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Critical Care
Published in: Critical Care 1/2011

Open Access 01-02-2011 | Poster presentation

Danger signal uric acid is involved in ventilator-induced lung injury pathogenesis

Authors: M Kuipers, H Aslami, T Van der Poll, M Schultz, C Wieland

Published in: Critical Care | Special Issue 1/2011

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Excerpt

Endogenous molecules released during tissue injury can trigger an innate immune response and are termed damage-associated molecular patterns (DAMPs). Uric acid is considered an important DAMP and causes acute lung inflammation when administered locally. The exact role of the innate immune response in ventilator-induced lung injury (VILI) is not yet completely understood. We hypothesized that uric acid is released during VILI and that reduction of uric acid levels attenuates lung injury induced by short-term mechanical ventilation (MV). …
Metadata
Title
Danger signal uric acid is involved in ventilator-induced lung injury pathogenesis
Authors
M Kuipers
H Aslami
T Van der Poll
M Schultz
C Wieland
Publication date
01-02-2011
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 1/2011
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc9612

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