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01-10-2008 | Viewpoint

Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study

Authors: Claudio Ronco, Dinna Cruz, Helen Oudemans van Straaten, Patrick Honore, Andrew House, Du Bin, Noel Gibney

Published in: Critical Care | Issue 5/2008

Abstract

The optimal dialysis dose for acute kidney injury is a matter of great controversy. Clinical trials, predominantly single-center studies, have shown conflicting results. The Acute Renal Failure Trial Network (ATN) Study was designed to compare clinical outcomes between patients allocated to an intensive dose versus a less-intensive dose of renal replacement therapy. Recently, the results of this large randomized controlled multicenter study were published. The present article will discuss certain aspects of this trial: the overall design, the baseline patient characteristics, and comparison of the results with earlier studies. Finally, the article will address the implications of the ATN Study results for clinical practice.

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Title: Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study
Authors: Claudio Ronco
Dinna Cruz
Helen Oudemans van Straaten
Patrick Honore
Andrew House
Du Bin
Noel Gibney
Publication date: 01-10-2008
Publisher: BioMed Central
Published in: Critical Care / Issue 5/2008
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc7016

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Dialysis dose in acute kidney injury: no time for therapeutic nihilism – a critical appraisal of the Acute Renal Failure Trial Network study

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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