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity. J Virol. 2000, 74: 7127-7136. 10.1128/JVI.74.15.7127-7136.2000.PubMedPubMedCentralCrossRef
28.
Hill A, Jugovic P, York I, Russ G, Bennink J, Yewdell J, Ploegh H, Johnson D: Herpes simplex virus turns off the TAP to evade host immunity. Nature. 1995, 375: 411-415. 10.1038/375411a0.PubMedCrossRef
29.
Fruh K, Ahn K, Djaballah H, Sempe P, van Endert PM, Tampe R, Peterson PA, Yang Y: A viral inhibitor of peptide transporters for antigen presentation. Nature. 1995, 375: 415-418. 10.1038/375415a0.PubMedCrossRef
30.
Kruse M, Rosorius O, Kratzer F, Bevec D, Kuhnt C, Steinkasserer A, Schuler G, Hauber J: Inhibition of CD83 cell surface expression during dendritic cell maturation by interference with nuclear export of CD83 mRNA. J Exp Med. 2000, 191: 1581-1590. 10.1084/jem.191.9.1581.PubMedPubMedCentralCrossRef
31.
Flano E, Husain SM, Sample JT, Woodland DL, Blackman MA: Latent murine gamma-herpesvirus infection is established in activated B cells, dendritic cells, and macrophages. J Immunol. 2000, 165: 1074-1081.PubMedCrossRef
32.
Wu SJ, Grouard-Vogel G, Sun W, Mascola JR, Brachtel E, Put-vatana R, Louder MK, Filgueira L, Marovich MA, Wong HK, Blauvelt A, Murphy GS, Robb ML, Innes BL, Birx DL, Hayes CG, Frankel SS: Human skin Langerhans cells are targets of dengue virus infection. Nat Med. 2000, 6: 816-820. 10.1038/77553.PubMedCrossRef
33.
Jahn G, Stenglein S, Riegler S, Einsele H, Sinzger C: Human cytomegalovirus infection of immature dendritic cells and macrophages. Intervirology. 1999, 42: 365-372. 10.1159/000053973.PubMedCrossRef
34.
MacDonald GH, Johnston RE: Role of dendritic cell targeting in Venezuelan equine encephalitis virus pathogenesis. J Virol. 2000, 74: 914-922. 10.1128/JVI.74.2.914-922.2000.PubMedPubMedCentralCrossRef
35.
Tortorella D, Gewurz B, Schust D, Furman M, Ploegh H: Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. Immunol Invest. 2000, 29: 97-100.PubMedCrossRef
36.
Hahn G, Jores R, Mocarski ES: Cytomegalovirus remains latent in a common precursor of dendritic cells and myeloid cells. Proc Natl Acad Sci USA. 1998, 95: 3937-3942. 10.1073/pnas.95.7.3937.PubMedPubMedCentralCrossRef
37.
Heath SL, Tew SG, Tew JG, Szakal AK, Burton GF: Follicular dendritic cells and human immunodeficiency virus infectivity. Nature. 1995, 377: 740-744. 10.1038/377740a0.PubMedCrossRef
38.
Latouche JB, Sadelain M: Induction of human cytotoxic T lymphocytes by artificial antigen-presenting cells. Nat Biotechnol. 2000, 18: 405-409. 10.1038/74455.PubMedCrossRef
Metadata
Title
Viruses, dendritic cells and the lung
Authors
R Stokes Peebles Jr
Barney S Graham, MD, PhD
Publication date
01-08-2001
Publisher
BioMed Central
Published in
Respiratory Research / Issue 4/2001
Electronic ISSN: 1465-993X
DOI
https://doi.org/10.1186/rr63

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Keynote webinar | Spotlight on medication adherence

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WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

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